dbPTM

DVL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DVL2_MOUSE
UniProt AC	Q60838
Protein Name	Segment polarity protein dishevelled homolog DVL-2
Gene Name	Dvl2
Organism	Mus musculus (Mouse).
Sequence Length	736
Subcellular Localization	Cell membrane Peripheral membrane protein Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Nucleus . Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization (PubMed:21189423). L
Protein Description	Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling..
Protein Sequence	MAGSSAGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDTPQPEVAPPAHESRTELVPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRDRPRRRDSSEHGAGGHRPGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRMERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESELSSRGGSLRRGGEPGGTGDGGPPPSRGSTGAPPNLRALPGLHPYGAPSGMALPYNPMMVVMMPPPPPPVSTAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAGSSAGGGGV ----CCCCCCCCCCC	13.89	29514104
27	Phosphorylation	LDEEETPYLVKIPVP CCCCCCCEEEEECCC	31.39	29514104
37	Methylation	KIPVPAERITLGDFK EECCCHHHEECCCHH	29.33	-
59	Phosphorylation	GAKYFFKSMDQDFGV CCHHHHEECCCCCCE	23.57	26643407
94	Phosphorylation	SWLVSSDTPQPEVAP EEEECCCCCCCCCCC	26.27	25338131
142	Phosphorylation	SFHPNVSSSHENLEP CCCCCCCCCCCCCCC	31.28	29514104
143	Phosphorylation	FHPNVSSSHENLEPE CCCCCCCCCCCCCCC	27.58	29514104
151	Phosphorylation	HENLEPETETESVVS CCCCCCCCCCCCHHH	59.95	29514104
155	Phosphorylation	EPETETESVVSLRRD CCCCCCCCHHHHCCC	34.93	29514104
158	Phosphorylation	TETESVVSLRRDRPR CCCCCHHHHCCCCCC	17.63	29514104
169	Phosphorylation	DRPRRRDSSEHGAGG CCCCCCCCCCCCCCC	35.50	24899341
170	Phosphorylation	RPRRRDSSEHGAGGH CCCCCCCCCCCCCCC	37.59	26824392
183	Phosphorylation	GHRPGGPSRLERHLA CCCCCCCCHHHHHHC	53.42	25777480
192	Phosphorylation	LERHLAGYESSSTLM HHHHHCCCCCCCCEE	13.66	28833060
194	Phosphorylation	RHLAGYESSSTLMTS HHHCCCCCCCCEECC	22.54	28833060
195	Phosphorylation	HLAGYESSSTLMTSE HHCCCCCCCCEECCC	18.53	25777480
196	Phosphorylation	LAGYESSSTLMTSEL HCCCCCCCCEECCCC	34.54	25777480
197	Phosphorylation	AGYESSSTLMTSELE CCCCCCCCEECCCCE	23.61	28833060
200	Phosphorylation	ESSSTLMTSELESTS CCCCCEECCCCEECC	23.35	28833060
201	Phosphorylation	SSSTLMTSELESTSL CCCCEECCCCEECCC	26.64	28833060
205	Phosphorylation	LMTSELESTSLGDSD EECCCCEECCCCCCC	35.60	28833060
206	Phosphorylation	MTSELESTSLGDSDE ECCCCEECCCCCCCC	20.70	28833060
207	Phosphorylation	TSELESTSLGDSDED CCCCEECCCCCCCCC	39.37	28833060
211	Phosphorylation	ESTSLGDSDEDDTMS EECCCCCCCCCCHHH	40.89	27087446
216	Phosphorylation	GDSDEDDTMSRFSSS CCCCCCCHHHHHCCH	29.39	28833060
218	Phosphorylation	SDEDDTMSRFSSSTE CCCCCHHHHHCCHHC	32.06	28833060
221	Phosphorylation	DDTMSRFSSSTEQSS CCHHHHHCCHHCHHH	23.44	25777480
222	Phosphorylation	DTMSRFSSSTEQSSA CHHHHHCCHHCHHHH	38.27	25777480
223	Phosphorylation	TMSRFSSSTEQSSAS HHHHHCCHHCHHHHH	34.46	25777480
224	Phosphorylation	MSRFSSSTEQSSASR HHHHCCHHCHHHHHH	39.74	25777480
227	Phosphorylation	FSSSTEQSSASRLLK HCCHHCHHHHHHHHH	22.95	25777480
228	Phosphorylation	SSSTEQSSASRLLKR CCHHCHHHHHHHHHH	29.92	25777480
230	Phosphorylation	STEQSSASRLLKRHR HHCHHHHHHHHHHHH	25.96	25777480
231	Methylation	TEQSSASRLLKRHRR HCHHHHHHHHHHHHH	43.70	-
250	Phosphorylation	RPPRMERTSSFSSVT CCCCCCCCCCCCCCC	18.54	23608596
252	Phosphorylation	PRMERTSSFSSVTDS CCCCCCCCCCCCCCC	28.65	23608596
289	Asymmetric dimethylarginine	IVGQSNERGDGGIYI EEECCCCCCCCCEEE	53.40	-
362	Phosphorylation	WDPSPQAYFTLPRNE CCCCCCCEEECCCCC	7.58	29514104
364	Phosphorylation	PSPQAYFTLPRNEPI CCCCCEEECCCCCCC	24.15	22006019
591	Phosphorylation	QHSEGSRSSGSTRSD CCCCCCCCCCCCCCC	40.52	-
592	Phosphorylation	HSEGSRSSGSTRSDG CCCCCCCCCCCCCCC	35.34	-
594	Phosphorylation	EGSRSSGSTRSDGGA CCCCCCCCCCCCCCC	23.69	-
595	Phosphorylation	GSRSSGSTRSDGGAG CCCCCCCCCCCCCCC	37.40	-
597	Phosphorylation	RSSGSTRSDGGAGRT CCCCCCCCCCCCCCC	40.47	-
614	Phosphorylation	PEERAPESKSGSGSE CHHCCCCCCCCCCCH	30.94	21659605
615	Ubiquitination	EERAPESKSGSGSES HHCCCCCCCCCCCHH	58.11	-
616	Phosphorylation	ERAPESKSGSGSESE HCCCCCCCCCCCHHH	47.69	26824392
618	Phosphorylation	APESKSGSGSESELS CCCCCCCCCCHHHHH	46.35	25521595
620	Phosphorylation	ESKSGSGSESELSSR CCCCCCCCHHHHHHC	39.38	21659605
622	Phosphorylation	KSGSGSESELSSRGG CCCCCCHHHHHHCCC	45.60	26160508
625	Phosphorylation	SGSESELSSRGGSLR CCCHHHHHHCCCCCC	17.59	26160508
626	Phosphorylation	GSESELSSRGGSLRR CCHHHHHHCCCCCCC	47.79	25777480
630	Phosphorylation	ELSSRGGSLRRGGEP HHHHCCCCCCCCCCC	22.87	29514104
632	Symmetric dimethylarginine	SSRGGSLRRGGEPGG HHCCCCCCCCCCCCC	36.57	-
715	Phosphorylation	GSVPPELTASRQSFH CCCCHHHHCCHHHHH	22.41	27841257
717	Phosphorylation	VPPELTASRQSFHMA CCHHHHCCHHHHHHH	26.14	29233185
718	Methylation	PPELTASRQSFHMAM CHHHHCCHHHHHHHC	33.43	-
720	Phosphorylation	ELTASRQSFHMAMGN HHHCCHHHHHHHCCC	18.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
591	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
592	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
594	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
595	T	Phosphorylation	Kinase	CSNK1D	P48730	GPS
597	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DVL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DVL2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRC_MOUSE	Src	physical	19920076
HCK_MOUSE	Hck	physical	19920076
CSK2A_DROME	CkIIalpha	physical	10409711
VANG2_MOUSE	Vangl2	genetic	16116426
DVL3_MOUSE	Dvl3	genetic	19008950
AXIN1_MOUSE	Axin1	physical	15579909
VANG1_MOUSE	Vangl1	physical	15456783
VANG2_MOUSE	Vangl2	physical	15456783
PAR6A_MOUSE	Pard6a	physical	19379695
SMUF2_MOUSE	Smurf2	physical	19379695
SMUF1_MOUSE	Smurf1	physical	19379695
GBRL1_MOUSE	Gabarapl1	physical	21691068
ZBT17_MOUSE	Zbtb17	physical	25558878

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DVL2_MOUSE

Related Literatures of Post-Translational Modification