IN35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IN35_HUMAN
• UniProt AC: P80217
• Protein Name: Interferon-induced 35 kDa protein
• Gene Name: IFI35
• Organism: Homo sapiens (Human).
• Sequence Length: 286
• Subcellular Localization: Nucleus. Nuclear following IFN treatment.
• Protein Description: Not yet known..
• Protein Sequence: MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQMSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNIPDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAPLDAAL ------CCHHHHHHH	38.30	30108239
36	Phosphorylation	LRKELGDSPKDKVPF HHHHHCCCCCCCCCC	31.86	21815630
40	Ubiquitination	LGDSPKDKVPFSVPK HCCCCCCCCCCCCCC	58.91	21906983
40 (in isoform 2)	Ubiquitination	-	58.91	21906983
40 (in isoform 1)	Ubiquitination	-	58.91	21906983
44	Phosphorylation	PKDKVPFSVPKIPLV CCCCCCCCCCCCCEE	31.29	23403867
64	Ubiquitination	QQDPEVPKSLVSNLR CCCCCCCHHHHHHCE	62.69	29967540
122	Phosphorylation	PLELPMVTTIQMSSQ CCCCCCEEEEEECCC	16.36	22210691
123	Phosphorylation	LELPMVTTIQMSSQL CCCCCEEEEEECCCC	9.59	22210691
133 (in isoform 2)	Phosphorylation	-	23.35	-
138	Phosphorylation	SGRRVLVTGFPASLR CCCEEEEECCCCCCC	29.01	-
143	Phosphorylation	LVTGFPASLRLSEEE EEECCCCCCCCCHHH	17.79	-
154	Ubiquitination	SEEELLDKLEIFFGK CHHHHHHHHHHHHCC	48.25	21906983
154 (in isoform 1)	Ubiquitination	-	48.25	21906983
156	Ubiquitination	EELLDKLEIFFGKTR HHHHHHHHHHHCCCC	43.41	-
156 (in isoform 2)	Ubiquitination	-	43.41	21906983
161 (in isoform 1)	Ubiquitination	-	38.87	21906983
161	Ubiquitination	KLEIFFGKTRNGGGD HHHHHHCCCCCCCCC	38.87	2190698
163	Ubiquitination	EIFFGKTRNGGGDVD HHHHCCCCCCCCCCC	43.19	-
163 (in isoform 2)	Ubiquitination	-	43.19	21906983
178	Phosphorylation	VRELLPGSVMLGFAR HHHHCCCCEEEEECC	11.47	-
221	Ubiquitination	YVNGEIQKAEIRSQP CCCCEEEEEEHHCCC	54.36	-
223	Ubiquitination	NGEIQKAEIRSQPVP CCEEEEEEHHCCCCC	46.07	-
223 (in isoform 2)	Ubiquitination	-	46.07	-
259	Ubiquitination	EIHFQKPTRGGGEVE EEEEECCCCCCCEEE	49.32	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IN35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IN35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IN35_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NMI_HUMAN	NMI	physical	10950963
KDM1A_HUMAN	KDM1A	physical	23455924
RO52_HUMAN	TRIM21	physical	26342464
NMI_HUMAN	NMI	physical	26342464

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.