TLL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLL2_HUMAN
• UniProt AC: Q9Y6L7
• Protein Name: Tolloid-like protein 2
• Gene Name: TLL2
• Organism: Homo sapiens (Human).
• Sequence Length: 1015
• Subcellular Localization: Secreted .
• Protein Description: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis..
• Protein Sequence: MPRATALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEGTEQQLEHYHDPCKAAVFWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQDALHMKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	ARDWTKQTVGATGHS CCCCCCCCCCCCCCC	23.59	-
116	Phosphorylation	TTAMDTGTKEAGKDG CCCCCCCCCCCCCCC	28.01	-
144	Phosphorylation	HAAAKTFSPRVRRAT HHHHHHCCHHHHHCC	19.61	24719451
155	Phosphorylation	RRATTSRTERIWPGG HHCCCCCCCCCCCCC	29.41	24719451
171	N-linked_Glycosylation	IPYVIGGNFTGSQRA ECEEECCCCCHHHHH	26.54	UniProtKB CARBOHYD
327	O-linked_Glycosylation	DDNGVRPTIGQRVRL CCCCCCCCCCCEEEC	27.46	55830703
361	N-linked_Glycosylation	TLQDTTGNFSAPGFP CCCCCCCCCCCCCCC	26.13	UniProtKB CARBOHYD
392	N-linked_Glycosylation	PGEKIVLNFTSMDLF CCCEEEEEEECHHHH	27.53	UniProtKB CARBOHYD
406	Phosphorylation	FKSRLCWYDYVEVRD HHHCCCCCEEEEEEC	9.08	26657352
408	Phosphorylation	SRLCWYDYVEVRDGY HCCCCCEEEEEECCE	5.25	26657352
447	Phosphorylation	RLWVEFRSSSNILGK EEEEEEECCCCCCCC	43.36	22468782
448	Phosphorylation	LWVEFRSSSNILGKG EEEEEECCCCCCCCC	24.13	22468782
449	Phosphorylation	WVEFRSSSNILGKGF EEEEECCCCCCCCCE	29.18	22468782
613	Ubiquitination	GYELAADKKMCEVAC CCHHHCCCCEEEHHH	37.37	29967540
628	N-linked_Glycosylation	GGFITKLNGTITSPG CCEEEEECCCCCCCC	47.30	UniProtKB CARBOHYD
716	Phosphorylation	NMRVEFKSDNTVSKR CEEEEEECCCCCCCC	41.22	-
719	Phosphorylation	VEFKSDNTVSKRGFR EEEECCCCCCCCCEE	31.02	-
781	Phosphorylation	AGCAHKISSVEGTLA CCCCEECCCCCCCCC	32.89	26852163
782	Phosphorylation	GCAHKISSVEGTLAS CCCEECCCCCCCCCC	27.88	26852163
786	Phosphorylation	KISSVEGTLASPNWP ECCCCCCCCCCCCCC	12.97	26852163
789	Phosphorylation	SVEGTLASPNWPDKY CCCCCCCCCCCCCCC	23.14	26852163
796	Phosphorylation	SPNWPDKYPSRRECT CCCCCCCCCCCCEEE	17.51	27251275
798	Phosphorylation	NWPDKYPSRRECTWN CCCCCCCCCCEEEEE	40.66	27251275
805	N-linked_Glycosylation	SRRECTWNISSTAGH CCCEEEEEECCCCCC	13.20	UniProtKB CARBOHYD
899	Phosphorylation	RLKAEVQTKELYSHA EEEEEEEHHHHHHCC	31.49	-
963	Methylation	GYDSSAPRLGRFCGS CCCCCCCCHHCCCCC	49.87	-
966	Methylation	SSAPRLGRFCGSGPL CCCCCHHCCCCCCCH	28.42	-
978	Phosphorylation	GPLEEIYSAGDSLMI CCHHHHHCCCCEEEE	31.28	24719451
989	Phosphorylation	SLMIRFRTDDTINKK EEEEEEECCCCCCCC	35.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLL2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TLL2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.