| UniProt ID | PLAL1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UM63 | |
| Protein Name | Zinc finger protein PLAGL1 | |
| Gene Name | PLAGL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 463 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.. | |
| Protein Sequence | MATFPCQLCGKTFLTLEKFTIHNYSHSRERPYKCVQPDCGKAFVSRYKLMRHMATHSPQKSHQCAHCEKTFNRKDHLKNHLQTHDPNKMAFGCEECGKKYNTMLGYKRHLALHAASSGDLTCGVCALELGSTEVLLDHLKAHAEEKPPSGTKEKKHQCDHCERCFYTRKDVRRHLVVHTGCKDFLCQFCAQRFGRKDHLTRHTKKTHSQELMKESLQTGDLLSTFHTISPSFQLKAAALPPFPLGASAQNGLASSLPAEVHSLTLSPPEQAAQPMQPLPESLASLHPSVSPGSPPPPLPNHKYNTTSTSYSPLASLPLKADTKGFCNISLFEDLPLQEPQSPQKLNPGFDLAKGNAGKVNLPKELPADAVNLTIPASLDLSPLLGFWQLPPPATQNTFGNSTLALGPGESLPHRLSCLGQQQQEPPLAMGTVSLGQLPLPPIPHVFSAGTGSAILPHFHHAFR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 25 | Phosphorylation | KFTIHNYSHSRERPY EEEECCCCCCCCCCC | 21.94 | 20068231 | |
| 27 | Phosphorylation | TIHNYSHSRERPYKC EECCCCCCCCCCCEE | 29.87 | 20068231 | |
| 102 | Phosphorylation | ECGKKYNTMLGYKRH HHHHHHHHHHHHHHH | 15.64 | 25101063 | |
| 106 | Phosphorylation | KYNTMLGYKRHLALH HHHHHHHHHHHHHHH | 10.82 | 25101063 | |
| 107 | Sumoylation | YNTMLGYKRHLALHA HHHHHHHHHHHHHHH | 31.38 | - | |
| 227 | Phosphorylation | DLLSTFHTISPSFQL CHHHHCEECCHHHCH | 20.96 | 29978859 | |
| 229 | Phosphorylation | LSTFHTISPSFQLKA HHHCEECCHHHCHHH | 18.69 | 29978859 | |
| 231 | Phosphorylation | TFHTISPSFQLKAAA HCEECCHHHCHHHHC | 20.87 | 29978859 | |
| 303 | Phosphorylation | PPLPNHKYNTTSTSY CCCCCCCCCCCCCCC | 15.36 | - | |
| 305 | Phosphorylation | LPNHKYNTTSTSYSP CCCCCCCCCCCCCCC | 21.02 | 28348404 | |
| 306 | Phosphorylation | PNHKYNTTSTSYSPL CCCCCCCCCCCCCCC | 26.77 | 28348404 | |
| 307 | Phosphorylation | NHKYNTTSTSYSPLA CCCCCCCCCCCCCCC | 17.20 | 28348404 | |
| 308 | Phosphorylation | HKYNTTSTSYSPLAS CCCCCCCCCCCCCCC | 29.59 | 28348404 | |
| 309 | Phosphorylation | KYNTTSTSYSPLASL CCCCCCCCCCCCCCC | 24.31 | 28348404 | |
| 310 | Phosphorylation | YNTTSTSYSPLASLP CCCCCCCCCCCCCCC | 17.88 | - | |
| 311 | Phosphorylation | NTTSTSYSPLASLPL CCCCCCCCCCCCCCC | 17.13 | 28348404 | |
| 319 | Ubiquitination | PLASLPLKADTKGFC CCCCCCCCCCCCCCC | 42.13 | - | |
| 341 | Phosphorylation | LPLQEPQSPQKLNPG CCCCCCCCCCCCCCC | 39.76 | 28450419 | |
| 353 | Ubiquitination | NPGFDLAKGNAGKVN CCCCCCCCCCCCCCC | 61.05 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PLAL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PLAL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PLAL1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| P53_HUMAN | TP53 | physical | 11360197 | |
| DAXX_HUMAN | DAXX | physical | 20097304 | |
| EP300_HUMAN | EP300 | physical | 16809786 | |
| CBP_HUMAN | CREBBP | physical | 16809786 | |
| HDAC1_HUMAN | HDAC1 | physical | 18644983 | |
| P73_HUMAN | TP73 | physical | 18663001 | |
| KAT2B_HUMAN | KAT2B | physical | 18663001 | |
| SUMO1_HUMAN | SUMO1 | physical | 22227369 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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