dbPTM

RTN4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RTN4_MOUSE
UniProt AC	Q99P72
Protein Name	Reticulon-4
Gene Name	Rtn4
Organism	Mus musculus (Mouse).
Sequence Length	1162
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. Localizes throughout the ER tubular network. Co-localizes with TMEM33 at the ER sheets.
Protein Description	Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules. Regulates membrane morphogenesis in the ER by promoting tubular ER production. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (By similarity)..
Protein Sequence	MEDIDQSSLVSSSADSPPRPPPAFKYQFVTEPEDEEDEEDEEEEEDDEDLEELEVLERKPAAGLSAAPVPPAAAPLLDFSSDSVPPAPRGPLPAAPPTAPERQPSWERSPAASAPSLPPAAAVLPSKLPEDDEPPARPPAPAGASPLAEPAAPPSTPAAPKRRGSGSVDETLFALPAASEPVIPSSAEKIMDLKEQPGNTVSSGQEDFPSVLFETAASLPSLSPLSTVSFKEHGYLGNLSAVASTEGTIEETLNEASRELPERATNPFVNRESAEFSVLEYSEMGSSFNGSPKGESAMLVENTKEEVIVRSKDKEDLVCSAALHNPQESPATLTKVVKEDGVMSPEKTMDIFNEMKMSVVAPVREEYADFKPFEQAWEVKDTYEGSRDVLAARANMESKVDKKCFEDSLEQKGHGKDSESRNENASFPRTPELVKDGSRAYITCDSFSSATESTAANIFPVLEDHTSENKTDEKKIEERKAQIITEKTSPKTSNPFLVAIHDSEADYVTTDNLSKVTEAVVATMPEGLTPDLVQEACESELNEATGTKIAYETKVDLVQTSEAIQESIYPTAQLCPSFEEAEATPSPVLPDIVMEAPLNSLLPSTGASVAQPSASPLEVPSPVSYDGIKLEPENPPPYEEAMSVALKTSDSKEEIKEPESFNAAAQEAEAPYISIACDLIKETKLSTEPSPEFSNYSEIAKFEKSVPDHCELVDDSSPESEPVDLFSDDSIPEVPQTQEEAVMLMKESLTEVSETVTQHKHKERLSASPQEVGKPYLESFQPNLHITKDAASNEIPTLTKKETISLQMEEFNTAIYSNDDLLSSKEDKMKESETFSDSSPIEIIDEFPTFVSAKDDSPKEYTDLEVSNKSEIANVQSGANSLPCSELPCDLSFKNTYPKDEAHVSDEFSKSRSSVSKVPLLLPNVSALESQIEMGNIVKPKVLTKEAEEKLPSDTEKEDRSLTAVLSAELNKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNSTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSIPVIYERHQAQIDHYLGLANKSVKDAMAKIQAKIPGLKRKAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDIDQSS -------CCCCCHHH	44.66	17242355
7	Phosphorylation	-MEDIDQSSLVSSSA -CCCCCHHHCCCCCC	23.15	25619855
8	Phosphorylation	MEDIDQSSLVSSSAD CCCCCHHHCCCCCCC	27.45	25619855
11	Phosphorylation	IDQSSLVSSSADSPP CCHHHCCCCCCCCCC	24.70	25619855
12	Phosphorylation	DQSSLVSSSADSPPR CHHHCCCCCCCCCCC	23.28	27742792
13	Phosphorylation	QSSLVSSSADSPPRP HHHCCCCCCCCCCCC	28.70	26824392
16	Phosphorylation	LVSSSADSPPRPPPA CCCCCCCCCCCCCCC	36.20	26824392
30	Phosphorylation	AFKYQFVTEPEDEED CCEEEEECCCCCCCC	47.30	27180971
49 (in isoform 3)	Phosphorylation	-	67.39	25521595
80	Phosphorylation	AAPLLDFSSDSVPPA CCCCCCCCCCCCCCC	32.66	30635358
81	Phosphorylation	APLLDFSSDSVPPAP CCCCCCCCCCCCCCC	33.62	30635358
83	Phosphorylation	LLDFSSDSVPPAPRG CCCCCCCCCCCCCCC	38.17	30635358
98	Phosphorylation	PLPAAPPTAPERQPS CCCCCCCCCCCCCCC	54.51	24925903
105	Phosphorylation	TAPERQPSWERSPAA CCCCCCCCCCCCCCC	32.98	24925903
109	Phosphorylation	RQPSWERSPAASAPS CCCCCCCCCCCCCCC	13.84	27087446
113	Phosphorylation	WERSPAASAPSLPPA CCCCCCCCCCCCCCH	42.70	22942356
116	Phosphorylation	SPAASAPSLPPAAAV CCCCCCCCCCCHHHC	53.90	25159016
126	Phosphorylation	PAAAVLPSKLPEDDE CHHHCCCCCCCCCCC	42.54	25159016
145	Phosphorylation	PPAPAGASPLAEPAA CCCCCCCCCCCCCCC	21.38	25521595
155	Phosphorylation	AEPAAPPSTPAAPKR CCCCCCCCCCCCCCC	46.06	25619855
156	Phosphorylation	EPAAPPSTPAAPKRR CCCCCCCCCCCCCCC	23.79	26824392
156	Phosphorylation	EPAAPPSTPAAPKRR CCCCCCCCCCCCCCC	23.79	26824392
165	Phosphorylation	AAPKRRGSGSVDETL CCCCCCCCCCCCHHH	26.53	26824392
165	Phosphorylation	AAPKRRGSGSVDETL CCCCCCCCCCCCHHH	26.53	27180971
165	Phosphorylation	AAPKRRGSGSVDETL CCCCCCCCCCCCHHH	26.53	24925903
167	Phosphorylation	PKRRGSGSVDETLFA CCCCCCCCCCHHHCC	28.26	26239621
167	Phosphorylation	PKRRGSGSVDETLFA CCCCCCCCCCHHHCC	28.26	26239621
167	Phosphorylation	PKRRGSGSVDETLFA CCCCCCCCCCHHHCC	28.26	24925903
171	Phosphorylation	GSGSVDETLFALPAA CCCCCCHHHCCCCCC	23.78	26239621
171	Phosphorylation	GSGSVDETLFALPAA CCCCCCHHHCCCCCC	23.78	24925903
179	Phosphorylation	LFALPAASEPVIPSS HCCCCCCCCCCCCCC	44.53	26239621
179	Phosphorylation	LFALPAASEPVIPSS HCCCCCCCCCCCCCC	44.53	24925903
185	Phosphorylation	ASEPVIPSSAEKIMD CCCCCCCCCHHHHHC	30.93	25777480
185	Phosphorylation	ASEPVIPSSAEKIMD CCCCCCCCCHHHHHC	30.93	24925903
186	Phosphorylation	SEPVIPSSAEKIMDL CCCCCCCCHHHHHCC	34.78	25777480
186	Phosphorylation	SEPVIPSSAEKIMDL CCCCCCCCHHHHHCC	34.78	24925903
190	Ubiquitination	IPSSAEKIMDLKEQP CCCCHHHHHCCCCCC	1.63	27667366
193	Phosphorylation	SAEKIMDLKEQPGNT CHHHHHCCCCCCCCC	3.49	25777480
210	Phosphorylation	SGQEDFPSVLFETAA CCCCCCCHHHHHCCC	31.29	26745281
215	Phosphorylation	FPSVLFETAASLPSL CCHHHHHCCCCCCCC	21.86	26745281
218	Phosphorylation	VLFETAASLPSLSPL HHHHCCCCCCCCCCC	38.05	26745281
221	Phosphorylation	ETAASLPSLSPLSTV HCCCCCCCCCCCCCC	46.93	26745281
223	Phosphorylation	AASLPSLSPLSTVSF CCCCCCCCCCCCCEE	28.29	24453211
226	Phosphorylation	LPSLSPLSTVSFKEH CCCCCCCCCCEECCC	30.10	23649490
227	Phosphorylation	PSLSPLSTVSFKEHG CCCCCCCCCEECCCC	28.05	26745281
229	Phosphorylation	LSPLSTVSFKEHGYL CCCCCCCEECCCCCC	30.59	26745281
235	Phosphorylation	VSFKEHGYLGNLSAV CEECCCCCCCCHHHH	17.22	30635358
240	Phosphorylation	HGYLGNLSAVASTEG CCCCCCHHHHCCCCC	25.38	30635358
244	Phosphorylation	GNLSAVASTEGTIEE CCHHHHCCCCCCHHH	22.01	30635358
245	Phosphorylation	NLSAVASTEGTIEET CHHHHCCCCCCHHHH	28.79	30635358
248	Phosphorylation	AVASTEGTIEETLNE HHCCCCCCHHHHHHH	20.98	30635358
252	Phosphorylation	TEGTIEETLNEASRE CCCCHHHHHHHHHHH	23.30	30635358
257	Phosphorylation	EETLNEASRELPERA HHHHHHHHHHCHHHC	21.80	30635358
268	Ubiquitination	PERATNPFVNRESAE HHHCCCCCCCHHHCC	9.14	-
273	Phosphorylation	NPFVNRESAEFSVLE CCCCCHHHCCEEEEE	29.84	30635358
277	Phosphorylation	NRESAEFSVLEYSEM CHHHCCEEEEEEHHC	19.80	30635358
281	Phosphorylation	AEFSVLEYSEMGSSF CCEEEEEEHHCCCCC	13.03	30635358
282	Phosphorylation	EFSVLEYSEMGSSFN CEEEEEEHHCCCCCC	16.25	25619855
286	Phosphorylation	LEYSEMGSSFNGSPK EEEHHCCCCCCCCCC	30.37	30635358
287	Phosphorylation	EYSEMGSSFNGSPKG EEHHCCCCCCCCCCC	19.59	30635358
291	Phosphorylation	MGSSFNGSPKGESAM CCCCCCCCCCCCCCE	25.25	25619855
311	Phosphorylation	KEEVIVRSKDKEDLV CCEEEECCCCHHHHE	34.02	27742792
312	Ubiquitination	EEVIVRSKDKEDLVC CEEEECCCCHHHHEE	63.35	-
319	Ubiquitination	KDKEDLVCSAALHNP CCHHHHEEEHHHCCC	2.73	27667366
320	Phosphorylation	DKEDLVCSAALHNPQ CHHHHEEEHHHCCCC	14.75	25619855
329	Phosphorylation	ALHNPQESPATLTKV HHCCCCCCCCCHHHH	18.00	25521595
332	Phosphorylation	NPQESPATLTKVVKE CCCCCCCCHHHHHHC	38.04	25619855
334	Phosphorylation	QESPATLTKVVKEDG CCCCCCHHHHHHCCC	19.89	25619855
335	Ubiquitination	ESPATLTKVVKEDGV CCCCCHHHHHHCCCC	48.41	-
344	Phosphorylation	VKEDGVMSPEKTMDI HHCCCCCCHHHHHHH	27.74	25521595
347	Ubiquitination	DGVMSPEKTMDIFNE CCCCCHHHHHHHHHH	53.16	27667366
348	Phosphorylation	GVMSPEKTMDIFNEM CCCCHHHHHHHHHHH	20.58	23527152
366	Ubiquitination	VVAPVREEYADFKPF EEECCCHHHCCCCCH	35.14	27667366
371	Acetylation	REEYADFKPFEQAWE CHHHCCCCCHHHHHC	49.71	21728379
371	Ubiquitination	REEYADFKPFEQAWE CHHHCCCCCHHHHHC	49.71	27667366
380	Ubiquitination	FEQAWEVKDTYEGSR HHHHHCCCCCCCCHH	32.60	-
382	Phosphorylation	QAWEVKDTYEGSRDV HHHCCCCCCCCHHHH	20.11	25159016
383	Phosphorylation	AWEVKDTYEGSRDVL HHCCCCCCCCHHHHH	28.55	25159016
403	Ubiquitination	MESKVDKKCFEDSLE CHHHHCHHHHHHHHH	39.43	-
408	Phosphorylation	DKKCFEDSLEQKGHG CHHHHHHHHHHCCCC	26.97	24899341
426	Phosphorylation	ESRNENASFPRTPEL CCCCCCCCCCCCHHH	47.57	25159016
430	Phosphorylation	ENASFPRTPELVKDG CCCCCCCCHHHHCCC	22.73	25521595
435	Ubiquitination	PRTPELVKDGSRAYI CCCHHHHCCCCEEEE	69.83	27667366
443	Phosphorylation	DGSRAYITCDSFSSA CCCEEEEEECCCCCC	9.51	29899451
444	S-palmitoylation	GSRAYITCDSFSSAT CCEEEEEECCCCCCC	2.75	28680068
446	Phosphorylation	RAYITCDSFSSATES EEEEEECCCCCCCCC	29.22	29899451
448	Phosphorylation	YITCDSFSSATESTA EEEECCCCCCCCCHH	24.02	29899451
449	Phosphorylation	ITCDSFSSATESTAA EEECCCCCCCCCHHH	36.88	21183079
485	Phosphorylation	ERKAQIITEKTSPKT HHHHHHHCCCCCCCC	32.81	24925903
487	Ubiquitination	KAQIITEKTSPKTSN HHHHHCCCCCCCCCC	45.73	27667366
488	Phosphorylation	AQIITEKTSPKTSNP HHHHCCCCCCCCCCC	43.99	24925903
489	Phosphorylation	QIITEKTSPKTSNPF HHHCCCCCCCCCCCE	35.15	24925903
492	Phosphorylation	TEKTSPKTSNPFLVA CCCCCCCCCCCEEEE	36.80	25159016
503	Phosphorylation	FLVAIHDSEADYVTT EEEEEECCCCCEEEC	22.11	25159016
507	Phosphorylation	IHDSEADYVTTDNLS EECCCCCEEECCCHH	13.52	29514104
509	O-linked_Glycosylation	DSEADYVTTDNLSKV CCCCCEEECCCHHHH	23.39	28528544
517	Phosphorylation	TDNLSKVTEAVVATM CCCHHHHCHHHHHHC	23.20	30635358
523	Phosphorylation	VTEAVVATMPEGLTP HCHHHHHHCCCCCCH	22.96	30635358
529	Phosphorylation	ATMPEGLTPDLVQEA HHCCCCCCHHHHHHH	26.13	30635358
539	Phosphorylation	LVQEACESELNEATG HHHHHHHHHHHHHHC	47.47	30635358
648	Phosphorylation	AMSVALKTSDSKEEI HHHHHHHCCCCHHHH	38.32	26239621
649	Phosphorylation	MSVALKTSDSKEEIK HHHHHHCCCCHHHHC	38.00	26239621
651	Phosphorylation	VALKTSDSKEEIKEP HHHHCCCCHHHHCCC	41.56	26239621
652	Ubiquitination	ALKTSDSKEEIKEPE HHHCCCCHHHHCCCH	65.44	-
656	Ubiquitination	SDSKEEIKEPESFNA CCCHHHHCCCHHHHH	71.18	-
660	Phosphorylation	EEIKEPESFNAAAQE HHHCCCHHHHHHHHH	34.22	26239621
672	Phosphorylation	AQEAEAPYISIACDL HHHCCCCEEHHHHHH	17.85	23984901
674	Phosphorylation	EAEAPYISIACDLIK HCCCCEEHHHHHHHH	9.78	23984901
683	Phosphorylation	ACDLIKETKLSTEPS HHHHHHHCCCCCCCC	32.08	22324799
684	Ubiquitination	CDLIKETKLSTEPSP HHHHHHCCCCCCCCC	41.34	-
686	Phosphorylation	LIKETKLSTEPSPEF HHHHCCCCCCCCCCC	32.07	24925903
687	Phosphorylation	IKETKLSTEPSPEFS HHHCCCCCCCCCCCC	63.45	22324799
690	Phosphorylation	TKLSTEPSPEFSNYS CCCCCCCCCCCCCHH	30.72	25521595
694	Phosphorylation	TEPSPEFSNYSEIAK CCCCCCCCCHHHHHH	32.94	25159016
696	Phosphorylation	PSPEFSNYSEIAKFE CCCCCCCHHHHHHHH	13.39	25159016
697	Phosphorylation	SPEFSNYSEIAKFEK CCCCCCHHHHHHHHH	27.12	25159016
701	Ubiquitination	SNYSEIAKFEKSVPD CCHHHHHHHHHCCCC	60.77	-
705	Phosphorylation	EIAKFEKSVPDHCEL HHHHHHHCCCCCCEE	31.52	25293948
716	Phosphorylation	HCELVDDSSPESEPV CCEECCCCCCCCCCC	43.24	19060867
717	Phosphorylation	CELVDDSSPESEPVD CEECCCCCCCCCCCC	39.41	19060867
720	Phosphorylation	VDDSSPESEPVDLFS CCCCCCCCCCCCCCC	51.05	21183079
727	Phosphorylation	SEPVDLFSDDSIPEV CCCCCCCCCCCCCCC	48.05	19060867
730	Phosphorylation	VDLFSDDSIPEVPQT CCCCCCCCCCCCCCC	45.06	19060867
737	Phosphorylation	SIPEVPQTQEEAVML CCCCCCCCHHHHHHH	31.70	25293948
748	Phosphorylation	AVMLMKESLTEVSET HHHHHHHHHHHHHHH	34.76	24899341
750	Phosphorylation	MLMKESLTEVSETVT HHHHHHHHHHHHHHH	43.55	28066266
753	Phosphorylation	KESLTEVSETVTQHK HHHHHHHHHHHHHHH	22.71	22324799
762	Ubiquitination	TVTQHKHKERLSASP HHHHHHHHHHHCCCH	49.70	-
766	Phosphorylation	HKHKERLSASPQEVG HHHHHHHCCCHHHCC	32.68	25521595
768	Phosphorylation	HKERLSASPQEVGKP HHHHHCCCHHHCCHH	24.60	25521595
774	Ubiquitination	ASPQEVGKPYLESFQ CCHHHCCHHHHHHCC	35.35	-
776	Phosphorylation	PQEVGKPYLESFQPN HHHCCHHHHHHCCCC	26.96	26239621
779	Phosphorylation	VGKPYLESFQPNLHI CCHHHHHHCCCCCEE	26.96	25159016
787	Phosphorylation	FQPNLHITKDAASNE CCCCCEECCCCCCCC	16.48	20415495
800	Ubiquitination	NEIPTLTKKETISLQ CCCCCCCHHHEEEEE	52.29	-
816	Phosphorylation	EEFNTAIYSNDDLLS HHHHHHHHCCHHHHC	10.04	29899451
817	Phosphorylation	EFNTAIYSNDDLLSS HHHHHHHCCHHHHCC	27.89	25338131
823	Phosphorylation	YSNDDLLSSKEDKMK HCCHHHHCCHHHHHH	46.81	29899451
824	Phosphorylation	SNDDLLSSKEDKMKE CCHHHHCCHHHHHHH	39.78	25338131
832	Phosphorylation	KEDKMKESETFSDSS HHHHHHHCCCCCCCC	36.10	24925903
834	Phosphorylation	DKMKESETFSDSSPI HHHHHCCCCCCCCCE	37.40	24925903
836	Phosphorylation	MKESETFSDSSPIEI HHHCCCCCCCCCEEE	43.96	24925903
838	Phosphorylation	ESETFSDSSPIEIID HCCCCCCCCCEEEHH	36.49	24925903
839	Phosphorylation	SETFSDSSPIEIIDE CCCCCCCCCEEEHHC	34.58	24925903
841	Ubiquitination	TFSDSSPIEIIDEFP CCCCCCCEEEHHCCC	6.84	27667366
849	Phosphorylation	EIIDEFPTFVSAKDD EEHHCCCCEEECCCC	41.83	29119230
852	Phosphorylation	DEFPTFVSAKDDSPK HCCCCEEECCCCCCH	25.96	24925903
857	Phosphorylation	FVSAKDDSPKEYTDL EEECCCCCCHHCCCC	48.26	21930439
861	Phosphorylation	KDDSPKEYTDLEVSN CCCCCHHCCCCCCCC	16.22	27742792
862	Phosphorylation	DDSPKEYTDLEVSNK CCCCHHCCCCCCCCH	34.89	25619855
877	Phosphorylation	SEIANVQSGANSLPC HHHCCCCCCCCCCCH	35.27	25159016
881	Phosphorylation	NVQSGANSLPCSELP CCCCCCCCCCHHCCC	32.90	25159016
884	Glutathionylation	SGANSLPCSELPCDL CCCCCCCHHCCCCCC	6.31	24333276
884	S-palmitoylation	SGANSLPCSELPCDL CCCCCCCHHCCCCCC	6.31	28680068
892	Phosphorylation	SELPCDLSFKNTYPK HCCCCCCCCCCCCCC	22.41	-
905	Phosphorylation	PKDEAHVSDEFSKSR CCCHHHCCHHHHCCC	22.89	30635358
909	Phosphorylation	AHVSDEFSKSRSSVS HHCCHHHHCCCCCCC	27.89	27742792
914	Phosphorylation	EFSKSRSSVSKVPLL HHHCCCCCCCCCCEE	29.33	29899451
916	Phosphorylation	SKSRSSVSKVPLLLP HCCCCCCCCCCEECC	29.86	18779572
917	Ubiquitination	KSRSSVSKVPLLLPN CCCCCCCCCCEECCC	45.79	-
926	Phosphorylation	PLLLPNVSALESQIE CEECCCHHHHHHHHH	33.50	29899451
939	Ubiquitination	IEMGNIVKPKVLTKE HHHCCCCCCEECCHH	35.01	-
953	Phosphorylation	EAEEKLPSDTEKEDR HHHHHCCCCCCCHHH	68.54	25521595
955	Phosphorylation	EEKLPSDTEKEDRSL HHHCCCCCCCHHHCH	53.98	27742792
957	Ubiquitination	KLPSDTEKEDRSLTA HCCCCCCCHHHCHHH	67.99	27667366
961	Phosphorylation	DTEKEDRSLTAVLSA CCCCHHHCHHHHHHH	42.25	25521595
963	Phosphorylation	EKEDRSLTAVLSAEL CCHHHCHHHHHHHHC	18.90	28066266
967	Phosphorylation	RSLTAVLSAELNKTS HCHHHHHHHHCCCCC	17.07	18779572
974	Phosphorylation	SAELNKTSVVDLLYW HHHCCCCCCEEEEEC	23.04	23649490
1023	Phosphorylation	ALLSVTISFRIYKGV HHHHHHHHHHHHHHH	10.10	28973931
1037	Ubiquitination	VIQAIQKSDEGHPFR HHHHHHHCCCCCCCH	25.23	27667366
1060	Ubiquitination	ISEELVQKYSNSALG CCHHHHHHHCCCCHH	43.07	-
1061	Phosphorylation	SEELVQKYSNSALGH CHHHHHHHCCCCHHH	8.94	25177544
1064	Phosphorylation	LVQKYSNSALGHVNS HHHHHCCCCHHHHHH	20.94	28059163
1071	Phosphorylation	SALGHVNSTIKELRR CCHHHHHHHHHHHHH	30.35	28542873
1074	Acetylation	GHVNSTIKELRRLFL HHHHHHHHHHHHHHC	51.27	-
1074	Ubiquitination	GHVNSTIKELRRLFL HHHHHHHHHHHHHHC	51.27	22790023
1141	Ubiquitination	HYLGLANKSVKDAMA HHHHHCCHHHHHHHH	51.52	22790023
1153	Ubiquitination	AMAKIQAKIPGLKRK HHHHHHHHCCCHHHC	32.81	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
156	T	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RTN4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RTN4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBX32_MOUSE	Fbxo32	physical	21964591
RTN4R_MOUSE	Rtn4r	physical	12839991
NECD_MOUSE	Ndn	physical	19386232

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RTN4_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-105, AND MASSSPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145 AND SER-344, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-105 AND SER-165,AND MASS SPECTROMETRY.	17242355 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145; SER-165; THR-171;SER-426; SER-857 AND TYR-861, AND MASS SPECTROMETRY.	17114649 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145; SER-690; SER-836AND SER-839, AND MASS SPECTROMETRY.	15345747 [Abstract]