FZD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FZD3_MOUSE
• UniProt AC: Q61086
• Protein Name: Frizzled-3
• Gene Name: Fzd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 666
• Subcellular Localization: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell surface . Apical cell membrane ; Multi-pass membrane protein. Colocalizes with FZD6 at the apical face of the cell.
• Protein Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner..
• Protein Sequence: MAVSWIVFDLWLLTVFLGQIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNLVGDPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSVHSKVSSYHGSLHRSRDGRYTPCSYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIEEDGTSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	N-linked_Glycosylation	MCQDLPYNTTFMPNL HCCCCCCCCCCCHHH	30.61	-
200	Phosphorylation	YFRREELSFARYFIG CCCHHHHHHHHHHHH	21.82	28059163
265	N-linked_Glycosylation	LEDRVACNASSPAQY HHCHHCCCCCCCCCH	32.87	-
356	N-linked_Glycosylation	MNKIEGDNISGVCFV CCCCCCCCCCCEEEE	40.98	-
504	S-palmitoylation	WVGSKKTCFEWASFF ECCCCCHHHHHHHHH	3.90	28680068
509	Phosphorylation	KTCFEWASFFHGRRK CHHHHHHHHHCCCCH	29.53	21316586
535	Phosphorylation	QEPDFAQSLLRDPNT HCCHHHHHHHCCCCC	26.41	29899451
542	Phosphorylation	SLLRDPNTPIIRKSR HHHCCCCCCEEECCC	22.66	21316586
563	Phosphorylation	TSTHASSTQLAMVDD CCCCCCCCEEEEECC	25.71	21316586
577	Phosphorylation	DQRSKAGSVHSKVSS CCHHHCCCCHHHHHH	22.86	21316586
584	Phosphorylation	SVHSKVSSYHGSLHR CCHHHHHHCCCCCCC	24.92	29899451
588	Phosphorylation	KVSSYHGSLHRSRDG HHHHCCCCCCCCCCC	14.00	27841257
613	Phosphorylation	EERLPHGSMSRLTDH HHHCCCCCHHHHCCC	15.56	28066266
615	Phosphorylation	RLPHGSMSRLTDHSR HCCCCCHHHHCCCCC	26.32	28066266
625	Phosphorylation	TDHSRHSSSHRLNEQ CCCCCCCHHHHCCHH	24.84	21316586
637	Phosphorylation	NEQSRHSSIRDLSNN CHHHCCCCHHHHCCC	18.60	21316586
664	Phosphorylation	RVIEEDGTSA----- CEECCCCCCC-----	33.53	20415495
665	Phosphorylation	VIEEDGTSA------ EECCCCCCC------	37.19	23527152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FZD3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FZD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FZD3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FZD3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.