AR6P4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AR6P4_MOUSE
• UniProt AC: Q9JM93
• Protein Name: ADP-ribosylation factor-like protein 6-interacting protein 4
• Gene Name: Arl6ip4
• Organism: Mus musculus (Mouse).
• Sequence Length: 229
• Subcellular Localization: Nucleus, nucleolus. Nucleus speckle.
• Protein Description: Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site..
• Protein Sequence: MAHVGSRKRSRSRSRSRSGRRGSEKRSKRSSKDASRNCSASRSQGHKAGSASGVEERSKHKAQRTSRSSSTSSSSSSSSSASSSSSSDGRKKRAKHKEKKRKKKKKKRKKKLKKRVKEKAVAVHQAEALPGPSLDQWHRSAGEDNDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTRLIKGDGEVLEEIVTKERHREINKQATRGDGLAFQMRTGLLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAHVGSRKRSRSR --CCCCCCCCCHHHC	33.27	24719451
50	Phosphorylation	SQGHKAGSASGVEER HHCCCCCCCCCHHHH	24.91	25521595
52	Phosphorylation	GHKAGSASGVEERSK CCCCCCCCCHHHHHH	45.10	23684622
133	Phosphorylation	AEALPGPSLDQWHRS HHCCCCCCHHHHHHH	50.96	26745281
140	Phosphorylation	SLDQWHRSAGEDNDG CHHHHHHHCCCCCCC	27.95	26824392
151	Phosphorylation	DNDGPVLTDEQKSRI CCCCCCCCHHHHHHH	37.41	25619855
174	Phosphorylation	EEWDARQSVIRKVVD HHHHHHHHHHHHHCC	17.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AR6P4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AR6P4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AR6P4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AR6P4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140, AND MASSSPECTROMETRY.
PubMed: 17203969