dbPTM

ASCL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASCL1_MOUSE
UniProt AC	Q02067
Protein Name	Achaete-scute homolog 1 {ECO:0000303\|PubMed:8217843, ECO:0000303\|PubMed:8424959}
Gene Name	Ascl1 {ECO:0000312\|MGI:MGI:96919}
Organism	Mus musculus (Mouse).
Sequence Length	231
Subcellular Localization	Nucleus .
Protein Description	Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. [PubMed: 24243019 Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes]
Protein Sequence	MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAQSAQQQQPQAPPQQAPQLSPVADSQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
150	Phosphorylation	GAANKKMSKVETLRS CHHHCCCCHHHHHHH	42.29	15318167
151	Acetylation	AANKKMSKVETLRSA HHHCCCCHHHHHHHH	40.36	23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
150	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
150	S	Phosphorylation	Kinase	CSNK2A1	Q60737	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ASCL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASCL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFE2_MOUSE	Tcf3	physical	20211142
TFE2_MOUSE	Tcf3	physical	12217327
TFE2_MOUSE	Tcf3	physical	8948587
HTF4_MOUSE	Tcf12	physical	8948587
HAND1_MOUSE	Hand1	physical	8948587
NGN2_MOUSE	Neurog2	physical	8948587

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASCL1_MOUSE

Related Literatures of Post-Translational Modification