PZRN3_MOUSE - dbPTM
PZRN3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PZRN3_MOUSE
UniProt AC Q69ZS0
Protein Name E3 ubiquitin-protein ligase PDZRN3
Gene Name Pdzrn3
Organism Mus musculus (Mouse).
Sequence Length 1063
Subcellular Localization Cell junction, synapse . Cytoplasm . Localizes to the postsynaptic region of neuromuscular junctions.
Protein Description E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation..
Protein Sequence MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARCRHAGCGQLLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPCVDNQDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPASESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPASHDYYDPNDYMGDIHQDMDREELELEEVGLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGEDATASANPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDVDYLGIPEDECERFRELLELKCQVQSASPYSLYYPSSPLDAAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHHSGFRNYNTSVDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRVAEGSSEGATANIEAYRPSPKNLLAITEDPEVSTPSYNPSAKELDPSQALEIKERRGSDGSRSPTASPKLGNAYLPSYHHSPYKHAHIPAHAQHYQSYMHLIQQKSAVEYAQSQMSLVSMCKDLNSSNSVEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQASDDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
427PhosphorylationVGLYRMNSQDKLGLT
HEEEECCCCCCEECE		30.3422817900
439PhosphorylationGLTVCYRTDDEDDIG
ECEEEEECCCCCCEE		22.7123608596
448PhosphorylationDEDDIGIYISEIDPN
CCCCEEEEEEECCCC		7.99-
574PhosphorylationKDSGVGRTDESTRND
CCCCCCCCCCCCCCC		37.8826160508
577PhosphorylationGVGRTDESTRNDESS
CCCCCCCCCCCCCCC		35.1626160508
578PhosphorylationVGRTDESTRNDESSE
CCCCCCCCCCCCCCC		31.2926160508
583PhosphorylationESTRNDESSEQENNG
CCCCCCCCCCCCCCC		41.8825619855
584PhosphorylationSTRNDESSEQENNGE
CCCCCCCCCCCCCCC		41.0525619855
669PhosphorylationYSLYYPSSPLDAAGK
CCEECCCCCCCCCCC		25.6129514104
677PhosphorylationPLDAAGKSDPESVDK
CCCCCCCCCHHHHHH		58.4426370283
733PhosphorylationGFRNYNTSVDVRRHE
CCCCCCCCCEEEHHH		16.8123684622
771PhosphorylationSCRSTPLTLEISPDN
CCCCCCEEEEECCCC		24.4529550500
775PhosphorylationTPLTLEISPDNSLRR
CCEEEEECCCCCCCH		19.4728507225
779PhosphorylationLEISPDNSLRRVAEG
EEECCCCCCCHHHCC		30.5429550500
801PhosphorylationNIEAYRPSPKNLLAI
CEEEECCCCCCEEEE		39.2425338131
840PhosphorylationEIKERRGSDGSRSPT
HHHHHCCCCCCCCCC		36.6724899341
843PhosphorylationERRGSDGSRSPTASP
HHCCCCCCCCCCCCC		34.2826824392
845PhosphorylationRGSDGSRSPTASPKL
CCCCCCCCCCCCCCC		28.4424899341
847PhosphorylationSDGSRSPTASPKLGN
CCCCCCCCCCCCCCC		40.8023684622
849PhosphorylationGSRSPTASPKLGNAY
CCCCCCCCCCCCCCC		25.6624899341
856PhosphorylationSPKLGNAYLPSYHHS
CCCCCCCCCCCCCCC		24.1229514104
860PhosphorylationGNAYLPSYHHSPYKH
CCCCCCCCCCCCCCC		11.1229514104
863PhosphorylationYLPSYHHSPYKHAHI
CCCCCCCCCCCCCCC		19.33-
865PhosphorylationPSYHHSPYKHAHIPA
CCCCCCCCCCCCCCH		20.5829514104
879PhosphorylationAHAQHYQSYMHLIQQ
HHHHHHHHHHHHHHH		19.77-
908PhosphorylationSMCKDLNSSNSVEPR
HHHHCCCCCCCCCCC		37.8924759943
909PhosphorylationMCKDLNSSNSVEPRM
HHHCCCCCCCCCCCC		31.8624759943
911PhosphorylationKDLNSSNSVEPRMEW
HCCCCCCCCCCCCEE		29.7924759943
955PhosphorylationREERSGLTTDDDAMS
HHHHCCCCCCHHHHH		31.5323608596
956PhosphorylationEERSGLTTDDDAMSE
HHHCCCCCCHHHHHH		42.3423608596
962PhosphorylationTTDDDAMSEMKMGRY
CCCHHHHHHHHHHCC		35.94-
1025AcetylationSHKKMMKKRNKKIFD
HHHHHHHHHCHHHHH		43.226569563
1047PhosphorylationLLTHGTKSPDGTRVY
HHHCCCCCCCCCEEE		28.2325338131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PZRN3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PZRN3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PZRN3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PZRN3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PZRN3_MOUSE

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Related Literatures of Post-Translational Modification

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