dbPTM

PLM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PLM_MOUSE
UniProt AC	Q9Z239
Protein Name	Phospholemman {ECO:0000250\|UniProtKB:P56513}
Gene Name	Fxyd1 {ECO:0000312\|MGI:MGI:1889273}
Organism	Mus musculus (Mouse).
Sequence Length	92
Subcellular Localization	Cell membrane, sarcolemma Single-pass type I membrane protein . Apical cell membrane Single-pass type I membrane protein . Membrane, caveola . Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and inte
Protein Description	Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. [PubMed: 15563542]
Protein Sequence	MASPGHILALCVCLLSMASAEAPQEPDPFTYDYHTLRIGGLTIAGILFILGILIILSKRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSSRRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	S-palmitoylation	LIILSKRCRCKFNQQ HHHHHHHCCCCCCCC	7.42	-
62	Glutathionylation	ILSKRCRCKFNQQQR HHHHHCCCCCCCCCC	7.26	-
62	S-palmitoylation	ILSKRCRCKFNQQQR HHHHHCCCCCCCCCC	7.26	-
70	Phosphorylation	KFNQQQRTGEPDEEE CCCCCCCCCCCCCCC	41.37	24925903
79	Phosphorylation	EPDEEEGTFRSSIRR CCCCCCCCHHHHHHH	21.10	24925903
82	Phosphorylation	EEEGTFRSSIRRLSS CCCCCHHHHHHHHHH	26.40	25521595
83	Phosphorylation	EEGTFRSSIRRLSSR CCCCHHHHHHHHHHC	18.83	25521595
88	Phosphorylation	RSSIRRLSSRRR--- HHHHHHHHHCCC---	21.71	16371442
89	Phosphorylation	SSIRRLSSRRR---- HHHHHHHHCCC----	34.10	16371442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
88	S	Phosphorylation	Kinase	PKCA	P20444	PSP
88	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
83	S	Phosphorylation	17242355
Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3.
88	S	Palmitoylation	-
Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA.
88	S	Phosphorylation	-
Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA.
88	S	Phosphorylation	-
Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PLM_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PLM_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PLM_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-79 AND SER-83, AND MASSSPECTROMETRY.	17242355 [Abstract]