TSH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSH2_HUMAN
• UniProt AC: Q9NRE2
• Protein Name: Teashirt homolog 2
• Gene Name: TSHZ2
• Organism: Homo sapiens (Human).
• Sequence Length: 1034
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential)..
• Protein Sequence: MPRRKQQAPKRAAGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQSLSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSVLNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHALSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEISRVSSAQRSPETIAAEEDTDSKFKCKLCCRTFVSKHAVKLHLSKTHSKSPEHHSQFVTDVDEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Sumoylation	LKEEEEIKEEEEEED HHHHHHHHHHHHHHH	63.45	-
65	Phosphorylation	PEQKGCFSYQNSPGS CCCCCCCCCCCCCCC	29.86	29449344
66	Phosphorylation	EQKGCFSYQNSPGSH CCCCCCCCCCCCCCC	7.46	21712546
69	Phosphorylation	GCFSYQNSPGSHLSN CCCCCCCCCCCCCCC	18.34	28387310
72	Phosphorylation	SYQNSPGSHLSNQDA CCCCCCCCCCCCCCH	25.33	21712546
75	Phosphorylation	NSPGSHLSNQDAENE CCCCCCCCCCCHHCC	27.33	29449344
83	Phosphorylation	NQDAENESLLSDASD CCCHHCCHHHCCCHH	46.31	29449344
188	Sumoylation	LPSRSVSKPSLFSSV CCCCCCCCCHHHHHH	36.15	28112733
198	Phosphorylation	LFSSVQLYRQSSKMC HHHHHHHHHHHCCCC	6.90	29449344
210	Phosphorylation	KMCGTVFTGASRFRC CCCCCEECCCCCCEE	27.74	26126808
213	Phosphorylation	GTVFTGASRFRCRQC CCEECCCCCCEECCC	33.04	26126808
254	Phosphorylation	KDKLRPTSYSKPRKR CCCCCCCCCCCCCHH	30.05	29083192
255	Phosphorylation	DKLRPTSYSKPRKRA CCCCCCCCCCCCHHH	24.16	29083192
256	Phosphorylation	KLRPTSYSKPRKRAF CCCCCCCCCCCHHHC	35.63	29083192
300	Phosphorylation	HMIKTKHYQKVPLKE HEECCCCCCCCCCCC	16.16	-
302	Ubiquitination	IKTKHYQKVPLKEPV ECCCCCCCCCCCCCC	38.36	-
306	Sumoylation	HYQKVPLKEPVPTIS CCCCCCCCCCCCCCC	54.63	28112733
315	Sumoylation	PVPTISSKMVTPAKK CCCCCCCCCCCCCHH	30.51	28112733
329	Phosphorylation	KRVFDVNRPCSPDST HCEECCCCCCCCCCC	33.19	32142685
332	Phosphorylation	FDVNRPCSPDSTTGS ECCCCCCCCCCCCCC	34.13	22167270
335	Phosphorylation	NRPCSPDSTTGSFAD CCCCCCCCCCCCCHH	31.11	29632367
336	Phosphorylation	RPCSPDSTTGSFADS CCCCCCCCCCCCHHH	42.42	26657352
337	Phosphorylation	PCSPDSTTGSFADSF CCCCCCCCCCCHHHC	34.48	27732954
339	Phosphorylation	SPDSTTGSFADSFSS CCCCCCCCCHHHCCC	18.37	27732954
343	Phosphorylation	TTGSFADSFSSQKNA CCCCCHHHCCCCCCC	24.49	27732954
345	Phosphorylation	GSFADSFSSQKNANL CCCHHHCCCCCCCEE	35.49	27732954
346	Phosphorylation	SFADSFSSQKNANLQ CCHHHCCCCCCCEEE	43.07	27732954
355	Phosphorylation	KNANLQLSSNNRYGY CCCEEEECCCCCCCC	20.33	21712546
356	Phosphorylation	NANLQLSSNNRYGYQ CCEEEECCCCCCCCC	46.87	28555341
417	Sumoylation	SSASKKGKQLVLDPL CCCCCCCCEEEECHH	49.71	28112733
431	Phosphorylation	LAVEKMQSLSEAPNS HHHHHHHHHHCCCCC	30.29	28165663
433	Phosphorylation	VEKMQSLSEAPNSDS HHHHHHHHCCCCCCC	36.64	28165663
440	Phosphorylation	SEAPNSDSLAPKPSS HCCCCCCCCCCCCCC	26.67	28961369
446	Phosphorylation	DSLAPKPSSNSASDC CCCCCCCCCCCHHHC	48.56	30631047
447	Phosphorylation	SLAPKPSSNSASDCT CCCCCCCCCCHHHCC	43.24	30631047
449	Phosphorylation	APKPSSNSASDCTAS CCCCCCCCHHHCCCC	30.97	30631047
451	Phosphorylation	KPSSNSASDCTASTT CCCCCCHHHCCCCHH	32.79	30631047
454	Phosphorylation	SNSASDCTASTTELK CCCHHHCCCCHHHHH	28.74	28165663
456	Phosphorylation	SASDCTASTTELKKE CHHHCCCCHHHHHHH	20.08	28165663
457	Phosphorylation	ASDCTASTTELKKES HHHCCCCHHHHHHHH	23.09	28165663
458	Phosphorylation	SDCTASTTELKKESK HHCCCCHHHHHHHHH	36.50	28165663
461	Sumoylation	TASTTELKKESKKER CCCHHHHHHHHHCCC	48.54	-
461	Sumoylation	TASTTELKKESKKER CCCHHHHHHHHHCCC	48.54	28112733
480	Sumoylation	SKDEKVVKSEDYEDP CCCCCCCCCCCCCCC	51.63	-
480	Sumoylation	SKDEKVVKSEDYEDP CCCCCCCCCCCCCCC	51.63	28112733
497	Sumoylation	KPLDPTIKYQYLREE CCCCCCHHHEEECHH	28.87	28112733
519	Phosphorylation	GGGDILKSLENTVTT CCHHHHHHHHHHHHH	37.15	28555341
601	Sumoylation	LAPYTQVKKESEDKD CCCCCCCCCCCCCHH	40.79	-
601	Sumoylation	LAPYTQVKKESEDKD CCCCCCCCCCCCCHH	40.79	28112733
618	Phosphorylation	VKECGKESPHEEASS HHHHCCCCCCHHHHC	34.73	29449344
624	Phosphorylation	ESPHEEASSFSHSEG CCCCHHHHCCCCCCC	34.88	29449344
625	Phosphorylation	SPHEEASSFSHSEGD CCCHHHHCCCCCCCC	37.50	29449344
637	Phosphorylation	EGDSFRKSETPPEAK CCCCCCCCCCCCCHH	42.31	26657352
639	Phosphorylation	DSFRKSETPPEAKKT CCCCCCCCCCCHHCC	51.76	29396449
644	Acetylation	SETPPEAKKTELGPL CCCCCCHHCCCCCCH	59.57	18586655
645	Acetylation	ETPPEAKKTELGPLK CCCCCHHCCCCCCHH	55.04	18586661
652	Sumoylation	KTELGPLKEEEKLMK CCCCCCHHHHHHHHH	67.24	28112733
710	Phosphorylation	NNHLGKATEPLRSPS HHCCCCCCCCCCCCC	41.44	24719451
715	Phosphorylation	KATEPLRSPSCSSPS CCCCCCCCCCCCCCC	28.93	29214152
717	Phosphorylation	TEPLRSPSCSSPSSS CCCCCCCCCCCCCCC	28.07	29214152
719	Phosphorylation	PLRSPSCSSPSSSTI CCCCCCCCCCCCCCC	50.01	29214152
720	Phosphorylation	LRSPSCSSPSSSTIS CCCCCCCCCCCCCCH	32.88	29214152
722	Phosphorylation	SPSCSSPSSSTISMF CCCCCCCCCCCCHHH	38.58	29449344
723	Phosphorylation	PSCSSPSSSTISMFH CCCCCCCCCCCHHHC	34.58	29449344
724	Phosphorylation	SCSSPSSSTISMFHK CCCCCCCCCCHHHCC	33.81	29449344
732	Phosphorylation	TISMFHKSNLNVMDK CCHHHCCCCCCCCCC	37.67	28509920
743	Phosphorylation	VMDKPVLSPASTRSA CCCCCCCCCCCCCCC	20.75	29214152
746	Phosphorylation	KPVLSPASTRSASVS CCCCCCCCCCCCHHC	27.95	21712546
747	Phosphorylation	PVLSPASTRSASVSR CCCCCCCCCCCHHCH	30.65	27251275
770	Phosphorylation	QPIDLTKSKSKKAES CCCCCCCCCCCCCHH	36.61	21712546
777	Phosphorylation	SKSKKAESSQAQSCM CCCCCCHHHHHHHHC	32.39	29116813
778	Phosphorylation	KSKKAESSQAQSCMS CCCCCHHHHHHHHCC	22.50	29116813
782	Phosphorylation	AESSQAQSCMSPPQK CHHHHHHHHCCCCCH	18.14	29116813
785	Phosphorylation	SQAQSCMSPPQKHAL HHHHHHCCCCCHHHH	37.44	29116813
800	Sumoylation	SDIADMVKVLPKATT HHHHHHHHHCCCCCC	31.27	28112733
800	Sumoylation	SDIADMVKVLPKATT HHHHHHHHHCCCCCC	31.27	-
820	Sumoylation	SSRVPPMKLEMDVRR CCCCCCEEEEEEHHH	47.25	28112733
820	Sumoylation	SSRVPPMKLEMDVRR CCCCCCEEEEEEHHH	47.25	-
836	Phosphorylation	EDVSSEVSTLHKRKG HHCCHHHHHHHHHCC	22.62	28555341
837	Phosphorylation	DVSSEVSTLHKRKGR HCCHHHHHHHHHCCC	37.75	28555341
846	Phosphorylation	HKRKGRQSNWNPQHL HHHCCCCCCCCHHHH	42.31	24043423
862	Phosphorylation	ILQAQFASSLFQTSE HHHHHHHHHHHCCCC	28.94	24043423
863	Phosphorylation	LQAQFASSLFQTSEG HHHHHHHHHHCCCCC	29.76	24043423
867	Phosphorylation	FASSLFQTSEGKYLL HHHHHHCCCCCCEEH	22.78	24043423
868	Phosphorylation	ASSLFQTSEGKYLLS HHHHHCCCCCCEEHH	33.30	24043423
897	Phosphorylation	GLSMTTISHWLANVK CCCHHHHHHHHHHHH	13.40	27251275
965	Phosphorylation	RLSVDQQSKVEQEIS CCCHHHHHHHHHHHH	32.79	29396449
966	Sumoylation	LSVDQQSKVEQEISR CCHHHHHHHHHHHHH	45.51	28112733
975	Phosphorylation	EQEISRVSSAQRSPE HHHHHHHHHCCCCHH	20.88	26657352
976	Phosphorylation	QEISRVSSAQRSPET HHHHHHHHCCCCHHH	26.09	29396449
980	Phosphorylation	RVSSAQRSPETIAAE HHHHCCCCHHHHCCC	18.27	22167270
983	Phosphorylation	SAQRSPETIAAEEDT HCCCCHHHHCCCCCC	21.21	22167270
1016	Phosphorylation	VKLHLSKTHSKSPEH HHHHHCCCCCCCHHH	28.18	29449344
1018	Phosphorylation	LHLSKTHSKSPEHHS HHHCCCCCCCHHHHH	39.81	29214152
1020	Phosphorylation	LSKTHSKSPEHHSQF HCCCCCCCHHHHHHC	38.24	27732954
1025	Phosphorylation	SKSPEHHSQFVTDVD CCCHHHHHHCCCCCC	27.50	27732954
1029	Phosphorylation	EHHSQFVTDVDEE-- HHHHHCCCCCCCC--	31.43	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSH2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBB1_HUMAN	APBB1	physical	19343227

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.