ENOPH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENOPH_MOUSE
• UniProt AC: Q8BGB7
• Protein Name: Enolase-phosphatase E1 {ECO:0000255|HAMAP-Rule:MF_03117}
• Gene Name: Enoph1
• Organism: Mus musculus (Mouse).
• Sequence Length: 257
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)..
• Protein Sequence: MVVVSVPAEVTVILLDIEGTTTPIAFVKDVLFPYIKENVKEYLQTHWEEEECQQDVSLLRKQAEEDAHLDGAVPIPVASGSDLQQMIQAVVDNVYWQMSHDRKTTALKQLQGHMWKAAFTAGRMKAEFFADVVPAVRRWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELIDGHFDTKIGHKVDSESYRKIADSIGCSTNNILFLTDVTVEASAAEEADVHVAVVVRPGNAGLTDDEKTYYNLITSFSELYLPST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Ubiquitination	DVLFPYIKENVKEYL HHHHHHHHHHHHHHH	37.08	22790023
36	Acetylation	DVLFPYIKENVKEYL HHHHHHHHHHHHHHH	37.08	23236377
44	Ubiquitination	ENVKEYLQTHWEEEE HHHHHHHHHHCCHHH	30.34	27667366
150	Phosphorylation	GMKVYIYSSGSVEAQ CCEEEEEECCCHHHH	20.75	26643407
151	Phosphorylation	MKVYIYSSGSVEAQK CEEEEEECCCHHHHH	20.37	26643407
153	Phosphorylation	VYIYSSGSVEAQKLL EEEEECCCHHHHHHH	20.80	26643407
164	Phosphorylation	QKLLFGHSTEGDILE HHHHCCCCCCCCHHH	28.65	26643407
165	Phosphorylation	KLLFGHSTEGDILEL HHHCCCCCCCCHHHH	38.01	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENOPH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENOPH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENOPH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ENOPH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.