I17RA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: I17RA_MOUSE
• UniProt AC: Q60943
• Protein Name: Interleukin-17 receptor A
• Gene Name: Il17ra
• Organism: Mus musculus (Mouse).
• Sequence Length: 864
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor for IL17A. [PubMed: 17911633]
• Protein Sequence: MAIRRCWPRVVPGPALGWLLLLLNVLAPGRASPRLLDFPAPVCAQEGLSCRVKNSTCLDDSWIHPKNLTPSSPKNIYINLSVSSTQHGELVPVLHVEWTLQTDASILYLEGAELSVLQLNTNERLCVKFQFLSMLQHHRKRWRFSFSHFVVDPGQEYEVTVHHLPKPIPDGDPNHKSKIIFVPDCEDSKMKMTTSCVSSGSLWDPNITVETLDTQHLRVDFTLWNESTPYQVLLESFSDSENHSCFDVVKQIFAPRQEEFHQRANVTFTLSKFHWCCHHHVQVQPFFSSCLNDCLRHAVTVPCPVISNTTVPKPVADYIPLWVYGLITLIAILLVGSVIVLIICMTWRLSGADQEKHGDDSKINGILPVADLTPPPLRPRKVWIVYSADHPLYVEVVLKFAQFLITACGTEVALDLLEEQVISEVGVMTWVSRQKQEMVESNSKIIILCSRGTQAKWKAILGWAEPAVQLRCDHWKPAGDLFTAAMNMILPDFKRPACFGTYVVCYFSGICSERDVPDLFNITSRYPLMDRFEEVYFRIQDLEMFEPGRMHHVRELTGDNYLQSPSGRQLKEAVLRFQEWQTQCPDWFERENLCLADGQDLPSLDEEVFEDPLLPPGGGIVKQQPLVRELPSDGCLVVDVCVSEEESRMAKLDPQLWPQRELVAHTLQSMVLPAEQVPAAHVVEPLHLPDGSGAAAQLPMTEDSEACPLLGVQRNSILCLPVDSDDLPLCSTPMMSPDHLQGDAREQLESLMLSVLQQSLSGQPLESWPRPEVVLEGCTPSEEEQRQSVQSDQGYISRSSPQPPEWLTEEEELELGEPVESLSPEELRSLRKLQRQLFFWELEKNPGWNSLEPRRPTPEEQNPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	N-linked_Glycosylation	GLSCRVKNSTCLDDS CCCCEECCCCCCCCC	39.43	-
79	N-linked_Glycosylation	SPKNIYINLSVSSTQ CCCEEEEEEEEECCC	14.86	-
206	N-linked_Glycosylation	SGSLWDPNITVETLD CCCCCCCCEEEEECC	39.84	-
225	N-linked_Glycosylation	RVDFTLWNESTPYQV EEEEEEECCCCCHHH	36.13	-
242	N-linked_Glycosylation	ESFSDSENHSCFDVV HHCCCCCCCCHHHHH	36.00	-
265	N-linked_Glycosylation	EEFHQRANVTFTLSK HHHHHHHCEEEEEEH	35.23	-
308	N-linked_Glycosylation	VPCPVISNTTVPKPV CCCCCCCCCCCCCCH	28.75	-
373	Phosphorylation	ILPVADLTPPPLRPR EEEHHHCCCCCCCCC	34.01	22817900
603	Phosphorylation	ADGQDLPSLDEEVFE CCCCCCCCCCHHHHC	56.61	23649490
732	Phosphorylation	DDLPLCSTPMMSPDH CCCCCCCCCCCCCCC	17.76	22807455
736	Phosphorylation	LCSTPMMSPDHLQGD CCCCCCCCCCCCCCC	22.41	22817900
779	Phosphorylation	EVVLEGCTPSEEEQR CEEEECCCCCHHHHH	40.48	-
799	Phosphorylation	DQGYISRSSPQPPEW CCCCCCCCCCCCCCC	39.31	28494245
800	Phosphorylation	QGYISRSSPQPPEWL CCCCCCCCCCCCCCC	26.83	25195567
850	Phosphorylation	EKNPGWNSLEPRRPT CCCCCCCCCCCCCCC	27.83	28066266
857	Phosphorylation	SLEPRRPTPEEQNPS CCCCCCCCHHHHCCC	41.33	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
779	T	Phosphorylation	Kinase	GSK3A	P49840	PSP
779	T	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of I17RA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of I17RA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF6_MOUSE	Traf6	physical	10748240
TNAP3_HUMAN	TNFAIP3	physical	23737552

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.