MYSM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYSM1_MOUSE
• UniProt AC: Q69Z66
• Protein Name: Histone H2A deubiquitinase MYSM1
• Gene Name: Mysm1
• Organism: Mus musculus (Mouse).
• Sequence Length: 819
• Subcellular Localization: Nucleus .
• Protein Description: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity)..
• Protein Sequence: MEAEEADVDVEGDVAAAAQPGNDESTASVFQDHYLDSTWRRENGCLPWTLDSTISDENRAIIEKMLLEEEYYLSNKSLPGKFWVNQKEDNKKYTNSLQKSSKAMVDSPAKPASHSVKWTVEEKELFEQGLAKFGRRWTKIATLLKSRTVLQVKSYARQYFKNKVKWDVEKETPTQKSSSDLQVKNKDDRTKAWAAACLRGSADPCLNAVKIEKLSDDEDVDITDELDELTSQTSQNSGSHLTLDVPNSKMYTTNQGELCQEGPLAKSSGESLQNVKQGEGEACSSSEIASWAEKQKSTDKNSAELNEKYNKVVEEHTLHRGEVREEAKHSPSPEPCERQDSSGNEMLLPPCQIEEENHEGEELKPPEQEVEIDRNVIQEEEKQAIPEFFEGRQTKTPERYLKIRNYILDQWEICKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFGCEQAVYNRPQPLDKVRAADRKDAEAAYQLAWRLQSMRTRRRRVRDPWGNWCDAKDLEGQTFEHLSVEEMARRKEEEKCKPIKFSKASKLPKSSLDPFQLIPCNFFSEEKQEPFQVKVAAEALLIMNLHAHVSMAEVIGLLGGRYSEADKVLEVCAAEPCNSLSTGLQCEMDPVSQTQASETLALRGYSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAKFIGMIVSPYNRSNPLPYSQITCLVISEEVSPDGTYRLPYKFEVQQMLEEPQWELVFEKTRWIIEKYRLSNSSVPMDRIFRRDSDLTCLQKLLECLRKTLSKVANCFIAEEFLTQIENLFLSNYKSKEENGLAEEDSTKELFM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	LPWTLDSTISDENRA CCCCCCCCCCHHHHH	24.94	25266776
76	Ubiquitination	EEYYLSNKSLPGKFW HHHHHCCCCCCCCCC	50.41	22790023
107	Phosphorylation	SSKAMVDSPAKPASH HHHHHCCCCCCCCCC	18.49	29514104
117	Acetylation	KPASHSVKWTVEEKE CCCCCCCCEEECHHH	39.91	19857875
215	Phosphorylation	AVKIEKLSDDEDVDI CEEEECCCCCCCCCC	54.83	25619855
223	Phosphorylation	DDEDVDITDELDELT CCCCCCCHHHHHHHH	20.96	25619855
230	Phosphorylation	TDELDELTSQTSQNS HHHHHHHHHCCCCCC	19.42	25293948
231	Phosphorylation	DELDELTSQTSQNSG HHHHHHHHCCCCCCC	44.05	25293948
233	Phosphorylation	LDELTSQTSQNSGSH HHHHHHCCCCCCCCC	31.86	25293948
234	Phosphorylation	DELTSQTSQNSGSHL HHHHHCCCCCCCCCE	21.52	25293948
237	Phosphorylation	TSQTSQNSGSHLTLD HHCCCCCCCCCEEEE	33.75	25293948
239	Phosphorylation	QTSQNSGSHLTLDVP CCCCCCCCCEEEECC	18.36	25293948
242	Phosphorylation	QNSGSHLTLDVPNSK CCCCCCEEEECCCCC	18.58	25293948
248	Phosphorylation	LTLDVPNSKMYTTNQ EEEECCCCCEEECCC	16.84	25293948
330	Phosphorylation	VREEAKHSPSPEPCE HHHHHCCCCCCCCCC	26.77	25521595
332	Phosphorylation	EEAKHSPSPEPCERQ HHHCCCCCCCCCCCC	44.93	25521595
666	Ubiquitination	RDIDTQAKYQSYFSR HHCCHHHHHHHHHCC	33.72	22790023
671	Ubiquitination	QAKYQSYFSRGGAKF HHHHHHHHCCCCCCE	4.93	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYSM1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYSM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYSM1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFE2_MOUSE	Tcf3	physical	22169041
SMCA2_MOUSE	Smarca2	physical	22169041
SMCA4_MOUSE	Smarca4	physical	22169041
TRAF3_MOUSE	Traf3	physical	26474655
TRAF6_MOUSE	Traf6	physical	26474655
UBC_MOUSE	Ubc	physical	26474655
KAT2B_MOUSE	Kat2b	physical	26474655
H2A2A_MOUSE	Hist2h2aa1	physical	26474655

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.