UniProt ID | PAR6A_MOUSE | |
---|---|---|
UniProt AC | Q9Z101 | |
Protein Name | Partitioning defective 6 homolog alpha | |
Gene Name | Pard6a | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 346 | |
Subcellular Localization | Cytoplasm. Cell membrane. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with GTP-bound CDC42 | |
Protein Description | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. [PubMed: 15761148 Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (By similarity] | |
Protein Sequence | MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRTSVRGFQEFSRLLCVVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEGDSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPSSVGPGPTDPDSDDDSSDLVIENRHPPCSNGLSQGPLCWDLQPGCLLPGAGSSLPSLDSREQANSGWGNGMRGDVSGFSL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
106 (in isoform 2) | Phosphorylation | - | 11.38 | 29899451 | |
107 | Phosphorylation | SSGLAFASNSLQRRK CCHHHHHCHHHHHHC | 22.09 | 28066266 | |
108 (in isoform 2) | Phosphorylation | - | 43.22 | 29899451 | |
109 | Phosphorylation | GLAFASNSLQRRKKG HHHHHCHHHHHHCCC | 24.31 | 26643407 | |
195 | Phosphorylation | RVPGIFISRLVRGGL CCCCCHHHHHHHCCH | 14.60 | 28285833 | |
264 | Phosphorylation | RGASGRLTGPSSVGP CCCCCCCCCCCCCCC | 45.76 | 30635358 | |
267 | Phosphorylation | SGRLTGPSSVGPGPT CCCCCCCCCCCCCCC | 38.71 | 30635358 | |
268 | Phosphorylation | GRLTGPSSVGPGPTD CCCCCCCCCCCCCCC | 33.94 | 30635358 | |
274 | Phosphorylation | SSVGPGPTDPDSDDD CCCCCCCCCCCCCCC | 67.11 | 20415495 | |
278 | Phosphorylation | PGPTDPDSDDDSSDL CCCCCCCCCCCCCCC | 48.61 | 24925903 | |
282 | Phosphorylation | DPDSDDDSSDLVIEN CCCCCCCCCCCEEEC | 32.52 | 24925903 | |
283 | Phosphorylation | PDSDDDSSDLVIENR CCCCCCCCCCEEECC | 41.79 | 24925903 | |
345 | Phosphorylation | RGDVSGFSL------ CCCCCCCCC------ | 36.37 | 20603020 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PAR6A_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PAR6A_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PAR6A_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
PARD3_MOUSE | Pard3 | physical | 16510873 | |
DVL2_MOUSE | Dvl2 | physical | 19379695 | |
SMUF2_MOUSE | Smurf2 | physical | 19379695 | |
PARD3_MOUSE | Pard3 | physical | 19379695 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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