| UniProt ID | GEM_HUMAN | |
|---|---|---|
| UniProt AC | P55040 | |
| Protein Name | GTP-binding protein GEM | |
| Gene Name | GEM | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 296 | |
| Subcellular Localization |
Cell membrane Peripheral membrane protein Cytoplasmic side. |
|
| Protein Description | Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.. | |
| Protein Sequence | MTLNNVTMRQGTVGMQPQQQRWSIPADGRHLMVQKEPHQYSHRNRHSATPEDHCRRSWSSDSTDSVISSESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLMVDGESATIILLDMWENKGENEWLHDHCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQKRKESMPRKARRFWGKIVAKNNKNMAFKLKSKSCHDLSVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTLNNVTMR ------CCCCCEEEC | 37.89 | 22210691 | |
| 7 | Phosphorylation | -MTLNNVTMRQGTVG -CCCCCEEECCCCCC | 14.57 | 26552605 | |
| 12 | Phosphorylation | NVTMRQGTVGMQPQQ CEEECCCCCCCCCCC | 12.92 | 26552605 | |
| 23 | Phosphorylation | QPQQQRWSIPADGRH CCCCEEEECCCCCCE | 22.38 | 30266825 | |
| 47 | Phosphorylation | YSHRNRHSATPEDHC CCCCCCCCCCCHHHH | 30.51 | 27251275 | |
| 49 | Phosphorylation | HRNRHSATPEDHCRR CCCCCCCCCHHHHHC | 30.17 | 27251275 | |
| 57 | Phosphorylation | PEDHCRRSWSSDSTD CHHHHHCCCCCCCCC | 16.38 | 22777824 | |
| 59 | Phosphorylation | DHCRRSWSSDSTDSV HHHHCCCCCCCCCCE | 26.05 | 24114839 | |
| 60 | Phosphorylation | HCRRSWSSDSTDSVI HHHCCCCCCCCCCEE | 29.35 | 28985074 | |
| 181 | Phosphorylation | QLRRARQTEDIPIIL HHHHHHCCCCCCEEE | 30.03 | 23403867 | |
| 255 | Phosphorylation | KNERRLAYQKRKESM HHHHHHHHHHHHHHC | 21.11 | - | |
| 261 | Phosphorylation | AYQKRKESMPRKARR HHHHHHHHCCHHHHH | 36.80 | 22817900 | |
| 276 | Acetylation | FWGKIVAKNNKNMAF HHHHHEEECCCCCEE | 50.59 | 20167786 | |
| 279 | Acetylation | KIVAKNNKNMAFKLK HHEEECCCCCEEEEE | 58.45 | 20167786 | |
| 287 | Phosphorylation | NMAFKLKSKSCHDLS CCEEEEECCCCCCCC | 39.99 | 22617229 | |
| 289 | Phosphorylation | AFKLKSKSCHDLSVL EEEEECCCCCCCCCC | 24.63 | 30266825 | |
| 294 | Phosphorylation | SKSCHDLSVL----- CCCCCCCCCC----- | 27.68 | 30266825 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 261 | S | Phosphorylation | Kinase | PRKCZ | Q05513 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GEM_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GEM_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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