WDR25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR25_HUMAN
• UniProt AC: Q64LD2
• Protein Name: WD repeat-containing protein 25
• Gene Name: WDR25 {ECO:0000312|HGNC:HGNC:21064}
• Organism: Homo sapiens (Human).
• Sequence Length: 544
• Protein Sequence: MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKAGAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTSHVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRRLRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDMKIWH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	TGQQKDTSGVARPPG CCCCCCCCCCCCCCC	41.21	28555341
69	Phosphorylation	AQPTKHGSCEDPGGY CCCCCCCCCCCCCCC	17.66	28555341
146	Phosphorylation	LSRNFPKSSFHAQSE ECCCCCCHHCEEECC	38.17	-
159	Methylation	SESETVGKNGSSFQK CCCCCCCCCCCCCCC	54.52	115978681
167	Methylation	NGSSFQKKKCEDCVV CCCCCCCCCCCCCCC	52.45	115978689
176	Phosphorylation	CEDCVVPYTPRRLRQ CCCCCCCCCHHHHHH	20.12	28555341
177	Phosphorylation	EDCVVPYTPRRLRQR CCCCCCCCHHHHHHH	12.30	21815630
188	Phosphorylation	LRQRQALSTETGKGK HHHHHCCCCCCCCCC	27.49	29978859
189	Phosphorylation	RQRQALSTETGKGKD HHHHCCCCCCCCCCC	38.11	29978859
191	Phosphorylation	RQALSTETGKGKDVE HHCCCCCCCCCCCCC	44.26	29978859
193	Ubiquitination	ALSTETGKGKDVEPQ CCCCCCCCCCCCCCC	70.93	-
232	Phosphorylation	LNSHYKETTVPRKVL HHHCCCCCCCCHHHH	29.01	-
233	Phosphorylation	NSHYKETTVPRKVLF HHCCCCCCCCHHHHH	29.60	-
237	Ubiquitination	KETTVPRKVLFHLRG CCCCCCHHHHHHCCC	36.90	-
329	Phosphorylation	ETGTQLFSGRSDFRI CCCCEEECCCCCEEE	41.72	24719451
389	Phosphorylation	ILFLREGSEFLSSTD EEEECCCCHHHCCCC	22.03	-
393	Phosphorylation	REGSEFLSSTDASTR CCCCHHHCCCCCCCC	36.19	-
394	Phosphorylation	EGSEFLSSTDASTRD CCCHHHCCCCCCCCC	32.24	-
459	Phosphorylation	LFSTVWPYRMSRRRR EEEEEHHHHCCCCCC	11.84	17053785
475	Phosphorylation	EGHKVEGYSVGCECS CCCCCCCEEEECEEC	6.15	-
482	Phosphorylation	YSVGCECSPGGDLLV EEEECEECCCCCEEE	12.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR25_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
TCPH_HUMAN	CCT7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling.";
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.;
EMBO J. 25:5058-5070(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-459, AND MASSSPECTROMETRY.
PubMed: 17053785