UBP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP1_MOUSE
• UniProt AC: Q8BJQ2
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 1
• Gene Name: Usp1 {ECO:0000312|MGI:MGI:2385198}
• Organism: Mus musculus (Mouse).
• Sequence Length: 784
• Subcellular Localization: Nucleus .
• Protein Description: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity..
• Protein Sequence: MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKTSEYRGSEIDQVVPAAQSSPVSCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKTGVKHLFNIISRKKEALKDDSNQKDKGSCKEESLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGFLQHDAQEVLQCILGNIQETCQLLKKEEIKNLAELSGKVEEQSLQKEETGGITSTEIDSMRNTEDVKEQLPKGNWKRKSDSESSNVKKKVKLSRESQPLEENQRQTRSKRKAIGDTLEAAPKIIPKCVSESESAKPSQKKSKVKINWLKPSTKQPSILSKFCSLGKITTNQRSKGQPKEKEGDVEEDLEKYGSDHTANGGPESPGSSVTPVDSSEAKSGNKGAEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDEGNFVVDQMCELGKPEPLTEEQARGTAGNYDDEVSIRVGGNAQPSKVLNKKNVEGIGLLGGQKSKADYELYNKASNPDKVVGTPFTDNRNSETNDTTNGTHESDRNKESSDQTGVNMNGLENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MPGVIPSESNGLSR -CCCCCCCCCCCCCC	42.40	26643407
9	Phosphorylation	PGVIPSESNGLSRGS CCCCCCCCCCCCCCC	40.30	26643407
13	Phosphorylation	PSESNGLSRGSPSKK CCCCCCCCCCCCCCC	35.67	25266776
16	Phosphorylation	SNGLSRGSPSKKNRL CCCCCCCCCCCCCCC	25.53	25266776
18	Phosphorylation	GLSRGSPSKKNRLSL CCCCCCCCCCCCCCH	58.94	25266776
42	Phosphorylation	RALDFTDSQENEEKT HHCCCCCCCCCHHHH	36.01	29550500
66	Phosphorylation	QVVPAAQSSPVSCEK HHCCHHHCCCCCHHH	31.70	25619855
67	Phosphorylation	VVPAAQSSPVSCEKR HCCHHHCCCCCHHHH	19.76	25521595
70	Phosphorylation	AAQSSPVSCEKRENL HHHCCCCCHHHHCCC	21.68	25619855
127	Phosphorylation	KEALKDDSNQKDKGS HHHHCCCCCCCCCCC	51.82	-
253	Phosphorylation	ITSTEIDSMRNTEDV CCHHHHHHCCCCHHH	25.88	-
310	Phosphorylation	KRKAIGDTLEAAPKI HHHHHHHHHHHHCHH	22.68	25367039
387	Phosphorylation	EDLEKYGSDHTANGG HHHHHHCCCCCCCCC	24.11	25619855
390	Phosphorylation	EKYGSDHTANGGPES HHHCCCCCCCCCCCC	27.15	25619855
397	Phosphorylation	TANGGPESPGSSVTP CCCCCCCCCCCCCCC	37.38	23684622
400	Phosphorylation	GGPESPGSSVTPVDS CCCCCCCCCCCCCCH	25.64	25619855
401	Phosphorylation	GPESPGSSVTPVDSS CCCCCCCCCCCCCHH	35.61	25619855
456	Phosphorylation	REDFQDISVPVQEDE HHHHCCCCCCCCHHH	28.76	25293948
465	Phosphorylation	PVQEDELSKVEESSE CCCHHHHHCHHCCCC	32.38	25293948
470	Phosphorylation	ELSKVEESSEISPEP HHHCHHCCCCCCCCC	21.55	25619855
471	Phosphorylation	LSKVEESSEISPEPK HHCHHCCCCCCCCCC	42.08	25619855
474	Phosphorylation	VEESSEISPEPKTEM HHCCCCCCCCCCHHH	21.11	26824392
528	Phosphorylation	DKMPEVITIHLKCFA HCCCCEEEEEEHHHH	13.91	27180971
687	Ubiquitination	NKASNPDKVVGTPFT HHCCCCCCCCCCCCC	39.82	-
738	Phosphorylation	KISYVVQSLKEYEGK HHHHHHHHHHHHCCE	29.78	27149854
765	Phosphorylation	EEKDFLNSLSPSTSP CCHHHHHHCCCCCCC	32.16	25293948
767	Phosphorylation	KDFLNSLSPSTSPTS HHHHHHCCCCCCCCC	19.34	26745281
769	Phosphorylation	FLNSLSPSTSPTSTP HHHHCCCCCCCCCCC	37.83	26745281
770	Phosphorylation	LNSLSPSTSPTSTPY HHHCCCCCCCCCCCE	41.95	25293948
771	Phosphorylation	NSLSPSTSPTSTPYL HHCCCCCCCCCCCEE	30.44	26745281
773	Phosphorylation	LSPSTSPTSTPYLLF CCCCCCCCCCCEEEE	45.03	25293948
774	Phosphorylation	SPSTSPTSTPYLLFY CCCCCCCCCCEEEEE	30.67	25293948
775	Phosphorylation	PSTSPTSTPYLLFYK CCCCCCCCCEEEEEE	20.59	25293948
777	Phosphorylation	TSPTSTPYLLFYKKL CCCCCCCEEEEEECC	19.00	25293948
781	Phosphorylation	STPYLLFYKKL---- CCCEEEEEECC----	13.74	25168779

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ID2_MOUSE	Id2	physical	24573694

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.