KDM3B_MOUSE - dbPTM
KDM3B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KDM3B_MOUSE
UniProt AC Q6ZPY7
Protein Name Lysine-specific demethylase 3B
Gene Name Kdm3b
Organism Mus musculus (Mouse).
Sequence Length 1562
Subcellular Localization Nucleus.
Protein Description Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate May have tumor suppressor activity (By similarity)..
Protein Sequence MADAAASPVGKRLLLLFADPTASASASAPTAAAVVSGDPGPALRTRAWRAGTVRAMSGAVPQDLAIFVEFDGCNWKQHSWVKVHAEDVLALLLEGSLVWAPRKDPVLLQGTRVPVAQWPALTFTPLVDKLGLGSVVPVEYLVDRELRFLSDANGMHLFQMGTDVQNQILLEHAALRETVNALISDQKLQEIFSRGPYSVQGHRVKVYQPEGEEVWLCGVVSRQDSVTRLMEVSITETGEVKSVDPRLTHVMLMDSSTPQSENSRNSSLASSGFGVSLSSLSQPLTFGSGRSQSNGVLATDNKPLGFSFSCSSASESQKDSDLSKNLFFQCMSQNVPSTNYLSRVSESVADDSSSRDSFTQSLESLTSGLCKGRSVLGADTQPGPKAGSSVDRKVPAESMPTLTPAFPRSLLNTRTPENHENLFLQPPKLSREEPSNPFLAFVEKVEHSPFSSFVSQASGSSSSATSVTSKATASWPESHSSAESAPLAKKKPLFITTDSSKLVSGVLGSALSTGSPSLSAVGNGRSSSPTNSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTFSTVFGRHSGSFLSAPAEFAQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKSGLKGIPEHLMGKLGPNGERSAELLLGKGKGKQAPKGRPRTAPLKVGQSVLKDVSKVRKLKQSGEPFLQDGSCINVAPHLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRLVFTRKGVLRVEGFLSPQQSDPDAMNLWIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVREMCDVCETTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQSKSVLRPAVTNGISQLPSVTPSASSGNETTFSSGGGAAAVTNPEPDQVPKGAGTDGRSEEPLKAEGSASNSNSELKAIRPPCPDTAPPSSALHWLADLATQKAKEETKDAGSLRSVLNKESHSPFGLDSFNSTAKVSPLTPKLFNSLLLGPTASNSKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFSSSSAVAKSKASLPDFLDHIIASVVENKKTSDPSKRSCNLTDTQKEVKEMAMGLNVLDPHTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKLKDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGIPVGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQILRKRLFEEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVGTLKAHESKLARS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MADAAASPV
------CCCHHCCCC		26.84-
7Phosphorylation-MADAAASPVGKRLL
-CCCHHCCCCHHEEE		18.52-
242PhosphorylationTETGEVKSVDPRLTH
ECCCCEEECCCCCEE		36.61-
248PhosphorylationKSVDPRLTHVMLMDS
EECCCCCEEEEEECC		17.44-
255PhosphorylationTHVMLMDSSTPQSEN
EEEEEECCCCCCCCC		23.34-
293PhosphorylationFGSGRSQSNGVLATD
CCCCCCCCCCEEECC		36.4827841257
345PhosphorylationTNYLSRVSESVADDS
CCHHHHHCHHHCCCC		24.0425619855
347PhosphorylationYLSRVSESVADDSSS
HHHHHCHHHCCCCCC		18.3325619855
352PhosphorylationSESVADDSSSRDSFT
CHHHCCCCCCCHHHH		30.6621082442
353PhosphorylationESVADDSSSRDSFTQ
HHHCCCCCCCHHHHH		36.0725619855
354PhosphorylationSVADDSSSRDSFTQS
HHCCCCCCCHHHHHH		44.0227087446
357PhosphorylationDDSSSRDSFTQSLES
CCCCCCHHHHHHHHH		29.1427087446
359PhosphorylationSSSRDSFTQSLESLT
CCCCHHHHHHHHHHH		22.6227087446
361PhosphorylationSRDSFTQSLESLTSG
CCHHHHHHHHHHHCC		30.9225619855
364PhosphorylationSFTQSLESLTSGLCK
HHHHHHHHHHCCCCC		42.0925619855
366PhosphorylationTQSLESLTSGLCKGR
HHHHHHHHCCCCCCC		29.9925619855
367PhosphorylationQSLESLTSGLCKGRS
HHHHHHHCCCCCCCC		34.7525619855
409PhosphorylationLTPAFPRSLLNTRTP
CCCCCCHHHCCCCCC		37.1326643407
413PhosphorylationFPRSLLNTRTPENHE
CCHHHCCCCCCCCCC		35.5726643407
415PhosphorylationRSLLNTRTPENHENL
HHHCCCCCCCCCCCC		32.6826643407
448PhosphorylationFVEKVEHSPFSSFVS
HHEECCCCCCHHHHH		17.7126643407
451PhosphorylationKVEHSPFSSFVSQAS
ECCCCCCHHHHHHCC		26.6726643407
452PhosphorylationVEHSPFSSFVSQASG
CCCCCCHHHHHHCCC		30.0126643407
455PhosphorylationSPFSSFVSQASGSSS
CCCHHHHHHCCCCCC		20.3026643407
497O-linked_GlycosylationKKPLFITTDSSKLVS
CCCEEEECCHHHHHH		29.1255412337
497PhosphorylationKKPLFITTDSSKLVS
CCCEEEECCHHHHHH		29.12-
504PhosphorylationTDSSKLVSGVLGSAL
CCHHHHHHHHHHHHH		33.3522942356
509PhosphorylationLVSGVLGSALSTGSP
HHHHHHHHHHHCCCC		23.1326643407
512PhosphorylationGVLGSALSTGSPSLS
HHHHHHHHCCCCCCH		30.3626643407
513PhosphorylationVLGSALSTGSPSLSA
HHHHHHHCCCCCCHH		42.3926643407
515PhosphorylationGSALSTGSPSLSAVG
HHHHHCCCCCCHHCC		16.0527180971
517PhosphorylationALSTGSPSLSAVGNG
HHHCCCCCCHHCCCC		36.3326745281
519PhosphorylationSTGSPSLSAVGNGRS
HCCCCCCHHCCCCCC		25.8326643407
526PhosphorylationSAVGNGRSSSPTNSL
HHCCCCCCCCCCCCC		36.2425521595
527PhosphorylationAVGNGRSSSPTNSLT
HCCCCCCCCCCCCCC		38.6924453211
528PhosphorylationVGNGRSSSPTNSLTQ
CCCCCCCCCCCCCCC		36.6724925903
530PhosphorylationNGRSSSPTNSLTQPI
CCCCCCCCCCCCCCC		39.1124925903
532PhosphorylationRSSSPTNSLTQPIEM
CCCCCCCCCCCCCCC		34.9624925903
534PhosphorylationSSPTNSLTQPIEMPT
CCCCCCCCCCCCCCC		31.9224925903
541PhosphorylationTQPIEMPTLSSSPTE
CCCCCCCCCCCCCCC		37.6524925903
543PhosphorylationPIEMPTLSSSPTEER
CCCCCCCCCCCCCCC		31.1124925903
544PhosphorylationIEMPTLSSSPTEERP
CCCCCCCCCCCCCCC		43.3724925903
545PhosphorylationEMPTLSSSPTEERPT
CCCCCCCCCCCCCCC		32.2525521595
547PhosphorylationPTLSSSPTEERPTVG
CCCCCCCCCCCCCCC		53.0424925903
552PhosphorylationSPTEERPTVGPGQQD
CCCCCCCCCCCCCCC		44.2924925903
565PhosphorylationQDNPLLKTFSTVFGR
CCCHHHHHHHHHHCC		23.8426643407
567PhosphorylationNPLLKTFSTVFGRHS
CHHHHHHHHHHCCCC		28.9727600695
568PhosphorylationPLLKTFSTVFGRHSG
HHHHHHHHHHCCCCC		18.7026643407
574PhosphorylationSTVFGRHSGSFLSAP
HHHHCCCCCCCCCCC		34.4729899451
576PhosphorylationVFGRHSGSFLSAPAE
HHCCCCCCCCCCCHH		26.4826643407
579PhosphorylationRHSGSFLSAPAEFAQ
CCCCCCCCCCHHHHH		30.1426643407
599PhosphorylationFEAVKRFSLDERSLA
HHHHHHCCCCHHHHH		38.6626824392
1052PhosphorylationRSVLNKESHSPFGLD
HHHHCCCCCCCCCCC		30.7626745281
1054PhosphorylationVLNKESHSPFGLDSF
HHCCCCCCCCCCCCC		31.0725266776
1060PhosphorylationHSPFGLDSFNSTAKV
CCCCCCCCCCCCCCC		31.2226643407
1068PhosphorylationFNSTAKVSPLTPKLF
CCCCCCCCCCCHHHH		17.3128066266
1071PhosphorylationTAKVSPLTPKLFNSL
CCCCCCCCHHHHHHH		23.0429514104
1073UbiquitinationKVSPLTPKLFNSLLL
CCCCCCHHHHHHHHC		61.55-
1088UbiquitinationGPTASNSKTEGSSLR
CCCCCCCCCCCCCHH		55.64-
1187S-nitrosylationHTSHSWLCDGRLLCL
CCCCCCCCCCEEEEE		4.1922178444
1187S-nitrosocysteineHTSHSWLCDGRLLCL
CCCCCCCCCCEEEEE		4.19-
1507PhosphorylationKVAEDFVSPEHVKHC
HHHHCCCCHHHHHHH		25.2726745281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KDM3B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KDM3B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KDM3B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KDM3B_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KDM3B_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-599, AND MASSSPECTROMETRY.

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