VANG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VANG1_MOUSE
• UniProt AC: Q80Z96
• Protein Name: Vang-like protein 1
• Gene Name: Vangl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 526
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Sequence: MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQAPAGEPLLANDSARTGAEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPQILWREELKPCGAICEGLLISVSFKLLILLIGTWALFFRKQRADVPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDQNYKDIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRRARLVVAVEEAFIHIQRLQAEEQQKSPGEVMDPREAAQAIFPSMARALQKYLRTTRQQHYHSMESILQHLAFCITNSMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLISEEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIVLSEEFIDPKSHKFVLRLQSETSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	TESTYSGYSYYSSHS CCCCCCCCCCCCCCC	6.38	29514104
12	Phosphorylation	STYSGYSYYSSHSKK CCCCCCCCCCCCCCC	10.01	29514104
42	Phosphorylation	RNKDGRGSEKSVTIQ CCCCCCCCCCEEEEE	40.25	29514104
45	Phosphorylation	DGRGSEKSVTIQAPA CCCCCCCEEEEECCC	22.05	26824392
47	Phosphorylation	RGSEKSVTIQAPAGE CCCCCEEEEECCCCC	17.92	26824392
64	Phosphorylation	LANDSARTGAEEVQD CCCCCCCCCCCHHCC	40.22	27087446
82	Phosphorylation	GETTTAITGTSEHSI CEEEEEEECCCCCCC	31.76	21082442
84	Phosphorylation	TTTAITGTSEHSISQ EEEEEECCCCCCCCH	23.45	25338131
85	Phosphorylation	TTAITGTSEHSISQE EEEEECCCCCCCCHH	34.36	21183079
88	Phosphorylation	ITGTSEHSISQEDIA EECCCCCCCCHHHHH	21.63	27087446
90	Phosphorylation	GTSEHSISQEDIARI CCCCCCCCHHHHHHH	30.45	27087446
314	Phosphorylation	HMAGLKVYNVDGPSN HHCCCEEEECCCCCC	14.10	29514104
320	Phosphorylation	VYNVDGPSNNATGQS EEECCCCCCCCCHHH	48.52	29514104
340	Phosphorylation	AAARRRDSSHNELYY HHHHHCCCCCCCHHH	31.52	19060867
341	Phosphorylation	AARRRDSSHNELYYE HHHHCCCCCCCHHHH	34.32	-
346	Phosphorylation	DSSHNELYYEEAEHE CCCCCCHHHHHHHHH	11.58	29514104
522	Phosphorylation	KFVLRLQSETSV--- CEEEEEECCCCC---	47.65	25521595
524	Phosphorylation	VLRLQSETSV----- EEEEECCCCC-----	39.78	23984901
525	Phosphorylation	LRLQSETSV------ EEEECCCCC------	23.06	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VANG1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VANG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VANG1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DVL1_MOUSE	Dvl1	physical	15456783
DVL2_MOUSE	Dvl2	physical	15456783
DVL3_MOUSE	Dvl3	physical	15456783
CASP8_HUMAN	CASP8	physical	26496610
2ABA_HUMAN	PPP2R2A	physical	26496610
EDRF1_HUMAN	EDRF1	physical	26496610
TECT3_HUMAN	TCTN3	physical	26496610
NARF_HUMAN	NARF	physical	26496610
SIR6_HUMAN	SIRT6	physical	26496610
IF122_HUMAN	IFT122	physical	26496610
DYHC2_HUMAN	DYNC2H1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.