BMP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BMP1_HUMAN
• UniProt AC: P13497
• Protein Name: Bone morphogenetic protein 1
• Gene Name: BMP1
• Organism: Homo sapiens (Human).
• Sequence Length: 986
• Subcellular Localization: Golgi apparatus, trans-Golgi network . Secreted, extracellular space, extracellular matrix . Co-localizes with POSTN in the Golgi..
• Protein Description: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX..
• Protein Sequence: MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	LDLADYTYDLAEEDD CCHHHHEEECCCCCC	11.61	-
78	Phosphorylation	AVDLRRHTARKSSIK HHHHHHHHCCHHHCE	26.75	-
82	Phosphorylation	RRHTARKSSIKAAVP HHHHCCHHHCEEECC	31.57	-
91	N-linked_Glycosylation	IKAAVPGNTSTPSCQ CEEECCCCCCCCCCC	25.45	12218058
91	N-linked_Glycosylation	IKAAVPGNTSTPSCQ CEEECCCCCCCCCCC	25.45	12218058
142	N-linked_Glycosylation	IPFVIGGNFTGSQRA EEEEECCCCCHHHHH	26.54	12218058
142	N-linked_Glycosylation	IPFVIGGNFTGSQRA EEEEECCCCCHHHHH	26.54	12218058
285	Phosphorylation	SRGIFLDTIVPKYEV CCCEECCCCCCCCEE	26.48	24670416
307	Ubiquitination	GQRTRLSKGDIAQAR CCCCCCCCCCHHHHH	66.26	-
325	Phosphorylation	KCPACGETLQDSTGN CCCCCCCCCCCCCCC	18.27	22210691
332	N-linked_Glycosylation	TLQDSTGNFSSPEYP CCCCCCCCCCCCCCC	33.44	12218058
332	N-linked_Glycosylation	TLQDSTGNFSSPEYP CCCCCCCCCCCCCCC	33.44	12218058
342	Phosphorylation	SPEYPNGYSAHMHCV CCCCCCCCCCCEEEE	14.88	22210691
355	Phosphorylation	CVWRISVTPGEKIIL EEEEEEECCCCEEEE	20.84	22210691
363	N-linked_Glycosylation	PGEKIILNFTSLDLY CCCEEEEECCCHHHH	27.95	12218058
363	N-linked_Glycosylation	PGEKIILNFTSLDLY CCCEEEEECCCHHHH	27.95	12218058
377	Phosphorylation	YRSRLCWYDYVEVRD HHHCCCCCEEEEEEC	9.08	26657352
379	Phosphorylation	SRLCWYDYVEVRDGF HCCCCCEEEEEECCE	5.25	26657352
443	Phosphorylation	GGDVKKDYGHIQSPN CCCCCCCCCCCCCCC	21.34	22817900
451	Phosphorylation	GHIQSPNYPDDYRPS CCCCCCCCCCCCCCC	16.06	18083107
523	Phosphorylation	DDIKSTSSRLWLKFV CCCCCCCCEEEEEEE	31.33	-
599	N-linked_Glycosylation	GGFLTKLNGSITSPG HCHHHHCCCCCCCCC	43.66	12218058
599	N-linked_Glycosylation	GGFLTKLNGSITSPG HCHHHHCCCCCCCCC	43.66	12218058
753	Phosphorylation	GCDHKVTSTSGTITS CCCCCCEECCCCCCC	24.46	30576142
755	Phosphorylation	DHKVTSTSGTITSPN CCCCEECCCCCCCCC	33.43	30576142
769	Phosphorylation	NWPDKYPSKKECTWA CCCCCCCCCCCEEEE	53.95	30576142
843	Phosphorylation	RMFLRFYSDNSVQRK EEEEEECCCCCHHCC	27.83	-
855	Phosphorylation	QRKGFQASHATECGG HCCCEECCCHHHCCC	11.67	-
870	Phosphorylation	QVRADVKTKDLYSHA EEEEECCCCCCCCCC	29.64	-
934	Methylation	GYDSTAPRLGRYCGS CCCCCCCCHHCCCCC	47.51	-
937	Methylation	STAPRLGRYCGSGPP CCCCCHHCCCCCCCH	28.32	-
973	Phosphorylation	KKGFHLRYTSTKFQD CCEEEEEEEECCHHH	16.05	17081983
975	Phosphorylation	GFHLRYTSTKFQDTL EEEEEEEECCHHHHH	22.21	17081983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BMP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BMP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BMP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHRD_HUMAN	CHRD	physical	11260715
TLL2_HUMAN	TLL2	physical	28514442
TLL1_HUMAN	TLL1	physical	28514442
CLIP1_HUMAN	CLIP1	physical	28514442
RMD5B_HUMAN	RMND5B	physical	28514442
NBN_HUMAN	NBN	physical	28514442
GOGA4_HUMAN	GOLGA4	physical	28514442
KIF2C_HUMAN	KIF2C	physical	28514442
GID4_HUMAN	GID4	physical	28514442
MRE11_HUMAN	MRE11A	physical	28514442
CSTF3_HUMAN	CSTF3	physical	28514442
MD1L1_HUMAN	MAD1L1	physical	28514442
WDR26_HUMAN	WDR26	physical	28514442
ARMC8_HUMAN	ARMC8	physical	28514442
RAD50_HUMAN	RAD50	physical	28514442
MKLN1_HUMAN	MKLN1	physical	28514442
CND3_HUMAN	NCAPG	physical	28514442
RMD5A_HUMAN	RMND5A	physical	28514442
CND1_HUMAN	NCAPD2	physical	28514442
GID8_HUMAN	GID8	physical	28514442
KIF5A_HUMAN	KIF5A	physical	28514442
MAEA_HUMAN	MAEA	physical	28514442
KAPCB_HUMAN	PRKACB	physical	28514442
RBP10_HUMAN	RANBP10	physical	28514442
EEA1_HUMAN	EEA1	physical	28514442
RAD21_HUMAN	RAD21	physical	28514442
ZMY19_HUMAN	ZMYND19	physical	28514442
CSTF1_HUMAN	CSTF1	physical	28514442
KDEL1_HUMAN	KDELC1	physical	28514442
SMC2_HUMAN	SMC2	physical	28514442
SDF2L_HUMAN	SDF2L1	physical	28514442
RANB9_HUMAN	RANBP9	physical	28514442
KDEL2_HUMAN	KDELC2	physical	28514442
AINX_HUMAN	INA	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614856: Osteogenesis imperfecta 13 (OI13)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.