JADE1_MOUSE - dbPTM
JADE1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID JADE1_MOUSE
UniProt AC Q6ZPI0
Protein Name Protein Jade-1
Gene Name Jade1
Organism Mus musculus (Mouse).
Sequence Length 834
Subcellular Localization Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, cilium basal body . Localizes to the ciliary transition zone.
Protein Description Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity)..
Protein Sequence MKRGRLPSSSEDSDDNGSLSTTWSQHSRSQHGRSSTCSRPEDRKPSEVFRTDLITAMKLHDSYQLNPDDYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIASSGSEPPALGYVDIRTLADSVCRYDLNDMDAAWLEVTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEEGLGEGAAQENGAPESSPQSPLEPYGSLEPNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKINFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFTQYTKLLEQEKVSGVPSSCSSALENMLFFNSPSVGPNAPKIEDLKWHSAFFRKQMGTSLVHPLKKSHKRDAVQNSSGTEGKTSHKQPGLCGRREGLEVSESLLSLEKTFAEARLLSSAQQKNGVVTPDHGKRRDNRFHCDLVKGDLKDKSFKQSHKPLRSTDTSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLVKVPITPASPVKSWGGFRIPKKGERQQQGEAHDGACHQHSDCSHLGVSRAPAKERAKSRLRADSENDGYAPDGEMSDSESEASEKKCIHASSTISRRTDIIRRSILAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMKRGRLPSSSEDSDD
CCCCCCCCCCCCCCC		51.6022817900
10PhosphorylationRGRLPSSSEDSDDNG
CCCCCCCCCCCCCCC		50.16-
13PhosphorylationLPSSSEDSDDNGSLS
CCCCCCCCCCCCCCC		42.69-
90PhosphorylationKGVQVPVSPGTIPQP
CCCCCCCCCCCCCCC		16.1326824392
93PhosphorylationQVPVSPGTIPQPVAR
CCCCCCCCCCCCCEE		32.6321149613
250PhosphorylationEGSWLCRTCALGVQP
CCCEEECCCCCCCCC		10.9228059163
272PhosphorylationKGGAMKPTRSGTKWV
CCCCCCCCCCCCCEE		31.7619854140
274PhosphorylationGAMKPTRSGTKWVHV
CCCCCCCCCCCEEEE		53.9819854140
276PhosphorylationMKPTRSGTKWVHVSC
CCCCCCCCCEEEEEE		23.9922817900
291PhosphorylationALWIPEVSIGSPEKM
EEECCCCCCCCHHHC		21.4126643407
294PhosphorylationIPEVSIGSPEKMEPI
CCCCCCCCHHHCCCC		28.3726643407
302PhosphorylationPEKMEPITKVSHIPS
HHHCCCCCEECCCCH		35.7926745281
303AcetylationEKMEPITKVSHIPSS
HHCCCCCEECCCCHH		42.3223806337
317PhosphorylationSRWALVCSLCNEKFG
HHHHHHHHHCCCHHC		28.6021454597
393PhosphorylationENGAPESSPQSPLEP
HCCCCCCCCCCCCCC		25.8719854140
396PhosphorylationAPESSPQSPLEPYGS
CCCCCCCCCCCCCCC		34.5321149613
456UbiquitinationDFLYQYWKLKRKINF
HHHHHHHHHHHHCCC		38.92-
458UbiquitinationLYQYWKLKRKINFNK
HHHHHHHHHHCCCCC		48.17-
581UbiquitinationWHSAFFRKQMGTSLV
HHHHHHHHHHCCCHH		39.21-
603PhosphorylationKRDAVQNSSGTEGKT
CCCCCCCCCCCCCCC		17.04-
604PhosphorylationRDAVQNSSGTEGKTS
CCCCCCCCCCCCCCC		58.2325266776
609AcetylationNSSGTEGKTSHKQPG
CCCCCCCCCCCCCCC		40.3923806337
678PhosphorylationKGDLKDKSFKQSHKP
CCCCCCCCHHHCCCC		48.0529472430
682PhosphorylationKDKSFKQSHKPLRST
CCCCHHHCCCCCCCC		33.7829472430
703PhosphorylationLDNTRAATSPGVGQS
HHCCCCCCCCCCCCC		34.1721149613
704PhosphorylationDNTRAATSPGVGQSA
HCCCCCCCCCCCCCC		18.2221149613
710PhosphorylationTSPGVGQSAPGTRKE
CCCCCCCCCCCCCCC		30.4221149613
714PhosphorylationVGQSAPGTRKEIVPK
CCCCCCCCCCCCCCC		37.1927149854
725PhosphorylationIVPKCNGSLVKVPIT
CCCCCCCCEEEEECC		18.9228285833
732PhosphorylationSLVKVPITPASPVKS
CEEEEECCCCCCCCC		13.5125159016
735PhosphorylationKVPITPASPVKSWGG
EEECCCCCCCCCCCC		31.2826824392
739PhosphorylationTPASPVKSWGGFRIP
CCCCCCCCCCCEECC		31.0522006019
790PhosphorylationKSRLRADSENDGYAP
HHHHHCCCCCCCCCC		37.0021149613
795PhosphorylationADSENDGYAPDGEMS
CCCCCCCCCCCCCCC		20.1626643407
802PhosphorylationYAPDGEMSDSESEAS
CCCCCCCCCCCCHHH		33.4121149613
804PhosphorylationPDGEMSDSESEASEK
CCCCCCCCCCHHHHH		35.4021149613
806PhosphorylationGEMSDSESEASEKKC
CCCCCCCCHHHHHHH		42.2729550500
809PhosphorylationSDSESEASEKKCIHA
CCCCCHHHHHHHHHH		45.9929550500
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of JADE1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of JADE1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of JADE1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of JADE1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of JADE1_MOUSE

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Related Literatures of Post-Translational Modification

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