dbPTM

GBRL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GBRL1_MOUSE
UniProt AC	Q8R3R8
Protein Name	Gamma-aminobutyric acid receptor-associated protein-like 1
Gene Name	Gabarapl1
Organism	Mus musculus (Mouse).
Sequence Length	117
Subcellular Localization	Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane Lipid-anchor. Endoplasmic reticulum. Golgi apparatus. Cytoplasmic vesicle, autophagosome.
Protein Description	Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity)..
Protein Sequence	MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKFQYKEDH ------CCCCCCCCC	40.97	27667366
23	Ubiquitination	KEGEKIRKKYPDRVP HHHHHHHHHCCCCCC	61.20	-
24	Ubiquitination	EGEKIRKKYPDRVPV HHHHHHHHCCCCCCE	52.76	-
35	Acetylation	RVPVIVEKAPKARVP CCCEEEEECCCCCCC	60.12	130339
116	Phosphatidylethanolamine amidation	YSDESVYGK------ ECCCCCCCC------	27.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GBRL1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GBRL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GBRL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GBRL1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GBRL1_MOUSE

Related Literatures of Post-Translational Modification