STK19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STK19_HUMAN
• UniProt AC: P49842
• Protein Name: Serine/threonine-protein kinase 19
• Gene Name: STK19
• Organism: Homo sapiens (Human).
• Sequence Length: 368
• Subcellular Localization: Nucleus.
• Protein Description: Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues..
• Protein Sequence: MQKWFSAFDDAIIQRQWRANPSRGGGGVSFTKEVDTNVATGAPPRRQRVPGRACPWREPIRGRRGARPGGGDAGGTPGETVRHCSAPEDPIFRFSSLHSYPFPGTIKSRDMSWKRHHLIPETFGVKRRRKRGPVESDPLRGEPGSARAAVSELMQLFPRGLFEDALPPIVLRSQVYSLVPDRTVADRQLKELQEQGEIRIVQLGFDLDAHGIIFTEDYRTRVCDCVLKACDGRPYAGAVQKFLASVLPACGDLSFQQDQMTQTFGFRDSEITHLVNAGVLTVRDAGSWWLAVPGAGRFIKYFVKGRQAVLSMVRKAKYRELLLSELLGRRAPVVVRLGLTYHVHDLIGAQLVDCISTTSGTLLRLPET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	SRGGGGVSFTKEVDT CCCCCCCCCCEEECC	30.39	24719451
36	Phosphorylation	SFTKEVDTNVATGAP CCCEEECCCCCCCCC	36.45	23403867
95	Phosphorylation	EDPIFRFSSLHSYPF CCCCEECCCCCCCCC	27.95	26657352
105	Phosphorylation	HSYPFPGTIKSRDMS CCCCCCCCEECCCCC	26.01	30622161
108	Phosphorylation	PFPGTIKSRDMSWKR CCCCCEECCCCCCHH	29.66	30622161
112	Phosphorylation	TIKSRDMSWKRHHLI CEECCCCCCHHHHCC	33.46	30622161
136	Phosphorylation	RKRGPVESDPLRGEP CCCCCCCCCCCCCCC	44.77	-
311	Phosphorylation	KGRQAVLSMVRKAKY HHHHHHHHHHHHHHH	14.50	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STK19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STK19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STK19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPOE1_HUMAN	POLE	physical	14667819
RPB7_HUMAN	POLR2G	physical	14667819
S29A1_HUMAN	SLC29A1	physical	14667819
PRAME_HUMAN	PRAME	physical	14667819

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.