SAE1_MOUSE - dbPTM
SAE1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAE1_MOUSE
UniProt AC Q9R1T2
Protein Name SUMO-activating enzyme subunit 1
Gene Name Sae1
Organism Mus musculus (Mouse).
Sequence Length 350
Subcellular Localization Nucleus.
Protein Description The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity)..
Protein Sequence MVEKEEAGGGGGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDPGAQFLIQTGSVGRNRAEASLERAQNLNPMVDVKVDTEDVEKKPESFFTKFDAVCLTCCSRDVIIKVDQICHRNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPEAKRAKLDSSETTMVKKKVLFCPVKEALEVDWSGEKAKAALKRTAPDYFLLQVLLKFRTDKGRDPTSESYKEDAELLLQIRNDVFDSLGISPDLLPDDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGSGIVECLGPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MVEKEEAG
-------CCCCCCCC		8.73-
2Acetylation------MVEKEEAGG
------CCCCCCCCC		16.88-
16PhosphorylationGGGGGGISEEEAAQY
CCCCCCCCHHHHHHH		42.0826239621
36AcetylationLWGLEAQKRLRASRV
HHCHHHHHHHHHCEE		61.5222826441
36UbiquitinationLWGLEAQKRLRASRV
HHCHHHHHHHHHCEE		61.5222790023
145AcetylationCSRDVIIKVDQICHR
CCCCEEEEHHHHHHC		28.7422826441
154PhosphorylationDQICHRNSIKFFTGD
HHHHHCCCCEEEECC		27.4129514104
187UbiquitinationEEKTKVAKVSQGVED
HCHHHEEEHHHCCCC		45.4622790023
189PhosphorylationKTKVAKVSQGVEDGP
HHHEEEHHHCCCCCH		22.1026824392
199AcetylationVEDGPEAKRAKLDSS
CCCCHHHHHHCCCCC		51.7569581
199UbiquitinationVEDGPEAKRAKLDSS
CCCCHHHHHHCCCCC		51.7522790023
202AcetylationGPEAKRAKLDSSETT
CHHHHHHCCCCCCCC		57.7823806337
202UbiquitinationGPEAKRAKLDSSETT
CHHHHHHCCCCCCCC		57.78-
206PhosphorylationKRAKLDSSETTMVKK
HHHCCCCCCCCCCEE		38.3329176673
208PhosphorylationAKLDSSETTMVKKKV
HCCCCCCCCCCEEEE		23.3429176673
209PhosphorylationKLDSSETTMVKKKVL
CCCCCCCCCCEEEEE		18.8629176673
212UbiquitinationSSETTMVKKKVLFCP
CCCCCCCEEEEEEEE		35.7322790023
232UbiquitinationEVDWSGEKAKAALKR
ECCCCHHHHHHHHHH		59.7322790023
283PhosphorylationIRNDVFDSLGISPDL
HHHHHHHHCCCCCCC		19.6125293948
287PhosphorylationVFDSLGISPDLLPDD
HHHHCCCCCCCCCHH		15.5721189417
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAE1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAE1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAE1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SAE1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAE1_MOUSE

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Related Literatures of Post-Translational Modification

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