PAR6A_MOUSE - dbPTM
PAR6A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PAR6A_MOUSE
UniProt AC Q9Z101
Protein Name Partitioning defective 6 homolog alpha
Gene Name Pard6a
Organism Mus musculus (Mouse).
Sequence Length 346
Subcellular Localization Cytoplasm. Cell membrane. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with GTP-bound CDC42
Protein Description Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. [PubMed: 15761148 Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (By similarity]
Protein Sequence MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRTSVRGFQEFSRLLCVVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEGDSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPSSVGPGPTDPDSDDDSSDLVIENRHPPCSNGLSQGPLCWDLQPGCLLPGAGSSLPSLDSREQANSGWGNGMRGDVSGFSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
106 (in isoform 2)Phosphorylation-11.3829899451
107PhosphorylationSSGLAFASNSLQRRK
CCHHHHHCHHHHHHC
22.0928066266
108 (in isoform 2)Phosphorylation-43.2229899451
109PhosphorylationGLAFASNSLQRRKKG
HHHHHCHHHHHHCCC
24.3126643407
195PhosphorylationRVPGIFISRLVRGGL
CCCCCHHHHHHHCCH
14.6028285833
264PhosphorylationRGASGRLTGPSSVGP
CCCCCCCCCCCCCCC
45.7630635358
267PhosphorylationSGRLTGPSSVGPGPT
CCCCCCCCCCCCCCC
38.7130635358
268PhosphorylationGRLTGPSSVGPGPTD
CCCCCCCCCCCCCCC
33.9430635358
274PhosphorylationSSVGPGPTDPDSDDD
CCCCCCCCCCCCCCC
67.1120415495
278PhosphorylationPGPTDPDSDDDSSDL
CCCCCCCCCCCCCCC
48.6124925903
282PhosphorylationDPDSDDDSSDLVIEN
CCCCCCCCCCCEEEC
32.5224925903
283PhosphorylationPDSDDDSSDLVIENR
CCCCCCCCCCEEECC
41.7924925903
345PhosphorylationRGDVSGFSL------
CCCCCCCCC------
36.3720603020

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PAR6A_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PAR6A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PAR6A_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PARD3_MOUSEPard3physical
16510873
DVL2_MOUSEDvl2physical
19379695
SMUF2_MOUSESmurf2physical
19379695
PARD3_MOUSEPard3physical
19379695

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PAR6A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, AND MASSSPECTROMETRY.

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