dbPTM

DPOE3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DPOE3_MOUSE
UniProt AC	Q9JKP7
Protein Name	DNA polymerase epsilon subunit 3
Gene Name	Pole3
Organism	Mus musculus (Mouse).
Sequence Length	145
Subcellular Localization	Nucleus .
Protein Description	Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1..
Protein Sequence	MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFITPLKEALEAYRRDEKGKKEASEQKKKDKDKKDSEEQDKSREVEEEDEERLDEDDQNEEEEIDN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAERPEDLN ------CCCCHHHCC	22.85	-
20	Acetylation	AVITRIIKEALPDGV HHHHHHHHHHCCCCC	34.27	19855147
31	Acetylation	PDGVNISKEARSAIS CCCCCCCHHHHHHHH	52.15	7681431
67	Phosphorylation	KRKTLNASDVLSAME CCCCCCHHHHHHHHH	27.46	26643407
71	Phosphorylation	LNASDVLSAMEEMEF CCHHHHHHHHHHHHH	25.97	26643407
83	Phosphorylation	MEFQRFITPLKEALE HHHHHHHHHHHHHHH	21.62	26643407
121	Phosphorylation	DSEEQDKSREVEEED CHHHHHHHHHHHHHH	41.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DPOE3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DPOE3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DPOE3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CHRC1_MOUSE	Chrac1	physical	11000277
H2B2B_MOUSE	Hist2h2bb	physical	11000277

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DPOE3_MOUSE

Related Literatures of Post-Translational Modification