1433E_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1433E_RAT
• UniProt AC: P62260
• Protein Name: 14-3-3 protein epsilon
• Gene Name: Ywhae
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 255
• Subcellular Localization: Nucleus . Cytoplasm . Melanosome .
• Protein Description: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm..
• Protein Sequence: MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDDREDLV -------CCHHHHHH	12.49	-
12	Acetylation	EDLVYQAKLAEQAER HHHHHHHHHHHHHHH	32.48	22902405
12	Ubiquitination	EDLVYQAKLAEQAER HHHHHHHHHHHHHHH	32.48	-
28	Acetylation	DEMVESMKKVAGMDV HHHHHHHHHHCCCCE	54.07	22902405
46	Phosphorylation	VEERNLLSVAYKNVI HHHHHHHHHHHHHHH	14.10	27097102
49	Phosphorylation	RNLLSVAYKNVIGAR HHHHHHHHHHHHHHH	10.84	23984901
50	Acetylation	NLLSVAYKNVIGARR HHHHHHHHHHHHHHH	34.69	25786129
50	Ubiquitination	NLLSVAYKNVIGARR HHHHHHHHHHHHHHH	34.69	-
64	Phosphorylation	RASWRIISSIEQKEE HHHHHHHHHHHHHHH	23.92	22673903
65	Phosphorylation	ASWRIISSIEQKEEN HHHHHHHHHHHHHHC	21.53	22673903
69	Acetylation	IISSIEQKEENKGGE HHHHHHHHHHCCCCH	54.96	22902405
69	Ubiquitination	IISSIEQKEENKGGE HHHHHHHHHHCCCCH	54.96	-
73	Acetylation	IEQKEENKGGEDKLK HHHHHHCCCCHHHHH	72.13	22902405
78	Acetylation	ENKGGEDKLKMIREY HCCCCHHHHHHHHHH	45.78	22902405
106	Ubiquitination	DILDVLDKHLIPAAN HHHHHHHHHCCCCCC	35.83	-
118	Acetylation	AANTGESKVFYYKMK CCCCCCCEEEEEEEC	31.87	22902405
118	Ubiquitination	AANTGESKVFYYKMK CCCCCCCEEEEEEEC	31.87	-
123	Acetylation	ESKVFYYKMKGDYHR CCEEEEEEECCCHHH	23.82	22902405
125	Ubiquitination	KVFYYKMKGDYHRYL EEEEEEECCCHHHHH	44.47	-
125	Acetylation	KVFYYKMKGDYHRYL EEEEEEECCCHHHHH	44.47	22902405
131	Phosphorylation	MKGDYHRYLAEFATG ECCCHHHHHHHHHCC	9.28	27097102
137	Phosphorylation	RYLAEFATGNDRKEA HHHHHHHCCCCHHHH	41.67	22673903
142	Acetylation	FATGNDRKEAAENSL HHCCCCHHHHHHHHH	55.35	22902405
142	Ubiquitination	FATGNDRKEAAENSL HHCCCCHHHHHHHHH	55.35	-
153	Acetylation	ENSLVAYKAASDIAM HHHHHHHHHHCHHCC	27.95	26302492
187	Phosphorylation	FYYEILNSPDRACRL HHHHHHCCHHHHHHH	25.40	30240740
192	S-nitrosocysteine	LNSPDRACRLAKAAF HCCHHHHHHHHHHHH	3.69	-
192	S-nitrosylation	LNSPDRACRLAKAAF HCCHHHHHHHHHHHH	3.69	17629318
208	Phosphorylation	DAIAELDTLSEESYK HHHHHHHCCCHHHCC	44.82	25403869
210	Phosphorylation	IAELDTLSEESYKDS HHHHHCCCHHHCCCH	41.22	23712012
213	Phosphorylation	LDTLSEESYKDSTLI HHCCCHHHCCCHHHH	33.17	8121835
214	Phosphorylation	DTLSEESYKDSTLIM HCCCHHHCCCHHHHH	23.30	23984901
215	Acetylation	TLSEESYKDSTLIMQ CCCHHHCCCHHHHHH	55.25	25786129
217	Phosphorylation	SEESYKDSTLIMQLL CHHHCCCHHHHHHHH	22.44	23984901
218	Phosphorylation	EESYKDSTLIMQLLR HHHCCCHHHHHHHHH	30.36	23984901
229	Phosphorylation	QLLRDNLTLWTSDMQ HHHHCCCEEEECCCC	26.89	28551015
232	Phosphorylation	RDNLTLWTSDMQGDG HCCCEEEECCCCCCC	20.26	28432305
233	Phosphorylation	DNLTLWTSDMQGDGE CCCEEEECCCCCCCH	21.36	27097102
244	Ubiquitination	GDGEEQNKEALQDVE CCCHHHHHHHHHHCH	44.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 1433E_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1433E_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1433E_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of 1433E_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.