dbPTM

TNR6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TNR6_MOUSE
UniProt AC	P25446
Protein Name	Tumor necrosis factor receptor superfamily member 6
Gene Name	Fas
Organism	Mus musculus (Mouse).
Sequence Length	327
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity)..
Protein Sequence	MLWIWAVLPLVLAGSQLRVHTQGTNSISESLKLRRRVRETDKNCSEGLYQGGPFCCQPCQPGKKKVEDCKMNGGTPTCAPCTEGKEYMDKNHYADKCRRCTLCDEEHGLEVETNCTLTQNTKCKCKPDFYCDSPGCEHCVRCASCEHGTLEPCTATSNTNCRKQSPRNRLWLLTILVLLIPLVFIYRKYRKRKCWKRRQDDPESRTSSRETIPMNASNLSLSKYIPRIAEDMTIQEAKKFARENNIKEGKIDEIMHDSIQDTAEQKVQLLLCWYQSHGKSDAYQDLIKGLKKAECRRTLDKFQDMVQKDLGKSTPDTGNENEGQCLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	GTNSISESLKLRRRV CCCCHHHHHHHHHHH	24.82	23140645
40	Phosphorylation	LRRRVRETDKNCSEG HHHHHHHCCCCCCCC	41.53	-
43	N-linked_Glycosylation	RVRETDKNCSEGLYQ HHHHCCCCCCCCCCC	37.04	-
45	Phosphorylation	RETDKNCSEGLYQGG HHCCCCCCCCCCCCC	44.06	-
49	Phosphorylation	KNCSEGLYQGGPFCC CCCCCCCCCCCCCCC	18.90	-
114	N-linked_Glycosylation	HGLEVETNCTLTQNT CCEEEECCEEECCCC	11.85	-
144	O-linked_Glycosylation	EHCVRCASCEHGTLE CCEEECCCCCCCCCC	24.54	30016717
154	O-linked_Glycosylation	HGTLEPCTATSNTNC CCCCCCCCCCCCCCC	43.62	30016717
194	S-palmitoylation	RKYRKRKCWKRRQDD HHHHHCHHHHHCCCC	6.34	17159908
204	Phosphorylation	RRQDDPESRTSSRET HCCCCCCCCCCCCCC	46.37	23684622
206	Phosphorylation	QDDPESRTSSRETIP CCCCCCCCCCCCCCC	40.09	27742792
207	Phosphorylation	DDPESRTSSRETIPM CCCCCCCCCCCCCCC	26.70	27742792
208	Phosphorylation	DPESRTSSRETIPMN CCCCCCCCCCCCCCC	33.26	27742792
211	Phosphorylation	SRTSSRETIPMNASN CCCCCCCCCCCCHHH	29.30	25521595
214	Oxidation	SSRETIPMNASNLSL CCCCCCCCCHHHCCH	6.06	17242355
217	Phosphorylation	ETIPMNASNLSLSKY CCCCCCHHHCCHHHH	33.04	27742792
220	Phosphorylation	PMNASNLSLSKYIPR CCCHHHCCHHHHHHH	34.54	25521595
222	Phosphorylation	NASNLSLSKYIPRIA CHHHCCHHHHHHHHH	21.75	27742792
224	Phosphorylation	SNLSLSKYIPRIAED HHCCHHHHHHHHHHH	16.87	20531401
238	Ubiquitination	DMTIQEAKKFARENN HCCHHHHHHHHHHCC	47.90	-
295	Glutathionylation	KGLKKAECRRTLDKF HHHHHHHHHHHHHHH	4.22	22833525
313	Phosphorylation	VQKDLGKSTPDTGNE HHHHHCCCCCCCCCC	43.29	17203969
314	Phosphorylation	QKDLGKSTPDTGNEN HHHHCCCCCCCCCCC	28.77	17203969
317	Phosphorylation	LGKSTPDTGNENEGQ HCCCCCCCCCCCCCC	43.01	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Marchf1	Q6NZQ8	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TNR6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TNR6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PML_MOUSE	Pml	physical	21803845
FADD_HUMAN	FADD	physical	10542291
FEM1B_HUMAN	FEM1B	physical	10542291
CASP8_MOUSE	Casp8	physical	21382479
FADD_MOUSE	Fadd	physical	21382479
DAXX_HUMAN	DAXX	physical	11483955
DAXX_MOUSE	Daxx	physical	11483955

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TNR6_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-206; SER-217 ANDSER-222, AND MASS SPECTROMETRY.	19144319 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220, AND MASSSPECTROMETRY.	17242355 [Abstract]