dbPTM

CAP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CAP7_HUMAN
UniProt AC	P20160
Protein Name	Azurocidin {ECO:0000303\|PubMed:2501794}
Gene Name	AZU1 {ECO:0000312\|HGNC:HGNC:913}
Organism	Homo sapiens (Human).
Sequence Length	251
Subcellular Localization	Cytoplasmic granule membrane Peripheral membrane protein Cytoplasmic side . Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte d
Protein Description	This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G..
Protein Sequence	MTRLTVLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLDREANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQCRPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRGPDFFTRVALFRDWIDGVLNNPGPGPA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
126	N-linked_Glycosylation	LQLDREANLTSSVTI HHHHCCCCCCCCEEE	38.81	2226832
126	N-linked_Glycosylation	LQLDREANLTSSVTI HHHHCCCCCCCCEEE	38.81	17623646
140	N-linked_Glycosylation	ILPLPLQNATVEAGT EEEECCCCCEECCCC	45.31	2226832
140	N-linked_Glycosylation	ILPLPLQNATVEAGT EEEECCCCCEECCCC	45.31	17623646
171	N-linked_Glycosylation	SRFPRFVNVTVTPED CCCCCEEEEEECCHH	22.49	2226832
171	N-linked_Glycosylation	SRFPRFVNVTVTPED CCCCCEEEEEECCHH	22.49	17623646

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CAP7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CAP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CAP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZY11B_HUMAN	ZYG11B	physical	26186194
SH3G2_HUMAN	SH3GL2	physical	26186194
SH3G1_HUMAN	SH3GL1	physical	26186194
ERBIN_HUMAN	ERBB2IP	physical	26186194
KBTB6_HUMAN	KBTBD6	physical	26186194
BIN3_HUMAN	BIN3	physical	26186194
OSBL6_HUMAN	OSBPL6	physical	26186194
STAT3_HUMAN	STAT3	physical	26186194
DIEXF_HUMAN	DIEXF	physical	26186194
FBX2_HUMAN	FBXO2	physical	26186194
ERBIN_HUMAN	ERBB2IP	physical	28514442
SH3G1_HUMAN	SH3GL1	physical	28514442
SH3G2_HUMAN	SH3GL2	physical	28514442
FIGL1_HUMAN	FIGNL1	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
FBX2_HUMAN	FBXO2	physical	28514442
BIN3_HUMAN	BIN3	physical	28514442
DIEXF_HUMAN	DIEXF	physical	28514442
OSBL6_HUMAN	OSBPL6	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CAP7_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-126; ASN-140 AND ASN-171,AND MASS SPECTROMETRY.	19159218 [Abstract]
"Amino acid sequence of CAP37, a human neutrophil granule-derivedantibacterial and monocyte-specific chemotactic glycoproteinstructurally similar to neutrophil elastase."; Pohl J., Pereira H.A., Martin N.M., Spitznagel J.K.; FEBS Lett. 272:200-204(1990). Cited for: PROTEIN SEQUENCE OF 27-248.	2226832 [Abstract]