dbPTM

SCML2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SCML2_HUMAN
UniProt AC	Q9UQR0
Protein Name	Sex comb on midleg-like protein 2
Gene Name	SCML2
Organism	Homo sapiens (Human).
Sequence Length	700
Subcellular Localization	Nucleus .
Protein Description	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)..
Protein Sequence	MGQTVNEDSMDVKKENQEKTPQSSTSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTSVPIVKNIAKTESSPSEASQHSMQSPQKTTLILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNSGKKEKPLPVICSTSAASLKSLTRDRGMLYKDVASGPCKIVMSTVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNRGGEVITASFDGETHSIQLPPVNSASFALRFLENFCHSLQCDNLLSSQPFSSSRGHTHSSAEHDKNQSAKEDVTERQSTKRSPQQTVPYVVPLSPKLPKTKEYASEGEPLFAGGSAIPKEENLSEDSKSSSLNSGNYLNPACRNPMYIHTSVSQDFSRSVPGTTSSPLVGDISPKSSPHEVKFQMQRKSEAPSYIAVPDPSVLKQGFSKDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKEGKYS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GQTVNEDSMDVKKEN CCCCCCCCCCCHHHH	15.65	21815630
10	Sulfoxidation	QTVNEDSMDVKKENQ CCCCCCCCCCHHHHH	12.12	21406390
13	Sumoylation	NEDSMDVKKENQEKT CCCCCCCHHHHHCCC	50.54	-
13	Sumoylation	NEDSMDVKKENQEKT CCCCCCCHHHHHCCC	50.54	-
13	Ubiquitination	NEDSMDVKKENQEKT CCCCCCCHHHHHCCC	50.54	32015554
19	Ubiquitination	VKKENQEKTPQSSTS CHHHHHCCCCCCCCC	56.60	29967540
20	Phosphorylation	KKENQEKTPQSSTSS HHHHHCCCCCCCCCC	26.30	21815630
23	Phosphorylation	NQEKTPQSSTSSVQR HHCCCCCCCCCCHHH	36.47	29449344
32	Ubiquitination	TSSVQRDDFHWEEYL CCCHHHCCCCHHHHH	39.23	24816145
40	Ubiquitination	FHWEEYLKETGSISA CCHHHHHHHHCCCCC	52.94	29967540
64	Ubiquitination	IPPVNDFKVGMKLEA CCCCCCCCCCEEEEE	40.52	29967540
68	Ubiquitination	NDFKVGMKLEARDPR CCCCCCEEEEECCCC	36.93	-
123	Methylation	QPVGTCEKEGDLLQP CCCCCCCCCCCCCCC	69.97	23583077
148	Phosphorylation	WPMFLLKTLNGSEMA CCEEEEHHCCCCCCC	25.98	22210691
152	Phosphorylation	LLKTLNGSEMASATL EEHHCCCCCCCCCCC	24.11	22210691
161	Sumoylation	MASATLFKKEPPKPP CCCCCCCCCCCCCCC	60.38	-
161	Sumoylation	MASATLFKKEPPKPP CCCCCCCCCCCCCCC	60.38	-
162	Ubiquitination	ASATLFKKEPPKPPL CCCCCCCCCCCCCCC	69.03	29967540
166	Ubiquitination	LFKKEPPKPPLNNFK CCCCCCCCCCCCCCC	70.72	29967540
173	Ubiquitination	KPPLNNFKVGMKLEA CCCCCCCCCEEEEEE	39.75	29967540
177	Sumoylation	NNFKVGMKLEAIDKK CCCCCEEEEEECCCC	36.93	-
177	Sumoylation	NNFKVGMKLEAIDKK CCCCCEEEEEECCCC	36.93	-
177	Ubiquitination	NNFKVGMKLEAIDKK CCCCCEEEEEECCCC	36.93	29967540
184	Sumoylation	KLEAIDKKNPYLICP EEEECCCCCCEEECC	60.45	-
184	Sumoylation	KLEAIDKKNPYLICP EEEECCCCCCEEECC	60.45	-
184	Ubiquitination	KLEAIDKKNPYLICP EEEECCCCCCEEECC	60.45	29967540
248	Ubiquitination	GTSVPIVKNIAKTES CCCCCEEEEEECCCC	43.27	29967540
252	Sumoylation	PIVKNIAKTESSPSE CEEEEEECCCCCHHH	49.37	-
252	Sumoylation	PIVKNIAKTESSPSE CEEEEEECCCCCHHH	49.37	-
253	Phosphorylation	IVKNIAKTESSPSEA EEEEEECCCCCHHHH	31.88	21712546
255	Phosphorylation	KNIAKTESSPSEASQ EEEECCCCCHHHHHH	53.43	25159151
256	Phosphorylation	NIAKTESSPSEASQH EEECCCCCHHHHHHH	26.64	23401153
258	Phosphorylation	AKTESSPSEASQHSM ECCCCCHHHHHHHCC	47.98	23401153
261	Phosphorylation	ESSPSEASQHSMQSP CCCHHHHHHHCCCCC	25.11	25159151
264	Phosphorylation	PSEASQHSMQSPQKT HHHHHHHCCCCCCCE	15.75	23401153
267	Phosphorylation	ASQHSMQSPQKTTLI HHHHCCCCCCCEEEE	22.21	25159151
271	Phosphorylation	SMQSPQKTTLILPTQ CCCCCCCEEEEEECH	22.91	27174698
272	Phosphorylation	MQSPQKTTLILPTQQ CCCCCCEEEEEECHH	20.88	27174698
277	Phosphorylation	KTTLILPTQQVRRSS CEEEEEECHHHHHHC	28.34	27174698
283	Phosphorylation	PTQQVRRSSRIKPPG ECHHHHHHCCCCCCC	17.26	29396449
284	Phosphorylation	TQQVRRSSRIKPPGP CHHHHHHCCCCCCCC	35.89	29396449
292	Phosphorylation	RIKPPGPTAVPKRSS CCCCCCCCCCCCCCC	46.32	29396449
296	Acetylation	PGPTAVPKRSSSVKN CCCCCCCCCCCCCCC	59.31	7707299
296	Ubiquitination	PGPTAVPKRSSSVKN CCCCCCCCCCCCCCC	59.31	24816145
298	Phosphorylation	PTAVPKRSSSVKNIT CCCCCCCCCCCCCCC	32.84	26434776
299	Phosphorylation	TAVPKRSSSVKNITP CCCCCCCCCCCCCCC	43.09	18669648
300	Phosphorylation	AVPKRSSSVKNITPR CCCCCCCCCCCCCCC	38.05	23401153
302	Ubiquitination	PKRSSSVKNITPRKK CCCCCCCCCCCCCCC	44.58	29967540
305	Phosphorylation	SSSVKNITPRKKGPN CCCCCCCCCCCCCCC	26.83	23401153
318	Sumoylation	PNSGKKEKPLPVICS CCCCCCCCCCCEEEC	61.81	-
318	Acetylation	PNSGKKEKPLPVICS CCCCCCCCCCCEEEC	61.81	25953088
318	Sumoylation	PNSGKKEKPLPVICS CCCCCCCCCCCEEEC	61.81	-
326	Phosphorylation	PLPVICSTSAASLKS CCCEEECCCCHHHHH	20.27	19413330
332	Acetylation	STSAASLKSLTRDRG CCCCHHHHHHHCCCC	40.71	25953088
332	Ubiquitination	STSAASLKSLTRDRG CCCCHHHHHHHCCCC	40.71	32015554
333	Phosphorylation	TSAASLKSLTRDRGM CCCHHHHHHHCCCCC	40.02	20068231
335	Phosphorylation	AASLKSLTRDRGMLY CHHHHHHHCCCCCCH	37.30	20068231
343	Ubiquitination	RDRGMLYKDVASGPC CCCCCCHHHHCCCCC	41.59	29967540
374	Ubiquitination	FGPHLDPKRIQQLPD CCCCCCHHHHHHCCC	62.90	29967540
407	Acetylation	VDCALETKTVFGYLK HHHHHHCCEEEEEEC	33.06	7987909
482	Acetylation	HSSAEHDKNQSAKED CCCHHHCCCCCHHHH	59.81	18526221
487	Sumoylation	HDKNQSAKEDVTERQ HCCCCCHHHHHHHHH	60.74	-
487	Sumoylation	HDKNQSAKEDVTERQ HCCCCCHHHHHHHHH	60.74	-
495	Phosphorylation	EDVTERQSTKRSPQQ HHHHHHHHCCCCCCC	41.96	23927012
496	Phosphorylation	DVTERQSTKRSPQQT HHHHHHHCCCCCCCC	23.34	23927012
499	Phosphorylation	ERQSTKRSPQQTVPY HHHHCCCCCCCCCCE	28.72	22167270
503	Phosphorylation	TKRSPQQTVPYVVPL CCCCCCCCCCEEEEC	20.43	22167270
506	Phosphorylation	SPQQTVPYVVPLSPK CCCCCCCEEEECCCC	15.11	30266825
511	Phosphorylation	VPYVVPLSPKLPKTK CCEEEECCCCCCCCH	17.58	25159151
517	Phosphorylation	LSPKLPKTKEYASEG CCCCCCCCHHHHCCC	27.46	26074081
518	Sumoylation	SPKLPKTKEYASEGE CCCCCCCHHHHCCCC	55.65	28112733
518	Ubiquitination	SPKLPKTKEYASEGE CCCCCCCHHHHCCCC	55.65	29967540
520	Phosphorylation	KLPKTKEYASEGEPL CCCCCHHHHCCCCCC	19.58	26074081
522	Phosphorylation	PKTKEYASEGEPLFA CCCHHHHCCCCCCCC	45.28	21815630
536	Sumoylation	AGGSAIPKEENLSED CCCCCCCCCCCCCCC	72.11	-
536	Sumoylation	AGGSAIPKEENLSED CCCCCCCCCCCCCCC	72.11	28112733
536	Ubiquitination	AGGSAIPKEENLSED CCCCCCCCCCCCCCC	72.11	29967540
544	Phosphorylation	EENLSEDSKSSSLNS CCCCCCCCCCCCCCC	30.31	20068231
545	Sumoylation	ENLSEDSKSSSLNSG CCCCCCCCCCCCCCC	67.68	-
545	Sumoylation	ENLSEDSKSSSLNSG CCCCCCCCCCCCCCC	67.68	-
545	Ubiquitination	ENLSEDSKSSSLNSG CCCCCCCCCCCCCCC	67.68	32015554
546	Phosphorylation	NLSEDSKSSSLNSGN CCCCCCCCCCCCCCC	29.16	25627689
547	Phosphorylation	LSEDSKSSSLNSGNY CCCCCCCCCCCCCCC	42.45	25627689
548	Phosphorylation	SEDSKSSSLNSGNYL CCCCCCCCCCCCCCC	38.37	25627689
551	Phosphorylation	SKSSSLNSGNYLNPA CCCCCCCCCCCCCHH	33.44	28555341
564	Phosphorylation	PACRNPMYIHTSVSQ HHHCCCEEEEEECCC	7.27	29978859
567	Phosphorylation	RNPMYIHTSVSQDFS CCCEEEEEECCCCCC	22.67	29978859
568	O-linked_Glycosylation	NPMYIHTSVSQDFSR CCEEEEEECCCCCCC	12.95	30059200
568	Phosphorylation	NPMYIHTSVSQDFSR CCEEEEEECCCCCCC	12.95	28450419
570	O-linked_Glycosylation	MYIHTSVSQDFSRSV EEEEEECCCCCCCCC	24.65	30059200
570	Phosphorylation	MYIHTSVSQDFSRSV EEEEEECCCCCCCCC	24.65	17525332
574	Phosphorylation	TSVSQDFSRSVPGTT EECCCCCCCCCCCCC	31.75	28450419
576	Phosphorylation	VSQDFSRSVPGTTSS CCCCCCCCCCCCCCC	31.31	21712546
580	Phosphorylation	FSRSVPGTTSSPLVG CCCCCCCCCCCCCCC	19.89	21712546
581	Phosphorylation	SRSVPGTTSSPLVGD CCCCCCCCCCCCCCC	32.87	21712546
582	Phosphorylation	RSVPGTTSSPLVGDI CCCCCCCCCCCCCCC	29.78	25159151
583	Phosphorylation	SVPGTTSSPLVGDIS CCCCCCCCCCCCCCC	21.84	23401153
590	Phosphorylation	SPLVGDISPKSSPHE CCCCCCCCCCCCCCC	30.89	29255136
593	Phosphorylation	VGDISPKSSPHEVKF CCCCCCCCCCCCCEE	53.11	27362937
594	Phosphorylation	GDISPKSSPHEVKFQ CCCCCCCCCCCCEEE	36.08	27362937
599	Sumoylation	KSSPHEVKFQMQRKS CCCCCCCEEEEECCC	27.22	-
599	Acetylation	KSSPHEVKFQMQRKS CCCCCCCEEEEECCC	27.22	26051181
599	Sumoylation	KSSPHEVKFQMQRKS CCCCCCCEEEEECCC	27.22	28112733
599	Ubiquitination	KSSPHEVKFQMQRKS CCCCCCCEEEEECCC	27.22	32015554
605	Sumoylation	VKFQMQRKSEAPSYI CEEEEECCCCCCCEE	35.44	-
605	Sumoylation	VKFQMQRKSEAPSYI CEEEEECCCCCCCEE	35.44	28112733
605	Ubiquitination	VKFQMQRKSEAPSYI CEEEEECCCCCCCEE	35.44	29967540
606	Phosphorylation	KFQMQRKSEAPSYIA EEEEECCCCCCCEEE	40.97	25159151
610	Phosphorylation	QRKSEAPSYIAVPDP ECCCCCCCEEECCCH	35.90	29449344
611	Phosphorylation	RKSEAPSYIAVPDPS CCCCCCCEEECCCHH	7.58	27642862
621	Sumoylation	VPDPSVLKQGFSKDP CCCHHHHHCCCCCCC	46.34	-
621	Ubiquitination	VPDPSVLKQGFSKDP CCCHHHHHCCCCCCC	46.34	29967540
663	Ubiquitination	RQHEIDGKALFLLKS HHCCCCCEEEEEECH	37.86	29967540
670	Phosphorylation	KALFLLKSDVMMKYM EEEEEECHHHHHHHC	35.09	21406692
680	Sumoylation	MMKYMGLKLGPALKL HHHHCCCCHHHHHHH	45.74	-
680	Sumoylation	MMKYMGLKLGPALKL HHHHCCCCHHHHHHH	45.74	-
693	Acetylation	KLCYYIEKLKEGKYS HHHHHHHHHHCCCCC	56.13	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
267	S	Phosphorylation	Kinase	CDK1	P06493	PSP
267	S	Phosphorylation	Kinase	CDK2	P24941	PSP
305	T	Phosphorylation	Kinase	CDK1	P06493	PSP
305	T	Phosphorylation	Kinase	CDK2	P24941	PSP
511	S	Phosphorylation	Kinase	CDK1	P06493	PSP
511	S	Phosphorylation	Kinase	CDK2	P24941	PSP
590	S	Phosphorylation	Kinase	CDK1	P06493	PSP
590	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SCML2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SCML2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
BAG1_HUMAN	BAG1	physical	26344197
UBP7_HUMAN	USP7	physical	25605328

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SCML2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499; TYR-506; SER-511AND SER-590, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-253; SER-255; SER-267;SER-499; THR-503; TYR-506; SER-511; SER-582; SER-583 AND SER-590, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256; SER-258; SER-267;SER-299; SER-300; THR-305; SER-499; THR-503; SER-511; SER-576;SER-583; SER-590 AND SER-594, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, AND MASSSPECTROMETRY.	17525332 [Abstract]