XPF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XPF_MOUSE
• UniProt AC: Q9QZD4
• Protein Name: DNA repair endonuclease XPF
• Gene Name: Ercc4
• Organism: Mus musculus (Mouse).
• Sequence Length: 917
• Subcellular Localization: Nucleus.
• Protein Description: Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link (By similarity)..
• Protein Sequence: MEPGLSGERRSMAPLLEYERQQVLELLDSDGLVVCARGLGTDRLLYHFLRLHCHPACLVLVLNTQPAEEEYFINQLKIEGVEHLPRRVTNEIASNSRYEVYTQGGIIFATSRILVVDFLTGRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPAMLAIQTAILDILNACLKELKCHNPSLEVEDLSLENALGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKVFGQNSGWLFLDASTSMFVNARARVYRVPDVKLNKKAKTSEKTSSPEVQETKKELVLESNPKWEALTDVLKEIEAENKESEALGGPGRVLICASDDRTCCQLRDYLSAGAETFLLRLYRKTFEKDGKAEEVWVNVRKGDGPKRTTKSDKRPKAAPNKERASAKRGAPLKRKKQELTLTQVLGSAEEPPEDKALEEDLCRQTSSSPEGCGVEIKRESFDLNVSSDAAYGILKEPLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPGKPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLARGSAALDAPTDTRKAGGQEQNGTQSSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPELCVERKSVSDLIGSLHSGRLYSQCLAMSRYYRRPVLLIEFDPSKPFSLAPRGAFFQEMSSSDVSSKLTLLTLHFPRLRLLWCPSPHATAELFEELKQNKPQPDAATAMAITADSETLPESDRYNPGPQDFVLKMPGVNAKNCRSLMNQVKNIAELATLSLERLTTILGHSGNAKQLHDFLHTAYADLVSKGRVRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
283	Phosphorylation	QLGAKTKSLVQDLKI HCCCCHHHHHHHHHH	38.72	22817900
289	Acetylation	KSLVQDLKILRTLLQ HHHHHHHHHHHHHHH	48.24	-
357	Phosphorylation	KLNKKAKTSEKTSSP CCCCCCCCCCCCCCH	47.15	30635358
358	Phosphorylation	LNKKAKTSEKTSSPE CCCCCCCCCCCCCHH	36.07	30635358
361	Phosphorylation	KAKTSEKTSSPEVQE CCCCCCCCCCHHHHH	30.31	26745281
362	Phosphorylation	AKTSEKTSSPEVQET CCCCCCCCCHHHHHH	55.77	30635358
363	Phosphorylation	KTSEKTSSPEVQETK CCCCCCCCHHHHHHH	30.25	25266776
369	Phosphorylation	SSPEVQETKKELVLE CCHHHHHHHHHHHHH	30.26	25266776
385	Phosphorylation	NPKWEALTDVLKEIE CHHHHHHHHHHHHHH	30.98	-
501	Phosphorylation	TLTQVLGSAEEPPED EHHHHCCCCCCCCCC	28.48	29899451
519	Phosphorylation	EEDLCRQTSSSPEGC HHHHHHHCCCCCCCC	15.95	23684622
520	Phosphorylation	EDLCRQTSSSPEGCG HHHHHHCCCCCCCCC	22.08	23684622
521	Phosphorylation	DLCRQTSSSPEGCGV HHHHHCCCCCCCCCE	53.98	25521595
522	Phosphorylation	LCRQTSSSPEGCGVE HHHHCCCCCCCCCEE	27.09	25521595
534	Phosphorylation	GVEIKRESFDLNVSS CEEEEHHHEEEECCC	28.26	22817900
614	Phosphorylation	YFLIYGGSTEEQRYL EEEEECCCHHHHHHH	28.43	26239621
615	Phosphorylation	FLIYGGSTEEQRYLT EEEECCCHHHHHHHH	46.98	26239621
620	Phosphorylation	GSTEEQRYLTALRKE CCHHHHHHHHHHHHH	14.22	26239621
622	Phosphorylation	TEEQRYLTALRKEKE HHHHHHHHHHHHHHH	18.08	26239621
736	Phosphorylation	SVSDLIGSLHSGRLY CHHHHHHHHHHHCHH	18.86	27742792
739	Phosphorylation	DLIGSLHSGRLYSQC HHHHHHHHHCHHHHH	30.79	27742792
765	Phosphorylation	LLIEFDPSKPFSLAP EEEEECCCCCCCCCC	55.60	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XPF_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XPF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XPF_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of XPF_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.