TXND3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXND3_HUMAN
• UniProt AC: Q8N427
• Protein Name: Thioredoxin domain-containing protein 3
• Gene Name: NME8
• Organism: Homo sapiens (Human).
• Sequence Length: 588
• Subcellular Localization: Cytoplasm .
• Protein Description: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds..
• Protein Sequence: MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKIAAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEETEPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFMDAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Methylation	TLQPFRDKCEPVFLF EEECCCCCCCEEEEE	35.92	23644510
237	Phosphorylation	GSKHNPPSEETEPQT CCCCCCCCCCCCCCC	49.69	25693802
240	Phosphorylation	HNPPSEETEPQTDTE CCCCCCCCCCCCCCC	49.25	25693802
244	Phosphorylation	SEETEPQTDTEPNER CCCCCCCCCCCCCCC	56.45	25693802
246	Phosphorylation	ETEPQTDTEPNERSE CCCCCCCCCCCCCCC	57.65	25693802
252	Phosphorylation	DTEPNERSEDQPEVE CCCCCCCCCCCHHHH	39.07	25693802
273	Phosphorylation	MMKNKQDSLQEYLER HHCCCHHHHHHHHHH	29.47	30622161
277	Phosphorylation	KQDSLQEYLERQHLA CHHHHHHHHHHHHHH	10.82	30622161
308	Acetylation	DAFFPDFKKMKSMKL HHHCCCHHHHHHCCH	60.38	25038526
356	Acetylation	RQVVLSEKEAQALCK HHHHCCHHHHHHHHH	55.78	25038526
405	Phosphorylation	KQLLGPRTVEEAIEY HHHHCCCCHHHHHHH	35.09	-
481	Phosphorylation	KEAGFDLTQVKKMFL HHHCCCHHHHHHHCC	32.91	-
489	Phosphorylation	QVKKMFLTPEQIEKI HHHHHCCCHHHHHHH	17.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXND3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXND3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXND3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
IFT20_HUMAN	IFT20	physical	27173435
IFT57_HUMAN	IFT57	physical	27173435
MIPT3_HUMAN	TRAF3IP1	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.