PSD13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSD13_MOUSE
• UniProt AC: Q9WVJ2
• Protein Name: 26S proteasome non-ATPase regulatory subunit 13
• Gene Name: Psmd13
• Organism: Mus musculus (Mouse).
• Sequence Length: 376
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
• Protein Sequence: MKDVPAFLQQSQSSGPGQAAVWHRLEELYTKKLWHQLTLEVLDFVQDPCFAQGDGLIKLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGALKLNIGDLQATKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRDTDRQWLIDTLYAFNSGAVDRFQTLKCAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSAKITVNKVELLVMKALSVGLVRGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLELWCTDVKSMEMLVEHQAQDILT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKDVPAFLQ ------CCCHHHHHH	68.39	-
31	Acetylation	RLEELYTKKLWHQLT HHHHHHHHHHHHHHH	32.10	22826441
31	Ubiquitination	RLEELYTKKLWHQLT HHHHHHHHHHHHHHH	32.10	-
99	Acetylation	VALTFLEKTREKVKS HHHHHHHHHHHHHCC	55.84	23954790
99	Ubiquitination	VALTFLEKTREKVKS HHHHHHHHHHHHHCC	55.84	-
105	Ubiquitination	EKTREKVKSSDEAVI HHHHHHHCCCCHHHH	56.14	-
115	Ubiquitination	DEAVILCKTAIGALK CHHHHHCHHHHHHHH	37.23	-
122	Acetylation	KTAIGALKLNIGDLQ HHHHHHHHCCHHCHH	38.67	23954790
122	Ubiquitination	KTAIGALKLNIGDLQ HHHHHHHHCCHHCHH	38.67	-
161	Ubiquitination	RFYDLSSKYYQTIGN HHHCCCCCHHHHHCC	44.60	-
161	Acetylation	RFYDLSSKYYQTIGN HHHCCCCCHHHHHCC	44.60	22826441
174	Ubiquitination	GNHASYYKDALRFLG CCCHHHHHHHHHHCC	28.43	-
174	Acetylation	GNHASYYKDALRFLG CCCHHHHHHHHHHCC	28.43	23954790
186	Ubiquitination	FLGCVDIKDLPVSEQ HCCCEECCCCCCCHH	49.07	-
186	Acetylation	FLGCVDIKDLPVSEQ HCCCEECCCCCCCHH	49.07	22826441
281	Phosphorylation	LLCLMEMTFTRPANH HHHHHHCCCCCCCCC	14.46	29514104
298	Ubiquitination	LTFEEIAKSAKITVN CCHHHHHHHCCCEEC	57.52	-
298	Acetylation	LTFEEIAKSAKITVN CCHHHHHHHCCCEEC	57.52	23954790
301	Malonylation	EEIAKSAKITVNKVE HHHHHHCCCEECHHH	46.10	26320211
306	Malonylation	SAKITVNKVELLVMK HCCCEECHHHHHHHH	32.52	26320211
306	Acetylation	SAKITVNKVELLVMK HCCCEECHHHHHHHH	32.52	23236377
313	Ubiquitination	KVELLVMKALSVGLV HHHHHHHHHHHHCCC	38.40	-
329	Acetylation	GSIDEVDKRVHMTWV CCHHHHHHHHHHHEE	62.59	23954790
347	Ubiquitination	VLDLQQIKGMKDRLE CCCHHHHCCCHHHHH	48.92	-
347	Acetylation	VLDLQQIKGMKDRLE CCCHHHHCCCHHHHH	48.92	23954790
357	S-palmitoylation	KDRLELWCTDVKSME HHHHHHHCCCHHHHH	3.49	28526873
357	S-nitrosylation	KDRLELWCTDVKSME HHHHHHHCCCHHHHH	3.49	20925432
357	S-nitrosocysteine	KDRLELWCTDVKSME HHHHHHHCCCHHHHH	3.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSD13_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSD13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSD13_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSD13_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.