RUN3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUN3A_HUMAN
• UniProt AC: Q59EK9
• Protein Name: RUN domain-containing protein 3A
• Gene Name: RUNDC3A
• Organism: Homo sapiens (Human).
• Sequence Length: 446
• Protein Description: May act as an effector of RAP2A in neuronal cells..
• Protein Sequence: MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEASFVQTTMA ----CCCHHHHHHHH	16.79	23607784
8	Phosphorylation	MEASFVQTTMALGLS CCCHHHHHHHHHCCC	17.15	23607784
9	Phosphorylation	EASFVQTTMALGLSS CCHHHHHHHHHCCCC	5.37	23607784
15	Phosphorylation	TTMALGLSSKKASSR HHHHHCCCCCCCCCC	38.01	23607784
16	Phosphorylation	TMALGLSSKKASSRN HHHHCCCCCCCCCCC	43.12	23607784
20	Phosphorylation	GLSSKKASSRNVAVE CCCCCCCCCCCEECH	38.42	29083192
21	Phosphorylation	LSSKKASSRNVAVER CCCCCCCCCCEECHH	32.50	29083192
215	Phosphorylation	TQSYDYLTDEEERHS CCCCCCCCCHHHHHC	34.83	27732954
222	Phosphorylation	TDEEERHSAESSTSE CCHHHHHCCCCCCCC	39.70	27732954
225	Phosphorylation	EERHSAESSTSEDNS HHHHCCCCCCCCCCC	38.34	27732954
226	Phosphorylation	ERHSAESSTSEDNSP HHHCCCCCCCCCCCC	27.71	27732954
227	Phosphorylation	RHSAESSTSEDNSPE HHCCCCCCCCCCCCC	45.47	27732954
228	Phosphorylation	HSAESSTSEDNSPEH HCCCCCCCCCCCCCC	44.92	27732954
232	Phosphorylation	SSTSEDNSPEHPYLP CCCCCCCCCCCCCCC	43.94	27732954
237	Phosphorylation	DNSPEHPYLPLVTDE CCCCCCCCCCCCCCC	23.90	27732954
248	Phosphorylation	VTDEDSWYSKWHKME CCCCCCHHHHHHHHH	12.34	-
319	Phosphorylation	LELQEQLTGLIPSDH HHHHHHHHCCCCCCC	29.63	-
324	Phosphorylation	QLTGLIPSDHAPLAQ HHHCCCCCCCCCCCC	34.73	27732954
333	Phosphorylation	HAPLAQGSKELTTPL CCCCCCCCCCCCCCC	15.75	27732954
341	Phosphorylation	KELTTPLVNQWPSLG CCCCCCCHHCCCCCC	5.43	32142685
346	Phosphorylation	PLVNQWPSLGTLNGA CCHHCCCCCCCCCCC	36.15	32142685
361	Phosphorylation	EGASNSKLYRRHSFM CCCCCCCCCCCCCCC	3.95	32142685
365	Phosphorylation	NSKLYRRHSFMSTEP CCCCCCCCCCCCCCC	19.18	32142685
366	Phosphorylation	SKLYRRHSFMSTEPL CCCCCCCCCCCCCCC	22.34	28450419
369	Phosphorylation	YRRHSFMSTEPLSAE CCCCCCCCCCCCCCH	27.84	28450419
370	Phosphorylation	RRHSFMSTEPLSAEA CCCCCCCCCCCCCHH	29.81	28450419
374	Phosphorylation	FMSTEPLSAEASLSS CCCCCCCCCHHHCCC	34.48	28450419
378	Phosphorylation	EPLSAEASLSSDSQR CCCCCHHHCCCCCCC	21.93	25921289
381	Phosphorylation	SAEASLSSDSQRLGE CCHHHCCCCCCCCCC	46.72	25921289
416	Phosphorylation	GLCGSLASIPSCKSL HHHHHHHHCCCCHHH	40.08	-
419	Phosphorylation	GSLASIPSCKSLASF HHHHHCCCCHHHHHC	32.29	28348404
422	Phosphorylation	ASIPSCKSLASFKSN HHCCCCHHHHHCCCC	33.23	28348404
425	Phosphorylation	PSCKSLASFKSNECL CCCHHHHHCCCCCEE	38.20	24719451
428	Phosphorylation	KSLASFKSNECLVSD HHHHHCCCCCEEEEC	35.53	27732954
434	Phosphorylation	KSNECLVSDSPEGSP CCCCEEEECCCCCCC	21.30	27732954
436	Phosphorylation	NECLVSDSPEGSPAL CCEEEECCCCCCCCC	19.83	27732954
440	Phosphorylation	VSDSPEGSPALSPS- EECCCCCCCCCCCC-	12.82	27732954
444	Phosphorylation	PEGSPALSPS----- CCCCCCCCCC-----	25.79	27732954
446	Phosphorylation	GSPALSPS------- CCCCCCCC-------	49.86	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUN3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUN3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUN3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFPT_HUMAN	TFPT	physical	16189514
RAP2A_HUMAN	RAP2A	physical	9523700
RM15_HUMAN	MRPL15	physical	25416956
TFPT_HUMAN	TFPT	physical	25416956
SYT17_HUMAN	SYT17	physical	25416956
MGN2_HUMAN	MAGOHB	physical	25416956
ARMC7_HUMAN	ARMC7	physical	25416956
CCNL2_HUMAN	CCNL2	physical	25416956
F161A_HUMAN	FAM161A	physical	25416956
TBRG1_HUMAN	TBRG1	physical	25416956
ZN587_HUMAN	ZNF587	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
AP1M1_HUMAN	AP1M1	physical	21516116
RUN3B_HUMAN	RUNDC3B	physical	28514442
CC186_HUMAN	CCDC186	physical	28514442
EPS15_HUMAN	EPS15	physical	28514442
AAK1_HUMAN	AAK1	physical	28514442
EPDR1_HUMAN	EPDR1	physical	28514442
RBP1_HUMAN	RALBP1	physical	28514442
EP15R_HUMAN	EPS15L1	physical	28514442
CLIP1_HUMAN	CLIP1	physical	28514442
NECP2_HUMAN	NECAP2	physical	28514442
AP2A2_HUMAN	AP2A2	physical	28514442
AP2A1_HUMAN	AP2A1	physical	28514442
REPS1_HUMAN	REPS1	physical	28514442
AP2M1_HUMAN	AP2M1	physical	28514442
ITSN1_HUMAN	ITSN1	physical	28514442
AP1B1_HUMAN	AP1B1	physical	28514442
BMP2K_HUMAN	BMP2K	physical	28514442
GEMI_HUMAN	GMNN	physical	28514442
RPA49_HUMAN	POLR1E	physical	28514442
AP2S1_HUMAN	AP2S1	physical	28514442
AP2B1_HUMAN	AP2B1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.