TBC14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBC14_HUMAN
• UniProt AC: Q9P2M4
• Protein Name: TBC1 domain family member 14
• Gene Name: TBC1D14
• Organism: Homo sapiens (Human).
• Sequence Length: 693
• Subcellular Localization: Golgi apparatus, cis-Golgi network . Golgi apparatus, trans-Golgi network . After amino acid starvation, Golgi apparatus-associated protein levels increase compared with fed conditions. May be cycling between the Golgi apparatus and an endosomal pool
• Protein Description: Negative regulator of starvation-induced autophagosome formation..
• Protein Sequence: MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDLVVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTDGKLSTS ------CCCCCCCCC	54.16	-
7	Phosphorylation	-MTDGKLSTSTNGVA -CCCCCCCCCCCCEE	24.65	27251275
8	Phosphorylation	MTDGKLSTSTNGVAF CCCCCCCCCCCCEEE	50.43	27251275
9	Phosphorylation	TDGKLSTSTNGVAFM CCCCCCCCCCCEEEE	19.25	27251275
10	Phosphorylation	DGKLSTSTNGVAFMG CCCCCCCCCCEEEEE	35.76	27251275
15 (in isoform 2)	Phosphorylation	-	4.24	24719451
15	Phosphorylation	TSTNGVAFMGILDGR CCCCCEEEEEEECCC	4.24	24719451
42	Phosphorylation	LKAPRLLSAPEYGPK CCCCCHHCCCCCCCH	46.50	29396449
46	Phosphorylation	RLLSAPEYGPKLKLR CHHCCCCCCCHHHHH	37.35	29396449
60	Phosphorylation	RALEDRHSLQSVDSG HHHHCHHHHCCCCCC	29.06	28348404
63	Phosphorylation	EDRHSLQSVDSGIPT HCHHHHCCCCCCCCE	32.93	28348404
82	Phosphorylation	NPEPVPCSAVHVRRK CCCCCCCCEEEEEEC	27.53	26074081
91	Phosphorylation	VHVRRKQSDSDLIPE EEEEECCCCCCCCCH	41.96	23401153
93	Phosphorylation	VRRKQSDSDLIPERA EEECCCCCCCCCHHH	39.29	29255136
103	Phosphorylation	IPERAFQSACALPSC CCHHHHHHHCCCCCC	20.89	25850435
109	Phosphorylation	QSACALPSCAPPAPS HHHCCCCCCCCCCCC	24.62	27080861
123	Phosphorylation	SSTEREQSVRKSSTF CCCHHHHHHHHCCCC	21.09	25627689
127	Phosphorylation	REQSVRKSSTFPRTG HHHHHHHCCCCCCCC	24.85	28060719
128	Phosphorylation	EQSVRKSSTFPRTGY HHHHHHCCCCCCCCC	36.78	28060719
129	Phosphorylation	QSVRKSSTFPRTGYD HHHHHCCCCCCCCCC	44.76	28060719
133	Phosphorylation	KSSTFPRTGYDSVKL HCCCCCCCCCCEEEE	40.09	23898821
135	Phosphorylation	STFPRTGYDSVKLYS CCCCCCCCCEEEEEC	12.39	28796482
137	Phosphorylation	FPRTGYDSVKLYSPT CCCCCCCEEEEECCC	16.81	-
141	Phosphorylation	GYDSVKLYSPTSKAL CCCEEEEECCCCCCC	13.59	23312004
142	Phosphorylation	YDSVKLYSPTSKALT CCEEEEECCCCCCCC	31.94	23312004
144	Phosphorylation	SVKLYSPTSKALTRS EEEEECCCCCCCCCC	36.60	23312004
145	Phosphorylation	VKLYSPTSKALTRSD EEEECCCCCCCCCCC	21.22	23312004
206	Phosphorylation	QFTNVTLSSIKETRG CCCEEEHHHHHHHCC	22.20	24719451
228	Ubiquitination	HEAEEGSKLKILGPF HHCCCCCCCEEEEHH	65.73	-
249	Phosphorylation	NLLARKQSARLDKHN HHHHHHHHHCCCCCC	20.56	23882029
254	Ubiquitination	KQSARLDKHNDLGWK HHHHCCCCCCCHHHH	49.23	-
261	Ubiquitination	KHNDLGWKLFGKAPL CCCCHHHHHHCCCCC	31.94	-
291	Phosphorylation	EDKAGRPSKPPSPKQ HHHCCCCCCCCCCCC	57.33	23403867
292	Acetylation	DKAGRPSKPPSPKQN HHCCCCCCCCCCCCC	64.73	7427447
295	Phosphorylation	GRPSKPPSPKQNVRK CCCCCCCCCCCCHHH	53.94	23927012
338	Phosphorylation	AQKHRQQYEEMVVQA HHHHHHHHHHHHHHH	12.91	28796482
439	Phosphorylation	RAKERWRSLSTGGSE HHHHHHHHCCCCCCC	21.51	28450419
441	Phosphorylation	KERWRSLSTGGSEVE HHHHHHCCCCCCCCC	26.67	28450419
442	Phosphorylation	ERWRSLSTGGSEVEN HHHHHCCCCCCCCCC	51.35	28450419
445	Phosphorylation	RSLSTGGSEVENEDA HHCCCCCCCCCCCCC	39.55	28450419
643	Phosphorylation	IHMAQFLTRLPEDLP HHHHHHHHCCCCCCC	31.30	-
679	2-Hydroxyisobutyrylation	QVLTALQKDSREMEK HHHHHHHHHHHHHHC	59.53	-
688	Phosphorylation	SREMEKGSPSLRH-- HHHHHCCCCCCCC--	23.53	23401153
690	Phosphorylation	EMEKGSPSLRH---- HHHCCCCCCCC----	39.47	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBC14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBC14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBC14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPC11_HUMAN	TRAPPC11	physical	28514442
TPC12_HUMAN	TRAPPC12	physical	28514442
TPC13_HUMAN	TRAPPC13	physical	28514442
ARBK1_HUMAN	ADRBK1	physical	28514442
TPPC8_HUMAN	TRAPPC8	physical	28514442
TPPC4_HUMAN	TRAPPC4	physical	28514442
TPPC3_HUMAN	TRAPPC3	physical	28514442
TPC6B_HUMAN	TRAPPC6B	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
TPC2A_HUMAN	TRAPPC2	physical	28514442
TPC2B_HUMAN	TRAPPC2	physical	28514442
TPPC9_HUMAN	TRAPPC9	physical	28514442
TPPC5_HUMAN	TRAPPC5	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
TPC2L_HUMAN	TRAPPC2L	physical	28514442
TPC10_HUMAN	TRAPPC10	physical	28514442
TPPC1_HUMAN	TRAPPC1	physical	28514442
TRHY_HUMAN	TCHH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.