PALB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PALB2_MOUSE
• UniProt AC: Q3U0P1
• Protein Name: Partner and localizer of BRCA2
• Gene Name: Palb2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1104
• Subcellular Localization: Nucleus. Colocalizes with BRCA2 in nuclear foci..
• Protein Description: Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (By similarity)..
• Protein Sequence: MEELSGKPLSYAEKEKLKEKLAFLKKEYSRTLARLQRAKRAEKAKNSKKAIEDGVPQPEASSQLSHSESINKGFPCDTLQSNHLDEETGENISQILDVEPQSFNCKQGKEVLHTPRAGDIQGQLLHSTSSPDGKKEQNTLPGTTKTPWEKSSVSQEKEDYFDTNSLALLGKHRKGQESISRKNSRTPVSEKTHLLSLRSQIPDPPALVTGIGEGILIPPSGKSERGIDTLVRGNTVSAEAAVPSCTASNSNHSQHLEHTPPKSGCKITTQGPASSTNLVAQDQKMTIFTVNSVVYKAVRAHGQLPGSPNSCSVNDLTHSNLPANSTPNSKSLKSPSNTVDERNEPLQEDEILGPSKNFNLAAVSPPSTESQIHSCTMLEGLLFPAEYYVRTTRRMSDCQRKIALEAVIQSHLGVKKKELKKKTKATKAVVLSSEDTDQSESGMLDTSTGQSSSGSLSQKLLSPAEVSSPPGPAGKATTPPPGRGHRGKRKSARTSTLGHCQLLFPPCAALAVNRSKGKFTKHKCQNRGVVIHDFELPDEDFGLLKLEKLKSCSEKLIESPDSKNCGERLPREGNHAALEELQRDSETEGLEEELTVPPGEAYRPGPTLRRQPGSKDLSSSIVLFTPADTAAPNDSGRPPPSLCSPAFPILGMTPALGSQAAGETLSTEAAQPCSTSQPPLLGDTNSLVNNSKQCNSSACSPKPDTNLQASGRQGQPACDSDSGPQATPLPVESFTFRENQLCGNACLELHEHSTEQTETADRPACDNLNPGNLQLVSELKNPSSSCSVDVSAMWWERAGAKEPCIVTACEDVVSLWKPLNSLQWEKVHTWHFTEVPVLQIVPVPDVYNLICVALGSLEIREIRALLCSSGDDSEKQVLLKSGDIKAMLGLTKRRLVSSTGTFCNQQIQIMTFADDGSSKDEQLLMPPDETVLTFAEVQGTQEALLGTTTVNSIVIWNLKTGQLLKKMHIDDSYQASVCHGAYSEKGLLFVVVSQPCAKESQALGSPVFQLLVINPKTAQSVGVLLCSLPQGQAGRFLEGDVKDHVAAAVLTSGTIAIWDLLLGHCTALLPPVSDQSWSLVKWSGTDSHLLAGQKDGNIFIYRYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	ELSGKPLSYAEKEKL CCCCCCCCHHHHHHH	30.72	24719451
11	Phosphorylation	LSGKPLSYAEKEKLK CCCCCCCHHHHHHHH	26.85	24719451
127	Phosphorylation	IQGQLLHSTSSPDGK CCCCEEEECCCCCCC	29.92	26643407
128	Phosphorylation	QGQLLHSTSSPDGKK CCCEEEECCCCCCCC	23.60	28066266
129	Phosphorylation	GQLLHSTSSPDGKKE CCEEEECCCCCCCCC	42.77	26643407
130	Phosphorylation	QLLHSTSSPDGKKEQ CEEEECCCCCCCCCC	27.39	28066266
154	Phosphorylation	PWEKSSVSQEKEDYF CCCCCCCCCCCHHHC	34.27	22006019
186	Phosphorylation	ISRKNSRTPVSEKTH CCCCCCCCCCCCCHH	28.06	25266776
274	Phosphorylation	ITTQGPASSTNLVAQ EECCCCCCCCCCEEC	40.61	-
334	Phosphorylation	PNSKSLKSPSNTVDE CCCCCCCCCCCCCCC	38.56	27841257
364	Phosphorylation	NFNLAAVSPPSTESQ CCCEEEECCCCCHHH	26.77	-
432	Phosphorylation	ATKAVVLSSEDTDQS CCEEEEECCCCCCCC	21.77	-
462	Phosphorylation	SLSQKLLSPAEVSSP CHHHHHCCHHHCCCC	32.28	26643407
467	Phosphorylation	LLSPAEVSSPPGPAG HCCHHHCCCCCCCCC	28.74	25266776
468	Phosphorylation	LSPAEVSSPPGPAGK CCHHHCCCCCCCCCC	40.05	25266776
559	Phosphorylation	CSEKLIESPDSKNCG HHHHHHCCCCCCCHH	27.32	26745281
562	Phosphorylation	KLIESPDSKNCGERL HHHCCCCCCCHHCCC	29.20	24719451
700	Phosphorylation	QCNSSACSPKPDTNL CCCCCCCCCCCCCCC	35.36	25266776
783	Phosphorylation	VSELKNPSSSCSVDV HHHHCCCCCCCEEEE	44.25	-
784	Phosphorylation	SELKNPSSSCSVDVS HHHCCCCCCCEEEEH	36.30	-
787	Phosphorylation	KNPSSSCSVDVSAMW CCCCCCCEEEEHHHH	24.25	-
881	Phosphorylation	EKQVLLKSGDIKAML HHEEEEHHCCHHHHH	41.49	22807455
892	Ubiquitination	KAMLGLTKRRLVSST HHHHCCCHHHHHHCC	40.33	22790023
993	Phosphorylation	GLLFVVVSQPCAKES CEEEEEEECCCHHHH	19.45	28285833
1078	Phosphorylation	PVSDQSWSLVKWSGT CCCCCCEEEEEEECC	28.65	22006019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PALB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PALB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PALB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRCA1_HUMAN	BRCA1	physical	25016020
BRCA2_HUMAN	BRCA2	physical	25016020
PALB2_MOUSE	Palb2	physical	25016020
KEAP1_HUMAN	KEAP1	physical	25016020
MO4L1_HUMAN	MORF4L1	physical	25016020
P53_MOUSE	Trp53	genetic	23657012
CDN1A_MOUSE	Cdkn1a	genetic	23657012
TP53B_MOUSE	Trp53bp1	genetic	23657012

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.