TLL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLL1_HUMAN
• UniProt AC: O43897
• Protein Name: Tolloid-like protein 1
• Gene Name: TLL1
• Organism: Homo sapiens (Human).
• Sequence Length: 1013
• Subcellular Localization: Secreted .
• Protein Description: Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis..
• Protein Sequence: MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGLGTLSPRMLV ---CCCCCCCHHHHH	29.16	27732954
7	Phosphorylation	-MGLGTLSPRMLVWL -CCCCCCCHHHHHHH	15.42	24505115
45	Phosphorylation	DGNEEDKTETIDYKD CCCCCCCCEEECCCC	51.16	26074081
47	Phosphorylation	NEEDKTETIDYKDPC CCCCCCEEECCCCCC	25.12	26074081
50	Phosphorylation	DKTETIDYKDPCKAA CCCEEECCCCCCEEE	17.28	26074081
109	Phosphorylation	SKKRGALYQLIDRIR HHHHCHHHHHHHHHH	10.76	24670416
131	Ubiquitination	QNNTVKGKVPLQFSG CCCCCCEECCCEECC	34.65	-
150	Phosphorylation	NRVPRAATSRTERIW CCCCCCCCCCCCCCC	20.11	20363803
151	Phosphorylation	RVPRAATSRTERIWP CCCCCCCCCCCCCCC	32.26	20363803
153	Phosphorylation	PRAATSRTERIWPGG CCCCCCCCCCCCCCC	29.41	24719451
169	N-linked_Glycosylation	IPYVIGGNFTGSQRA ECEEECCCCCHHHHH	26.54	UniProtKB CARBOHYD
303	Phosphorylation	IMHYARNTFSRGMFL HHHHHHHHCCCCCCH	19.89	30257219
312	Phosphorylation	SRGMFLDTILPSRDD CCCCCHHHCCCCCCC	26.93	22210691
334	Ubiquitination	GQRTRLSKGDIAQAR CCCCCCCCCCHHHHH	66.26	-
359	N-linked_Glycosylation	TLQESNGNLSSPGFP CHHHCCCCCCCCCCC	40.79	UniProtKB CARBOHYD
390	N-linked_Glycosylation	PGEKIVLNFTTMDLY CCCEEEEEEECHHHH	22.71	UniProtKB CARBOHYD
399	Phosphorylation	TTMDLYKSSLCWYDY ECHHHHHCCCCCEEE	18.26	26074081
400	Phosphorylation	TMDLYKSSLCWYDYI CHHHHHCCCCCEEEE	24.32	26074081
404	Phosphorylation	YKSSLCWYDYIEVRD HHCCCCCEEEEEEEC	9.62	26074081
406	Phosphorylation	SSLCWYDYIEVRDGY CCCCCEEEEEEECCE	5.36	26074081
413	Phosphorylation	YIEVRDGYWRKSPLL EEEEECCEEECCCHH	13.31	26074081
417	Phosphorylation	RDGYWRKSPLLGRFC ECCEEECCCHHHCCC	16.53	26074081
478	Phosphorylation	GQIQSPNYPDDYRPM CCCCCCCCCCCCCCH	16.06	22817900
626	N-linked_Glycosylation	GGLLTKLNGTITTPG HHHHHCCCCEECCCC	47.30	UniProtKB CARBOHYD
702	Phosphorylation	AEVPEVITSQFNNMR CCCCHHHHHHCCCEE	22.96	-
780	Phosphorylation	ECEQKIHSPSGLITS HHHHHCCCCCCCCCC	25.00	23879269
782	Phosphorylation	EQKIHSPSGLITSPN HHHCCCCCCCCCCCC	49.61	23879269
860	Phosphorylation	IPDPLVATGNKMFVR CCCCEEECCCCEEEE	33.53	-
895	Phosphorylation	GGRLKAESKPRDLYS CCEEEECCCCCCCCC	53.47	28176443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.