RECQ1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RECQ1_MOUSE
• UniProt AC: Q9Z129
• Protein Name: ATP-dependent DNA helicase Q1
• Gene Name: Recql
• Organism: Mus musculus (Mouse).
• Sequence Length: 648
• Subcellular Localization: Nucleus.
• Protein Description: Isoform alpha is a DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Isoform beta may have important roles in the meiotic process. Both isoforms exhibit a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction..
• Protein Sequence: MASVSALTEELESVASELHAIDIQIQELTERRQELLQRKSVLTGKIKQYLEDSSAEASSDLDTSPAAWNKEDFPWFGKVKDVLQNVFKLQKFRPLQLETINVTMARKDIFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSQLKLIYVTPEKIAKSKMFMSRLEKAYEAGRLTGAAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLMGLTATATNHVLKDVQKILCVGKCLTFTASFNRPNLFYEVRQKPSSAEDFTEDIVKLINGRYKGQSGIIYCFSQKDSEQITISLQKLGIHAGTYHANMEPEDKTKVHTQWSANELQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDSRADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNVSKCRRVLIAQHFDEVWNADACNKMCDNCCKDVSFEKKNVTQHCRDLIKILKQAEGLNEKLTPLKLIDAWMGKGAAKLRVAGVVAPALPREDLERIVAHALLQQYLKEDYSFTAYATISYLKVGPRACLLSNEAHAVTMQVKKSAQSSVRGALSEARQVEQVDSKGEEQSSGNSQKSKSRLQPSGSKNAGAKKRKLDDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
190	Phosphorylation	QLKLIYVTPEKIAKS CEEEEEECHHHHHHC	14.57	-
486	Ubiquitination	CKDVSFEKKNVTQHC CCCCCCCHHHHHHHH	47.87	-
514	Acetylation	NEKLTPLKLIDAWMG CCCCCCHHHHHHHCC	44.60	-
522	Acetylation	LIDAWMGKGAAKLRV HHHHHCCCCCHHHHC	29.30	-
580	Phosphorylation	GPRACLLSNEAHAVT CCCEEHHCCCCEEEE	21.48	-
597	Phosphorylation	VKKSAQSSVRGALSE HHHHHHHHHHHHHHH	12.07	-
620	Phosphorylation	SKGEEQSSGNSQKSK CCCCCCCCCCCCCHH	41.51	28285833
623	Phosphorylation	EEQSSGNSQKSKSRL CCCCCCCCCCHHHCC	42.37	23684622
633	Phosphorylation	SKSRLQPSGSKNAGA HHHCCCCCCCCCCCC	42.62	-
635	Phosphorylation	SRLQPSGSKNAGAKK HCCCCCCCCCCCCCC	27.37	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RECQ1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RECQ1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RECQ1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RECQ1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.