EXO1_MOUSE - dbPTM
EXO1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EXO1_MOUSE
UniProt AC Q9QZ11
Protein Name Exonuclease 1
Gene Name Exo1
Organism Mus musculus (Mouse).
Sequence Length 837
Subcellular Localization Nucleus. Colocalizes with PCNA to discrete nuclear foci in S-phase..
Protein Description 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis..
Protein Sequence MGIQGLLQFIQEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNMLLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARDCFARSINITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNKAGIVQAVITEDSDLLAFGCKKVILKMDQFGNGLEVDQARLGMCKQLGDVFTEEKFRYMCILSGCDYLASLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLRMNITVPEDYITGFIRANNTFLYQLVFDPIQRKLVPLNAYGDDVNPETLTYAGQYVGDSVALQIALGNRDVNTFEQIDDYSPDTMPAHSRSHSWNEKAGQKPPGTNSIWHKNYCPRLEVNSVSHAPQLKEKPSTLGLKQVISTKGLNLPRKSCVLKRPRNEALAEDDLLSQYSSVSKKIKENGCGDGTSPNSSKMSKSCPDSGTAHKTDAHTPSKMRNKFATFLQRRNEESGAVVVPGTRSRFFCSSQDFDNFIPKKESGQPLNETVATGKATTSLLGALDCPDTEGHKPVDANGTHNLSSQIPGNAAVSPEDEAQSSETSKLLGAMSPPSLGTLRSCFSWSGTLREFSRTPSPSASTTLQQFRRKSDPPACLPEASAVVTDRCDSKSEMLGETSQPLHELGCSSRSQESMDSSCGLNTSSLSQPSSRDSGSEESDCNNKSLDNQGEQNSKQHLPHFSKKDGLRRNKVPGLCRSSSMDSFSTTKIKPLVPARVSGLSKKSGSMQTRKHHDVENKPGLQTKISELWKNFGFKKDSEKLPSCKKPLSPVKDNIQLTPETEDEIFNKPECVRAQRAIFH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
463PhosphorylationMSKSCPDSGTAHKTD
CCCCCCCCCCCCCCC		24.16-
465PhosphorylationKSCPDSGTAHKTDAH
CCCCCCCCCCCCCCC		29.55-
473PhosphorylationAHKTDAHTPSKMRNK
CCCCCCCCCHHHHHH		30.8625266776
480AcetylationTPSKMRNKFATFLQR
CCHHHHHHHHHHHHH		26.47-
507PhosphorylationTRSRFFCSSQDFDNF
CCCCEEEECCCCCCC		26.3626643407
508PhosphorylationRSRFFCSSQDFDNFI
CCCEEEECCCCCCCC		34.6426643407
589PhosphorylationSKLLGAMSPPSLGTL
HHHHHCCCCCCHHHH		32.8826745281
592PhosphorylationLGAMSPPSLGTLRSC
HHCCCCCCHHHHHHH		42.7028066266
601PhosphorylationGTLRSCFSWSGTLRE
HHHHHHHCCCCCCHH		25.3522006019
612PhosphorylationTLREFSRTPSPSAST
CCHHHCCCCCCCCCH		27.2425521595
614PhosphorylationREFSRTPSPSASTTL
HHHCCCCCCCCCHHH		30.7622006019
628PhosphorylationLQQFRRKSDPPACLP
HHHHHHHCCCCCCCC		54.2425619855
638PhosphorylationPACLPEASAVVTDRC
CCCCCCCCEEEEECC		21.6725619855
642PhosphorylationPEASAVVTDRCDSKS
CCCCEEEEECCCCCH		15.8925619855
666PhosphorylationLHELGCSSRSQESMD
HHHCCCCCCCHHHHH		39.77-
735PhosphorylationKVPGLCRSSSMDSFS
CCCCCCCCCCCCCCC		26.2626643407
736PhosphorylationVPGLCRSSSMDSFST
CCCCCCCCCCCCCCC		15.4426643407
737PhosphorylationPGLCRSSSMDSFSTT
CCCCCCCCCCCCCCC		28.0525266776
740PhosphorylationCRSSSMDSFSTTKIK
CCCCCCCCCCCCCCC		16.6826643407
742PhosphorylationSSSMDSFSTTKIKPL
CCCCCCCCCCCCCCC		38.8426643407
743PhosphorylationSSMDSFSTTKIKPLV
CCCCCCCCCCCCCCC		30.0526643407
806PhosphorylationPSCKKPLSPVKDNIQ
CCCCCCCCCCCCCCC		35.8525159016
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EXO1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EXO1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EXO1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of EXO1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EXO1_MOUSE

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Related Literatures of Post-Translational Modification

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