SUMO3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUMO3_MOUSE
• UniProt AC: Q9Z172
• Protein Name: Small ubiquitin-related modifier 3 {ECO:0000305}
• Gene Name: Sumo3 {ECO:0000312|MGI:MGI:1336201}
• Organism: Mus musculus (Mouse).
• Sequence Length: 110
• Subcellular Localization: Cytoplasm. Nucleus. Nucleus, PML body .
• Protein Description: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity)..
• Protein Sequence: MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGSASRGSVPTPNRCPDLCY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEEKPKEG ------CCCCCCCCC	55.23	25266776
11	Ubiquitination	EKPKEGVKTENDHIN CCCCCCCCCCCCCEE	62.06	-
11	Acetylation	EKPKEGVKTENDHIN CCCCCCCCCCCCCEE	62.06	23806337
12	Phosphorylation	KPKEGVKTENDHINL CCCCCCCCCCCCEEE	37.30	24719451
27	Phosphorylation	KVAGQDGSVVQFKIK EEECCCCCEEEEEEE	27.66	26824392
32	Ubiquitination	DGSVVQFKIKRHTPL CCCEEEEEEECCCHH	30.17	-
34	Ubiquitination	SVVQFKIKRHTPLSK CEEEEEEECCCHHHH	38.42	-
37	Phosphorylation	QFKIKRHTPLSKLMK EEEEECCCHHHHHHH	29.92	22817900
41	Ubiquitination	KRHTPLSKLMKAYCE ECCCHHHHHHHHHHH	61.35	-
44	Ubiquitination	TPLSKLMKAYCERQG CHHHHHHHHHHHHCC	46.79	-
53	Phosphorylation	YCERQGLSMRQIRFR HHHHCCCCCEEEEEE	20.81	24719451
95	Phosphorylation	QQTGGSASRGSVPTP HHHCCCCCCCCCCCC	38.58	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUMO3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUMO3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUMO3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SENP6_MOUSE	Senp6	physical	23825957
XIAP_HUMAN	XIAP	physical	26496610
GABP1_HUMAN	GABPB1	physical	26496610
ITPR2_HUMAN	ITPR2	physical	26496610
RPAB2_HUMAN	POLR2F	physical	26496610
RENT1_HUMAN	UPF1	physical	26496610
SMC1A_HUMAN	SMC1A	physical	26496610
GT2D1_HUMAN	GTF2IRD1	physical	26496610
SAE1_HUMAN	SAE1	physical	26496610
EXOC3_HUMAN	EXOC3	physical	26496610
INT7_HUMAN	INTS7	physical	26496610
RM18_HUMAN	MRPL18	physical	26496610
RCC2_HUMAN	RCC2	physical	26496610
TBC14_HUMAN	TBC1D14	physical	26496610
RT35_HUMAN	MRPS35	physical	26496610
UTP15_HUMAN	UTP15	physical	26496610
SFXN1_HUMAN	SFXN1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.