C8AP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C8AP2_MOUSE
• UniProt AC: Q9WUF3
• Protein Name: CASP8-associated protein 2
• Gene Name: Casp8ap2 {ECO:0000312|MGI:MGI:1349399}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1962
• Subcellular Localization: Cytoplasm. Nucleus . Nucleus, PML body. Mitochondrion. Exported from the nucleus to the mitochondria upon FAS activation..
• Protein Description: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity). Required for histone gene transcription and progression through S phase (By similarity). Required for histone gene transcription and S phase progression (By similarity). Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis..
• Protein Sequence: MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSAVSDSTARSCVSFRNCLDLYEEILTEEGTAKEATYNDLQIEYGKCQQQMKDLMKRFKEIQTQNLNLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSQSTSPHLDDCSKTDHGVKSDVQKDVHPNTAQPNLEKEGKSHSEAQNPLHLSTGVEKHCANNVWSRSPYQVGEGNSNEDNRRGRSGTRHSQCSRGTDRTQKDLHSSCNDSEPRDKEANSRLQGHPEKHGNSEARTESKISESKSSTGMGYKSERSASSWEKETSRERPHTRVESQHDKNLEKQNERLQNMHRKELPSQDKTERKVDVKFKPAGEEQGHRGRVDRALPPHPKNDVKHYGFNKYHPEERRGREDCKRDRGMNSHGFQDRRCSSFLSSNRNSKYPHSKEVSVAHQWENTPFKAERHRTEDRRKRERENKEESRHVKSDKKSPPEHLQRTHKDTKKSTADGKRQTEPKHGKGAVSNSELSKGTDSKEGATKVESGPNEAKGKDLKLSFMEKLNLTLSPAKKQPACQDNPHQITGVPEPSGTCDSRSLETTGTVACLPSGSEHNREETKSELPEPKEALLATSQLRISIPENKMKEEKRLLFKSVENTVPCELLACGTEISLPAPVEIEQARCLLGSVEVEETCGGARTAASVVMHVLPEHASEDASQELDTKRHDGINACAISEGVKTKVILSPKAAAASESHLAPLVEEPSISLVNCSGDNNPKLEPSLEERPIVETKSCPLESCLPKETFVPSPQKTELIDHKIETGESNSVYQDDDNSVLSIDFNNLRPIPDPISPLNSPVRPVCKVVSMESSCAIPLYDSSHKDEFPSNSTLSTFKSQSDLNKENEKPVPKFDKCSEADSCKHLSLDELEEGEIRSDDEESVAQKRLEKSARPRVSAEVQPGKSSPGSRRSTVHVHKDNGRTAVKLPRDRLTWSKRSSESRPSNTERKSKTMSISSLEKILPLILVPSSLWEVMHMLRLLGKHVRKNYMKFKIKFSLTQFHRIIESAILSFTSLVKCLDLSKICKSVSTLQKSLCEVIESNLKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQLDYLFEKLKKILLKFCDSVNFENENSEGKLGKKYKERTQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKSEEKHQDQNKTNASIVKHDVKRTFSTCSDNTKNAECKEQFLEKSCPSTPRPGKDEGHTEEEAQAAQHASAKSERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDTSGTEKAEWELKTPEKQLLESLKCESAPACATEELVSEGASLCPKVISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDENCMFEVSSNTALGKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHLSFLKPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSRSVASGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSPGLKHGVVAEESLTSLPRTGKEAGVATEKEPNLFQSTVLKPVKDLENTDKNIDKSKLTHEEQNSIVQTQVPDIYEFLKDASNKVVHCDQVVDDCFKLHQVWEPKVSENLQELPSMEKIPHSLDNHLPDTHIDLTKDSATETKSLGELMEVTVLNVDHLECSQTNLDQDAEITCSSLQPDTIDAFIDLTHDASSESKNEGSEPVLAVEGMGCQVICIDEDTNKEGKMGRANSPLESIVEETCIDLTSESPGSCEIKRHNLKSEPPSKLDCLELPETLGNGHKKRKNSPGVSHSSQKKQRKDIDLSSEKTQRLSPNSDRNGDAHRKQASKKREPAVNETSLSSEASPEVKGSTAVLAASPASLSAKNVIKKKGEIIVSWTRNDDREILLECQKRMPSLKTFTYLAVKLNKNPNQVSERFQQLKKLFEKSKCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAADDDNGD ------CCCCCCCCC	30.79	-
20	Phosphorylation	LFDVCPASPLKNNDE CCEECCCCCCCCCCC	18.86	26745281
116	Phosphorylation	QSLKKNISALIKTAR HHHHHHHHHHHHHHH	26.81	25619855
162	Phosphorylation	TKDSQSTSPHLDDCS CCCCCCCCCCHHHCC	18.64	27841257
320	Phosphorylation	ASSWEKETSRERPHT CCCCCCHHCCCCCCC	44.12	25777480
321	Phosphorylation	SSWEKETSRERPHTR CCCCCHHCCCCCCCH	32.98	25777480
327	Phosphorylation	TSRERPHTRVESQHD HCCCCCCCHHHHHHH	38.81	25777480
481	Phosphorylation	EESRHVKSDKKSPPE HHHHHCCCCCCCCHH	54.28	25266776
485	Phosphorylation	HVKSDKKSPPEHLQR HCCCCCCCCHHHHHH	51.97	27600695
558	Phosphorylation	FMEKLNLTLSPAKKQ HHHHHCCCCCCCCCC	24.90	25159016
560	Phosphorylation	EKLNLTLSPAKKQPA HHHCCCCCCCCCCCC	19.99	26824392
582	Phosphorylation	ITGVPEPSGTCDSRS CCCCCCCCCCCCCCC	45.10	-
736	Phosphorylation	VKTKVILSPKAAAAS CCEEEEECHHHHHCC	17.15	28833060
794	Phosphorylation	ESCLPKETFVPSPQK HHCCCCCCCCCCCCC	35.74	22942356
798	Phosphorylation	PKETFVPSPQKTELI CCCCCCCCCCCCEEE	34.36	26824392
802	Phosphorylation	FVPSPQKTELIDHKI CCCCCCCCEEEEEEE	30.67	25266776
841	Phosphorylation	RPIPDPISPLNSPVR EECCCCCCCCCCCCC	28.82	26370283
845	Phosphorylation	DPISPLNSPVRPVCK CCCCCCCCCCCCCEE	32.24	26370283
858	Phosphorylation	CKVVSMESSCAIPLY EEEEECCCCCEEECC	23.29	-
912	Phosphorylation	ADSCKHLSLDELEEG CCCCCCCCHHHHHCC	33.23	25619855
923	Phosphorylation	LEEGEIRSDDEESVA HHCCCCCCCCHHHHH	55.89	25619855
928	Phosphorylation	IRSDDEESVAQKRLE CCCCCHHHHHHHHHH	22.24	25619855
951	Phosphorylation	AEVQPGKSSPGSRRS CEECCCCCCCCCCCC	47.91	25159016
952	Phosphorylation	EVQPGKSSPGSRRST EECCCCCCCCCCCCE	36.44	25159016
955	Phosphorylation	PGKSSPGSRRSTVHV CCCCCCCCCCCEEEE	28.09	25338131
1093	Acetylation	ESNLKQVKKNGIVDR HHHHHHHHHCCHHHH	37.72	7629417
1220	Phosphorylation	HDVKRTFSTCSDNTK HHHHHHHHCCCCCCC	28.08	25266776
1303	Phosphorylation	FKSLLQGSDLLDTSG HHHHHCCCCCCCCCC	16.48	24759943
1308	Phosphorylation	QGSDLLDTSGTEKAE CCCCCCCCCCCCCCE	29.08	24759943
1309	Phosphorylation	GSDLLDTSGTEKAEW CCCCCCCCCCCCCEE	43.30	24759943
1311	Phosphorylation	DLLDTSGTEKAEWEL CCCCCCCCCCCEEEE	33.80	26643407
1320	Phosphorylation	KAEWELKTPEKQLLE CCEEEECCCHHHHHH	49.67	26745281
1323	Acetylation	WELKTPEKQLLESLK EEECCCHHHHHHHCC	47.66	23806337
1355	Phosphorylation	SLCPKVISDDNWSLL CCCCEEECCCCCHHH	41.73	28066266
1360	Phosphorylation	VISDDNWSLLSSEKG EECCCCCHHHCCCCC	26.20	21082442
1363	Phosphorylation	DDNWSLLSSEKGPSL CCCCHHHCCCCCCCC	41.57	21149613
1364	Phosphorylation	DNWSLLSSEKGPSLS CCCHHHCCCCCCCCC	43.21	21149613
1487	Phosphorylation	DNSSSKSSCSSWTSR CCCCCCCCCCCCCCC	23.04	-
1516	Phosphorylation	HAVIMEKSNDHFIVK EEEEEECCCCEEEEE	33.90	26824392
1528	Phosphorylation	IVKIRRATPSTSPGL EEEEEECCCCCCCCH	18.89	22817900
1530	Phosphorylation	KIRRATPSTSPGLKH EEEECCCCCCCCHHC	36.84	29895711
1531	Phosphorylation	IRRATPSTSPGLKHG EEECCCCCCCCHHCC	39.89	29895711
1532	Phosphorylation	RRATPSTSPGLKHGV EECCCCCCCCHHCCE	22.70	29895711
1536	Acetylation	PSTSPGLKHGVVAEE CCCCCCHHCCEEEHH	44.20	23806337
1544	Phosphorylation	HGVVAEESLTSLPRT CCEEEHHHHCCCCCC	28.58	27600695
1546	Phosphorylation	VVAEESLTSLPRTGK EEEHHHHCCCCCCCC	37.18	28066266
1547	Phosphorylation	VAEESLTSLPRTGKE EEHHHHCCCCCCCCC	41.49	29550500
1568	Phosphorylation	KEPNLFQSTVLKPVK CCCCCCCCCCCCCHH	17.10	-
1763	Phosphorylation	GKMGRANSPLESIVE CCCCCCCCCHHHHHH	29.85	21659605
1767	Phosphorylation	RANSPLESIVEETCI CCCCCHHHHHHHHHE	39.35	26745281
1780	Phosphorylation	CIDLTSESPGSCEIK HEECCCCCCCCCEEE	34.04	21082442
1783	Phosphorylation	LTSESPGSCEIKRHN CCCCCCCCCEEECCC	16.38	24224561
1818	Phosphorylation	GHKKRKNSPGVSHSS CCCCCCCCCCCCCCH	26.51	25266776
1822	Phosphorylation	RKNSPGVSHSSQKKQ CCCCCCCCCCHHHHH	24.46	28066266
1824	Phosphorylation	NSPGVSHSSQKKQRK CCCCCCCCHHHHHHC	27.27	25266776
1825	Phosphorylation	SPGVSHSSQKKQRKD CCCCCCCHHHHHHCC	40.36	25266776
1836	Phosphorylation	QRKDIDLSSEKTQRL HHCCCCCCCHHHHCC	32.47	-
1837	Phosphorylation	RKDIDLSSEKTQRLS HCCCCCCCHHHHCCC	50.86	-
1844	Phosphorylation	SEKTQRLSPNSDRNG CHHHHCCCCCCCCCC	24.99	25266776
1849	Methylation	RLSPNSDRNGDAHRK CCCCCCCCCCHHHHH	49.18	-
1869	Phosphorylation	REPAVNETSLSSEAS CCCCCCCCCCCCCCC	29.75	28066266
1870	Phosphorylation	EPAVNETSLSSEASP CCCCCCCCCCCCCCC	21.78	28066266
1872	Phosphorylation	AVNETSLSSEASPEV CCCCCCCCCCCCCCC	26.37	25619855
1873	Phosphorylation	VNETSLSSEASPEVK CCCCCCCCCCCCCCC	42.34	28066266
1876	Phosphorylation	TSLSSEASPEVKGST CCCCCCCCCCCCCCC	19.97	25619855
1889	Phosphorylation	STAVLAASPASLSAK CCHHHEECHHHHCCH	18.52	25266776
1892	Phosphorylation	VLAASPASLSAKNVI HHEECHHHHCCHHHH	26.66	28066266
1894	Phosphorylation	AASPASLSAKNVIKK EECHHHHCCHHHHHH	34.40	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C8AP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C8AP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C8AP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of C8AP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.