| UniProt ID | CLC4G_HUMAN | |
|---|---|---|
| UniProt AC | Q6UXB4 | |
| Protein Name | C-type lectin domain family 4 member G | |
| Gene Name | CLEC4G | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 293 | |
| Subcellular Localization |
Cell membrane Single-pass type II membrane protein . |
|
| Protein Description | Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.; (Microbial infection) Acts as a receptor for Japanese encephalitis virus.; (Microbial infection) Acts as a receptor for Ebolavirus.; (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV.; (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein. [PubMed: 22156524] | |
| Protein Sequence | MDTTRYSKWGGSSEEVPGGPWGRWVHWSRRPLFLALAVLVTTVLWAVILSILLSKASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQNNSCEPCPTSWLSFEGSCYFFSVPKTTWAAAQDHCADASAHLVIVGGLDEQGFLTRNTRGRGYWLGLRAVRHLGKVQGYQWVDGVSLSFSHWNQGEPNDAWGRENCVMMLHTGLWNDAPCDSEKDGWICEKRHNC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MDTTRYSKWGG ----CCCCCCCCCCC | 24.28 | 22210691 | |
| 12 | Phosphorylation | RYSKWGGSSEEVPGG CCCCCCCCCCCCCCC | 30.55 | 20166139 | |
| 13 | Phosphorylation | YSKWGGSSEEVPGGP CCCCCCCCCCCCCCC | 40.84 | 24275569 | |
| 41 | Phosphorylation | LALAVLVTTVLWAVI HHHHHHHHHHHHHHH | 13.66 | 22144111 | |
| 73 | N-linked_Glycosylation | GHDLLRTNASKQTAA HHHHHHCCHHHHHHH | 35.46 | UniProtKB CARBOHYD | |
| 159 | N-linked_Glycosylation | LEAVRLQNNSCEPCP HHHHHCCCCCCCCCC | 47.15 | UniProtKB CARBOHYD | |
| 270 | Phosphorylation | NCVMMLHTGLWNDAP HEEEEEECCCCCCCC | 29.97 | 27134283 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLC4G_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLC4G_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLC4G_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| APOH_HUMAN | APOH | physical | 18624398 | |
| CAP7_HUMAN | AZU1 | physical | 18624398 | |
| EIF3I_HUMAN | EIF3I | physical | 18624398 | |
| IN35_HUMAN | IFI35 | physical | 18624398 | |
| COX1_HUMAN | COX1 | physical | 18624398 | |
| RSSA_HUMAN | RPSA | physical | 18624398 | |
| ASGR1_HUMAN | ASGR1 | physical | 18624398 | |
| CBPN_HUMAN | CPN1 | physical | 18624398 | |
| IF6_HUMAN | EIF6 | physical | 18624398 | |
| PRDX1_HUMAN | PRDX1 | physical | 18624398 | |
| SHBG_HUMAN | SHBG | physical | 18624398 | |
| APOA1_HUMAN | APOA1 | physical | 18624398 | |
| ARSA_HUMAN | ARSA | physical | 18624398 | |
| CAN1_HUMAN | CAPN1 | physical | 18624398 | |
| FRIL_HUMAN | FTL | physical | 18624398 | |
| M3K11_HUMAN | MAP3K11 | physical | 18624398 | |
| NU214_HUMAN | NUP214 | physical | 18624398 | |
| KPYR_HUMAN | PKLR | physical | 18624398 | |
| WBP2_HUMAN | WBP2 | physical | 18624398 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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