BHE41_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BHE41_MOUSE
• UniProt AC: Q99PV5
• Protein Name: Class E basic helix-loop-helix protein 41
• Gene Name: Bhlhe41
• Organism: Mus musculus (Mouse).
• Sequence Length: 410
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity..
• Protein Sequence: MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVSHLHAVATQLLTPQVPSGRGSGRAPCSAGAAAASGPERVARCVPVIQRTQPGTEPEHDTDTDSGYGGEAEQGRAAVKQEPPGDSSPAPKRPKLEARGALLGPEPALLGSLVALGGGAPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIPAAAAAAAAAAFPCLSSVLSPPPEKAGATAGAPFLAHEVAPPGPLRPQHAHSRTHLPRAVNPESSQEDATQPAKDAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
119	Phosphorylation	ALQNGERSLKSPVQA CCCCCCCCCCCCCHH	35.53	24719451
121	Acetylation	QNGERSLKSPVQADL CCCCCCCCCCCHHCH	54.69	7718667
122	Phosphorylation	NGERSLKSPVQADLD CCCCCCCCCCHHCHH	35.28	25521595
140	Acetylation	SGFQTCAKEVLQYLA HHHHHHHHHHHHHHH	50.97	7718679
164	Phosphorylation	PRCAQLVSHLHAVAT HHHHHHHHHHHHHHH	28.99	22817900
171	Phosphorylation	SHLHAVATQLLTPQV HHHHHHHHHHHCCCC	17.10	22817900
175	Phosphorylation	AVATQLLTPQVPSGR HHHHHHHCCCCCCCC	21.92	22817900
212	Phosphorylation	CVPVIQRTQPGTEPE HHEEEEECCCCCCCC	23.80	26643407
216	Phosphorylation	IQRTQPGTEPEHDTD EEECCCCCCCCCCCC	55.86	26643407
222	Phosphorylation	GTEPEHDTDTDSGYG CCCCCCCCCCCCCCC	42.58	26643407
224	Phosphorylation	EPEHDTDTDSGYGGE CCCCCCCCCCCCCCC	33.87	26643407
226	Phosphorylation	EHDTDTDSGYGGEAE CCCCCCCCCCCCCHH	35.69	26643407
247	Phosphorylation	KQEPPGDSSPAPKRP CCCCCCCCCCCCCCC	44.10	30635358
248	Phosphorylation	QEPPGDSSPAPKRPK CCCCCCCCCCCCCCC	29.80	30635358
397	Phosphorylation	PRAVNPESSQEDATQ CCCCCCCCCCCCCCC	38.28	30635358
398	Phosphorylation	RAVNPESSQEDATQP CCCCCCCCCCCCCCC	35.61	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BHE41_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BHE41_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BHE41_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFE2_MOUSE	Tcf3	physical	12657651
MYOD1_MOUSE	Myod1	physical	12657651

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.