ASPP1_MOUSE - dbPTM
ASPP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASPP1_MOUSE
UniProt AC Q62415
Protein Name Apoptosis-stimulating of p53 protein 1
Gene Name Ppp1r13b
Organism Mus musculus (Mouse).
Sequence Length 1087
Subcellular Localization Cytoplasm. Nucleus. Predominantly cytoplasmic (By similarity). Some fraction is nuclear..
Protein Description Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity)..
Protein Sequence MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGGCHLAEVWRGSERPIPYDHMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGARQTQEQRTQRSVVNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSVSENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSYNGRLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSTGGFPLPGDPVKPQSLTIASSAAHGRSKSANDGNWPPLKQNSASVKSTQMTGDWKDSGMEGTLKQGAISSQPLPLSALGATEKLGIEIGKGPPPIPGVGKPLPPSYGTYPSSGPLGPGSTSSLERRKEGSLPRPGAGPPSRQKPAPLPPASNAPQPGSSQQIQQRISVPPSPTYPPAGPPAFPTGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPPAHGTLNKSVKAVYGKPVLPSGSASPSPLPFLHGSLGTGTAQPQPPSDSAEKEPEQEGPSVPGEGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFVGTLADMDNGNTNANGNLDEPFPPRPTAPLPEELAPSSDANDNELPSPEPEELICPQTTHQTAEPTEDNNNNVAPVPSTEQIPSPVAEAPSEEDQVPPAPLSPVIHPPAASASKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGTVYALWDYEAQNSDELSFHEGDAITILRRKDENETEWWWARLGDREGYVPKNLLGLYPRIKPRQRTLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
85PhosphorylationFFLRHEDSPTESSEQ
EEEECCCCCCCCHHH		30.6429899451
87PhosphorylationLRHEDSPTESSEQGA
EECCCCCCCCHHHHH		53.0729899451
102PhosphorylationRQTQEQRTQRSVVNV
HHHHHHHHHHCCCCC		28.2022802335
211PhosphorylationKIMNGNLSAEIERFS
HHHCCCCHHHHHHHH		28.0527180971
230PhosphorylationEKKQEVQTAILRVDQ
HHHHHHHHHHHHHHH		22.3520047950
239PhosphorylationILRVDQLSQQLEDLK
HHHHHHHHHHHHHHH		15.3920047950
288UbiquitinationLNQEQNSKLQQQKEL
CCHHHHHHHHHHHHH		58.8422790023
311PhosphorylationAMMDKRISELRERLY
HHHHHHHHHHHHHHH		34.3125777480
330PhosphorylationQLNRVNGTSSPQSPL
EEECCCCCCCCCCCC		22.3425777480
331PhosphorylationLNRVNGTSSPQSPLS
EECCCCCCCCCCCCC		41.2326745281
332PhosphorylationNRVNGTSSPQSPLST
ECCCCCCCCCCCCCC		27.1425521595
335PhosphorylationNGTSSPQSPLSTSGR
CCCCCCCCCCCCCCC		31.0625521595
338PhosphorylationSSPQSPLSTSGRVAA
CCCCCCCCCCCCEEE		24.7425777480
339PhosphorylationSPQSPLSTSGRVAAV
CCCCCCCCCCCEEEE		42.7725777480
340PhosphorylationPQSPLSTSGRVAAVG
CCCCCCCCCCEEEEC		22.6425777480
349PhosphorylationRVAAVGPYIQVPSTG
CEEEECCEEECCCCC		9.6929514104
374PhosphorylationPQSLTIASSAAHGRS
CCCEEEECHHHCCCC		19.3625168779
375PhosphorylationQSLTIASSAAHGRSK
CCEEEECHHHCCCCC		22.0625168779
398PhosphorylationPLKQNSASVKSTQMT
CCCCCCCCCEEEECC		29.8728059163
401PhosphorylationQNSASVKSTQMTGDW
CCCCCCEEEECCCCC		23.0128059163
459PhosphorylationVGKPLPPSYGTYPSS
CCCCCCCCCCCCCCC		33.9725777480
460PhosphorylationGKPLPPSYGTYPSSG
CCCCCCCCCCCCCCC		21.1825777480
462PhosphorylationPLPPSYGTYPSSGPL
CCCCCCCCCCCCCCC		24.8325777480
463PhosphorylationLPPSYGTYPSSGPLG
CCCCCCCCCCCCCCC		9.2125777480
465PhosphorylationPSYGTYPSSGPLGPG
CCCCCCCCCCCCCCC		37.2025777480
466PhosphorylationSYGTYPSSGPLGPGS
CCCCCCCCCCCCCCC		39.6725777480
473PhosphorylationSGPLGPGSTSSLERR
CCCCCCCCCHHHHHH		28.4027180971
474PhosphorylationGPLGPGSTSSLERRK
CCCCCCCCHHHHHHH		28.4026239621
475PhosphorylationPLGPGSTSSLERRKE
CCCCCCCHHHHHHHC		34.3226239621
476PhosphorylationLGPGSTSSLERRKEG
CCCCCCHHHHHHHCC		34.0526239621
484PhosphorylationLERRKEGSLPRPGAG
HHHHHCCCCCCCCCC		35.9729514104
521PhosphorylationQQIQQRISVPPSPTY
HHHHHHHCCCCCCCC		30.6626060331
525PhosphorylationQRISVPPSPTYPPAG
HHHCCCCCCCCCCCC		24.6526060331
527PhosphorylationISVPPSPTYPPAGPP
HCCCCCCCCCCCCCC		53.6626060331
528PhosphorylationSVPPSPTYPPAGPPA
CCCCCCCCCCCCCCC		15.5926060331
552MethylationLPLTVAIRPFLADKG
CCEEEEEHHHHCCCC		13.2324129315
552Asymmetric dimethylarginineLPLTVAIRPFLADKG
CCEEEEEHHHHCCCC		13.23-
564PhosphorylationDKGSRPQSPRKGPQT
CCCCCCCCCCCCCCC		29.3829899451
586PhosphorylationSMYLQQATPPKNYQP
HHHHHCCCCCCCCCC		35.4726643407
653PhosphorylationEPEQEGPSVPGEGST
CHHHCCCCCCCCCCC		52.3728285833
659PhosphorylationPSVPGEGSTVESLPR
CCCCCCCCCCCCCCC		25.6125521595
660PhosphorylationSVPGEGSTVESLPRP
CCCCCCCCCCCCCCC		38.8724925903
663PhosphorylationGEGSTVESLPRPLSP
CCCCCCCCCCCCCCC		39.0624925903
669PhosphorylationESLPRPLSPTKLTPI
CCCCCCCCCCCCCCC		32.9525521595
671PhosphorylationLPRPLSPTKLTPIVH
CCCCCCCCCCCCCCC		35.0025521595
679PhosphorylationKLTPIVHSPLRYQSD
CCCCCCCCCCCCCCH		18.0928066266
683PhosphorylationIVHSPLRYQSDADLE
CCCCCCCCCCHHHHH		21.7629472430
685PhosphorylationHSPLRYQSDADLEAL
CCCCCCCCHHHHHHH		26.3229472430
707PhosphorylationPRPLKKRSSITEPEG
CCCCCCCCCCCCCCC		34.6625521595
708PhosphorylationRPLKKRSSITEPEGP
CCCCCCCCCCCCCCC		37.2525521595
710PhosphorylationLKKRSSITEPEGPGG
CCCCCCCCCCCCCCC		47.6525521595
1049UbiquitinationAITILRRKDENETEW
EEEEEECCCCCCCCE		64.0622790023
1070UbiquitinationDREGYVPKNLLGLYP
CCCCCCCHHHHHCCC		50.6222790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASPP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASPP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASPP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRAF3_MOUSETraf3physical
25072696
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASPP1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332 AND SER-335, ANDMASS SPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-669, AND MASSSPECTROMETRY.

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