| UniProt ID | ARHG3_HUMAN | |
|---|---|---|
| UniProt AC | Q9NR81 | |
| Protein Name | Rho guanine nucleotide exchange factor 3 | |
| Gene Name | ARHGEF3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 526 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.. | |
| Protein Sequence | MVAKDYPFYLTVKRANCSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 (in isoform 2) | Phosphorylation | - | 59.26 | 25627689 | |
| 43 | Phosphorylation | NKRVKPLSRVTSLAN CCCCCCHHHHHHHHH | 32.98 | - | |
| 46 | Phosphorylation | VKPLSRVTSLANLIP CCCHHHHHHHHHHCC | 19.53 | 23403867 | |
| 47 | Phosphorylation | KPLSRVTSLANLIPP CCHHHHHHHHHHCCC | 23.72 | 23403867 | |
| 49 (in isoform 2) | Phosphorylation | - | 14.46 | 29116813 | |
| 50 (in isoform 2) | Phosphorylation | - | 43.74 | 25394399 | |
| 56 | Ubiquitination | ANLIPPVKATPLKRF HHHCCCCCCCCHHHH | 52.93 | - | |
| 57 (in isoform 2) | Phosphorylation | - | 18.06 | 20873877 | |
| 60 (in isoform 2) | Phosphorylation | - | 5.59 | 20873877 | |
| 64 | Phosphorylation | ATPLKRFSQTLQRSI CCCHHHHHHHHHHHH | 26.70 | 28857561 | |
| 70 | Phosphorylation | FSQTLQRSISFRSES HHHHHHHHHCCCCCC | 15.04 | 22210691 | |
| 72 | Phosphorylation | QTLQRSISFRSESRP HHHHHHHCCCCCCCC | 18.82 | 24719451 | |
| 79 (in isoform 2) | Phosphorylation | - | 42.12 | 24719451 | |
| 96 (in isoform 2) | Phosphorylation | - | 32.67 | 27251275 | |
| 104 (in isoform 2) | Phosphorylation | - | 9.62 | 24719451 | |
| 146 | Ubiquitination | EDLKLAKKAYHDPML HHHHHHHHHHCCCCH | 48.87 | - | |
| 249 | Ubiquitination | LESPFSRKLDLWNFL HCCCCCCCCCHHHHH | 45.19 | - | |
| 265 | Ubiquitination | IPRSRLVKYPLLLRE CCHHHHCHHHHHHHH | 45.82 | - | |
| 281 (in isoform 2) | Ubiquitination | - | 49.00 | - | |
| 297 (in isoform 2) | Ubiquitination | - | 1.20 | - | |
| 325 | Ubiquitination | LYLEEGQKDSLIDSS EECCCCCCCCCCCCC | 61.21 | - | |
| 342 | Ubiquitination | LCCHGELKNNRGVKL EEEECCCCCCCCCEE | 48.12 | - | |
| 374 (in isoform 2) | Ubiquitination | - | 1.21 | - | |
| 382 | Ubiquitination | YRQPIPVKDLLLEDL HCCCCCHHHHHEHHH | 36.99 | - | |
| 399 | Phosphorylation | GEVRLGGSLRGAFSN CCEECCCCCCCCCCC | 17.07 | 25159151 | |
| 411 | Ubiquitination | FSNNERIKNFFRVSF CCCCHHHHHEEEEEE | 54.65 | - | |
| 414 (in isoform 2) | Ubiquitination | - | 12.02 | - | |
| 417 | Phosphorylation | IKNFFRVSFKNGSQS HHHEEEEEECCCCCC | 26.67 | 29496963 | |
| 419 | Ubiquitination | NFFRVSFKNGSQSQT HEEEEEECCCCCCCC | 53.55 | - | |
| 431 (in isoform 2) | Phosphorylation | - | 22.59 | 24719451 | |
| 437 | Ubiquitination | QANDTFNKQQWLNCI ECCCCCCHHHHHHHH | 39.41 | - | |
| 443 (in isoform 2) | Ubiquitination | - | 2.25 | - | |
| 451 (in isoform 2) | Ubiquitination | - | 4.30 | - | |
| 466 | Phosphorylation | GVLDSEGSFLNPTTG CCCCCCCCCCCCCCC | 23.62 | - | |
| 489 | Phosphorylation | KLEQMDQSDSESDCS HHHHCCCCCCCCCCC | 38.55 | 30576142 | |
| 491 | Phosphorylation | EQMDQSDSESDCSMD HHCCCCCCCCCCCCC | 44.22 | 30576142 | |
| 493 | Phosphorylation | MDQSDSESDCSMDTS CCCCCCCCCCCCCHH | 48.12 | 30576142 | |
| 499 | Phosphorylation | ESDCSMDTSEVSLDC CCCCCCCHHHCCEEC | 20.39 | 30576142 | |
| 503 | Phosphorylation | SMDTSEVSLDCERME CCCHHHCCEECHHHH | 17.90 | 30576142 | |
| 524 | Phosphorylation | GNSRHGESNV----- CCCCCCCCCC----- | 47.70 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ARHG3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ARHG3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ARHG3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RHOA_HUMAN | RHOA | physical | 12221096 | |
| RHOB_HUMAN | RHOB | physical | 12221096 | |
| CEP70_HUMAN | CEP70 | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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