REV3L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REV3L_MOUSE
• UniProt AC: Q61493
• Protein Name: DNA polymerase zeta catalytic subunit
• Gene Name: Rev3l
• Organism: Mus musculus (Mouse).
• Sequence Length: 3122
• Subcellular Localization: Nucleus .
• Protein Description: Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function..
• Protein Sequence: MFSVRIVTADYYMASPLPGLDTCQSPLTQLPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPAMVKRICELLQSGAIMNKCYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKARRKGNASHATGLFKHQLSGNSPAGTLFRWEEDEIPSSLLLEGVEPLSTCELEVDAVAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRNESSQISQPESQDCRFVPATESEKQFQKRLQEVLKQNDFSVTLSGSVDYSNGSQEFSAELTLHSEILSPEMLPCSPANMIEVHKDTDLSKGNTKHKVEEALINEEAILNLIENSQTFQPLTQRLSETPVFMGSSPDESLVHLLAGLESDGYQGEKNRMPLPCHSFGESQNPQNSDDEENEPQIEKEEMELSVVMSQRWDSDIEEHCAKKRSLCRNAHRSSTEEDDSSSEEEMEWTDNSLLFANLSIPQLDGTADENSDNPLNNENSRAHSSVIATSKLSVRPSIFHKDAATLEPPSSAKITFQCKHTSALSSHVLNKDGLTEDLSQPNSTEKGRDNSVTFTKESTYSMKYSGSLSSTVHSDNSHKEICKKDKSLPVSSCESSVFDYEEDIPSVTRQVPSRKYSNMRKIEKDASCIHVNRHISETILGKNSFNFADLNHSKRKLSSEGNEKGNSTSLSGVFPSSLTENCDLLPSSGENRSMAHSLESITDESGLNKLKIRYEEFQEHKMEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQSGNKPSRLKLNKKKLIGLQETSTKSTETGATKDSCTHNDLYTGASEKENGLSSDSAKATHGTFENKPPTEHFIDCHFGDGSLEAEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTQNSKISLPHPMEIGENLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKPGKQHRTNSENIKRTLSFRKKRTHAVLSPPSPSYIAETEDCDLSYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIMAAAEKESMLFKGPNVYNTKTVSPRVGKASRARAQVKKSKARLANSSVVTNKRNKRNQTTKLVDDGKKKPRAKQKQRANEKSLSRKHAIPADEKMKPHSEAELTPNHQSVSELTSSSGAQALSKQKEMSQTGPAVDHPLPPAQPTGISAQQRLSNCFSSFLESKKSVDLRTFPSSRDDSHSSVVYSSIGPGISKINIQRSHNQSAMFTRKETTLIQKSIFDLSNHLSQVAQSTQVCSGIISPKTEESSSTQKNCGSSMGKLNEYRSSLESKPEQVCAPNFLHCKDSQQQTVSVSEQSKTSETCSPGNAASEESQTPNCFVTSLKSPIKQIAWEQKQRGFILDMSNFKPEKVKQRSLSEAISQTKALSQCKNQNVSTPSVFGEGQSGLAVLKELLQKRQQKAQSTNVVQDSTSTHQPDKNISVSNEHKKANKRTRPVTSPRKPRTPRRTKPKEQTPRRLKVDPLNLQTSGHLDNSLSDDSPILFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIDKSELLSHDRQSCSEEKHHVSDSSPWIRASTLNPELFEKVAMDNNENHRHSQWKNSFHPLTSHSNSIMESFCVQQAENCLTEKSRLNRSSVSKEVFLSLPQANSSDWIQGHNRKEADQSLHSANTSFTTILSSPDGELVDAASEDLELYVSRNNDVLTPTPDSSPRSTSSPLQSKNGSFTPRTAHILKPLMSPPSREEIVATLLDHDLSEAIYQEPFCSNPSDVPEKPREIGGRLLMVETRLPNDLIEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRNGQAVVNKESSNSHKMVEDKKIVIMPCKYAPSRQLVQAWLQAKEEYERSKKLPKTELTPVTKSAENVSPSLNPGDTCAVSPQVDKCPHTLSSSAHTKEEVSKSQIALQTSTTGCSQTLLAAASAAVPEEDEDDNDNCYVSYSSPDSPGIPPWQQAASPDFRSLNGDDRHSSPGKELCSLAVENFLKPIKDGIQKSSCSESWEPQVISPIHARARTGKWDPLCLHSTPVMQRKFLEKLPEATGLSPLSVEPKTQKLYNKKGSDADGLRRVLLTTQVENQFAAVNTPKKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLQPDPEFDPICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVTHQDIRSQTPLLIRSGITGLEVTYAADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQMISRVPDDKIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSIQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQIRHDVTVSPNGVAFVKPSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNARQLGLKLIANVTFGYTAANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPRPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKEPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLVEGKASIQDFIFAKEYRGSFSYRPGACVPALELTRKMLAYDRRSEPRVGERVPYVIIYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILPPLARIFSLIGIDVFSWYQELPRIQKATSSSRSELEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQPQHVAIILNQEIRELERKQEQLIKICRNCTGSFDRHIPCVSLNCPVLFKLSRVNRELSKAPYLRQLLDQF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	VRIVTADYYMASPLP EEEEECCEEECCCCC		28576409
12	Phosphorylation	RIVTADYYMASPLPG EEEECCEEECCCCCC		28576409
203	Phosphorylation	GLFKHQLSGNSPAGT CCCCHHHCCCCCCCE		26370283
206	Phosphorylation	KHQLSGNSPAGTLFR CHHHCCCCCCCEEEC		26370283
286	Phosphorylation	SQISQPESQDCRFVP CCCCCCCCCCCCCCC		26745281
408	Phosphorylation	ETPVFMGSSPDESLV CCCCCCCCCCCHHHH		26643407
409	Phosphorylation	TPVFMGSSPDESLVH CCCCCCCCCCHHHHH		26643407
413	Phosphorylation	MGSSPDESLVHLLAG CCCCCCHHHHHHHHH		26643407
449	Phosphorylation	ESQNPQNSDDEENEP CCCCCCCCCCCCCCC		28973931
554	Phosphorylation	VIATSKLSVRPSIFH HHHCCCCCCCCCCCC		22942356
576	Phosphorylation	PPSSAKITFQCKHTS CCCCCEEEEEECCHH		-
600	Phosphorylation	DGLTEDLSQPNSTEK CCCCCCCCCCCCCCC		25338131
604	Phosphorylation	EDLSQPNSTEKGRDN CCCCCCCCCCCCCCC		25338131
612	Phosphorylation	TEKGRDNSVTFTKES CCCCCCCCEEEEECE		27149854
614	Phosphorylation	KGRDNSVTFTKESTY CCCCCCEEEEECEEE		27149854
616	Phosphorylation	RDNSVTFTKESTYSM CCCCEEEEECEEEEE		27149854
619	Phosphorylation	SVTFTKESTYSMKYS CEEEEECEEEEEEEE		27149854
620	Phosphorylation	VTFTKESTYSMKYSG EEEEECEEEEEEEEC		27149854
621	Phosphorylation	TFTKESTYSMKYSGS EEEECEEEEEEEECC		27149854
622	Phosphorylation	FTKESTYSMKYSGSL EEECEEEEEEEECCC		27149854
632	Phosphorylation	YSGSLSSTVHSDNSH EECCCEEEECCCCCH		28576409
648	Phosphorylation	EICKKDKSLPVSSCE HHHHCCCCCCCHHCC		30635358
652	Phosphorylation	KDKSLPVSSCESSVF CCCCCCCHHCCCCCC		30635358
653	Phosphorylation	DKSLPVSSCESSVFD CCCCCCHHCCCCCCC		30635358
656	Phosphorylation	LPVSSCESSVFDYEE CCCHHCCCCCCCCCC		30635358
657	Phosphorylation	PVSSCESSVFDYEED CCHHCCCCCCCCCCC		30635358
661	Phosphorylation	CESSVFDYEEDIPSV CCCCCCCCCCCCCCC		30635358
667	Phosphorylation	DYEEDIPSVTRQVPS CCCCCCCCCCCCCCC		30635358
669	Phosphorylation	EEDIPSVTRQVPSRK CCCCCCCCCCCCCCC		30635358
677	Phosphorylation	RQVPSRKYSNMRKIE CCCCCCCCCCCCCHH		22871156
688	Phosphorylation	RKIEKDASCIHVNRH CCHHCCCCCEEECCC		29895711
697	Phosphorylation	IHVNRHISETILGKN EEECCCCCHHHCCCC		27600695
719	Phosphorylation	NHSKRKLSSEGNEKG CCCCCCCCCCCCCCC		26824392
754	Phosphorylation	PSSGENRSMAHSLES CCCCCCHHHHHHHHH		22871156
761	Phosphorylation	SMAHSLESITDESGL HHHHHHHHCCCCCCH		22871156
822	Phosphorylation	PVTYKLQSGNKPSRL CCEEECCCCCCCCCC		28059163
842	Phosphorylation	KLIGLQETSTKSTET HEECCEECCCCCCCC		21149613
843	Phosphorylation	LIGLQETSTKSTETG EECCEECCCCCCCCC		21149613
844	Phosphorylation	IGLQETSTKSTETGA ECCEECCCCCCCCCC		21149613
1029	Phosphorylation	FWPKVPDSPATKYPI HCCCCCCCCCCCCCC		22817900
1032	Phosphorylation	KVPDSPATKYPIYPL CCCCCCCCCCCCCCC		24759943
1037	Phosphorylation	PATKYPIYPLTPKKS CCCCCCCCCCCCCCC		29109428
1040	Phosphorylation	KYPIYPLTPKKSHRR CCCCCCCCCCCCCCC		26643407
1052	Acetylation	HRRKSKHKSAKKKPG CCCCCCCHHCCCCCC		7719547
1055	Acetylation	KSKHKSAKKKPGKQH CCCCHHCCCCCCCCC		7719557
1074	Phosphorylation	ENIKRTLSFRKKRTH HHHHHHHHHHCCCCC		-
1080	Phosphorylation	LSFRKKRTHAVLSPP HHHHCCCCCEEECCC		25521595
1095	Phosphorylation	SPSYIAETEDCDLSY CHHHEECCCCCCCCH		25521595
1101	Phosphorylation	ETEDCDLSYSDVMSK CCCCCCCCHHHHHHH		25521595
1113	Phosphorylation	MSKLGFLSERSTSPI HHHHCCCCCCCCCCC		22817900
1116	Phosphorylation	LGFLSERSTSPINSS HCCCCCCCCCCCCCC		25619855
1118	Phosphorylation	FLSERSTSPINSSPP CCCCCCCCCCCCCCC		25619855
1122	Phosphorylation	RSTSPINSSPPRCWS CCCCCCCCCCCCCCC		25619855
1123	Phosphorylation	STSPINSSPPRCWSP CCCCCCCCCCCCCCC		25619855
1129	Phosphorylation	SSPPRCWSPTDPRAE CCCCCCCCCCCCCHH		28066266
1131	Phosphorylation	PPRCWSPTDPRAEEI CCCCCCCCCCCHHHH		28066266
1219	Acetylation	QKQRANEKSLSRKHA HHHHHCHHHHHHHCC		19846459
1304	Phosphorylation	SFLESKKSVDLRTFP HHHHCCCCCCCCCCC		22871156
1312	Phosphorylation	VDLRTFPSSRDDSHS CCCCCCCCCCCCCCC		22871156
1342	Phosphorylation	IQRSHNQSAMFTRKE EECCCCCCCCCCCCC		30635358
1346	Phosphorylation	HNQSAMFTRKETTLI CCCCCCCCCCCCHHH		30635358
1459	Phosphorylation	QTPNCFVTSLKSPIK CCCCCEECCCCCHHH		26643407
1460	Phosphorylation	TPNCFVTSLKSPIKQ CCCCEECCCCCHHHH		26643407
1463	Phosphorylation	CFVTSLKSPIKQIAW CEECCCCCHHHHHHH		26643407
1495	Phosphorylation	KVKQRSLSEAISQTK HHHHHCHHHHHHHHH		29514104
1676	Phosphorylation	NLPQKFLSDAVQDLF CCCHHHHHHHHHHHC		25338131
1778	Phosphorylation	KSRLNRSSVSKEVFL CHHCCCCCCCHHHHH		29514104
1831	Phosphorylation	GELVDAASEDLELYV CCCEECCCCCCEEEE		-
1851	Phosphorylation	VLTPTPDSSPRSTSS CCCCCCCCCCCCCCC		-
1852	Phosphorylation	LTPTPDSSPRSTSSP CCCCCCCCCCCCCCC		-
1858	Phosphorylation	SSPRSTSSPLQSKNG CCCCCCCCCCCCCCC		27149854
1964	Phosphorylation	TQNPRPGSPLRNGQA HCCCCCCCCCCCCEE		28973931
2047	Phosphorylation	PGDTCAVSPQVDKCP CCCCCEECCCCCCCC		27841257
2211	Phosphorylation	LPEATGLSPLSVEPK CCCCCCCCCCCCCCC		28066266
2214	Phosphorylation	ATGLSPLSVEPKTQK CCCCCCCCCCCCHHH		28066266
2811	Acetylation	NPRPVKLKFEKVYLP CCCCCCCCEEEEECC		7614275
2814	Acetylation	PVKLKFEKVYLPCVL CCCCCEEEEECCCEE		7340089
3011	Phosphorylation	LPRIQKATSSSRSEL CHHHHHHCCCCHHHH		22871156
3016	Phosphorylation	KATSSSRSELEGRKG HHCCCCHHHHCCCCC		22871156
3110	Phosphorylation	SRVNRELSKAPYLRQ HHHCHHHHHCHHHHH		23737553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REV3L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REV3L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REV3L_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of REV3L_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.