SDK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDK1_HUMAN
• UniProt AC: Q7Z5N4
• Protein Name: Protein sidekick-1 {ECO:0000303|PubMed:15213259}
• Gene Name: SDK1 {ECO:0000303|PubMed:15213259, ECO:0000312|HGNC:HGNC:19307}
• Organism: Homo sapiens (Human).
• Sequence Length: 2213
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse .
• Protein Description: Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions..
• Protein Sequence: MARGARPSAAGGGGGGAEPPERAGPGRPRGSPPGRARPSLAPRPGPEPSRPRAAPETSGGDTAGAGRCGGRRAAKLGPGRRGWWALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTPLTGFSSFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	PPGRARPSLAPRPGP CCCCCCCCCCCCCCC	31.45	24719451
108	Phosphorylation	DVAPYFKTEPGLPQI CCHHHCCCCCCCCEE	37.20	-
154	Phosphorylation	TYSSEYKYIIPSLQK CCCCEECEECCCHHH	11.81	-
158	Phosphorylation	EYKYIIPSLQKLDAG EECEECCCHHHHCCC	32.78	-
167	Phosphorylation	QKLDAGFYRCVVRNR HHHCCCHHHHHHHCC	11.37	-
189	Phosphorylation	KSEVQVAYMGSFMDT CCCCCEEEEECCCCC	11.80	18083107
192	Phosphorylation	VQVAYMGSFMDTDQR CCEEEEECCCCCCCC	10.81	24719451
196	Phosphorylation	YMGSFMDTDQRKTVS EEECCCCCCCCCCHH	23.42	24719451
216	Phosphorylation	ILNLLPITSYPRPQV HHHCCCCCCCCCCCE	21.92	22210691
217	Phosphorylation	LNLLPITSYPRPQVT HHCCCCCCCCCCCEE	33.58	24719451
271	N-linked_Glycosylation	VNEKNGENKTSPFIH EECCCCCCCCCCCEE	55.06	UniProtKB CARBOHYD
273	Phosphorylation	EKNGENKTSPFIHLS CCCCCCCCCCCEEEE	53.89	24719451
301	N-linked_Glycosylation	TIVVPPGNRSVVAGS EEEECCCCCCEECCC	38.54	UniProtKB CARBOHYD
435	Phosphorylation	SRLQNPRYKVLASGG HHCCCCCEEEEEECC	13.50	24719451
440	Phosphorylation	PRYKVLASGGLRIQK CCEEEEEECCCEEEE	29.27	24719451
550	N-linked_Glycosylation	VFIQDAGNYTCYAAN EEEEECCCEEEEEEC	30.57	UniProtKB CARBOHYD
563	N-linked_Glycosylation	ANTEGSLNASATLTV ECCCCCCCEEEEEEE	33.28	UniProtKB CARBOHYD
572	Phosphorylation	SATLTVWNRTSIVHP EEEEEEEECCCCCCC	32.77	32142685
572	N-linked_Glycosylation	SATLTVWNRTSIVHP EEEEEEEECCCCCCC	32.77	UniProtKB CARBOHYD
584	Phosphorylation	VHPPEDHVVIKGTTA CCCCCCCEEEECCEE	8.02	32142685
602	Phosphorylation	CGATHDPRVSLRYVW CCCCCCCCEEEEEEE	36.39	32142685
604	Ubiquitination	ATHDPRVSLRYVWKK CCCCCCEEEEEEEEE	14.38	32142685
617	Phosphorylation	KKDNVALTPSSTSRI EECCEEECCCCCCEE	16.04	-
619	Phosphorylation	DNVALTPSSTSRIVV CCEEECCCCCCEEEE	40.80	-
620	Phosphorylation	NVALTPSSTSRIVVE CEEECCCCCCEEEEE	31.44	-
621	Phosphorylation	VALTPSSTSRIVVEK EEECCCCCCEEEEEE	26.77	-
642	Phosphorylation	SQTWSGDIGDYSCEI EEECCCCCCCEEEEE	5.29	32142685
655	N-linked_Glycosylation	EIVSEGGNDSRMARL EEEECCCCCCCEEEE	55.74	UniProtKB CARBOHYD
679	N-linked_Glycosylation	QNLLVSPNSSHSHAV CCEEECCCCCCCCEE	48.95	UniProtKB CARBOHYD
719	Phosphorylation	SPWKVHLSNVGPEMT CCCEEEEECCCCCCC	18.00	29449344
726	Phosphorylation	SNVGPEMTGVTVSGL ECCCCCCCCEEECCC	27.17	29449344
729	Phosphorylation	GPEMTGVTVSGLTPA CCCCCCEEECCCCCC	15.42	29449344
731	Phosphorylation	EMTGVTVSGLTPART CCCCEEECCCCCCCE	20.79	29449344
734	Phosphorylation	GVTVSGLTPARTYQF CEEECCCCCCCEEEE	20.59	29449344
782	N-linked_Glycosylation	IVASGRTNQSIMVQW EEECCCCCCCEEEEE	32.04	UniProtKB CARBOHYD
821	N-linked_Glycosylation	PGEYQQRNITSPEVN CCCHHHCCCCCCCCC	37.24	UniProtKB CARBOHYD
882	N-linked_Glycosylation	NVQTEAVNSTTIQFL CCCEECCCCCEEEEC	40.46	UniProtKB CARBOHYD
1015	N-linked_Glycosylation	SWEVYGRNDSRLTHT EEEEECCCCCCCEEE	47.44	UniProtKB CARBOHYD
1024	N-linked_Glycosylation	SRLTHTLNSTTHEYK CCCEEEECCCCCEEE	38.17	UniProtKB CARBOHYD
1181	Phosphorylation	DVAPTSVTVRTASET CCCCCEEEEEECCCC	12.20	24719451
1230	Phosphorylation	SAVAQVVSDRLEREF HHHHHHHHHHHHCEE	20.39	27050516
1282	N-linked_Glycosylation	VPSAAPENVSAEAVS CCCCCCCCCCCCCCC	31.80	UniProtKB CARBOHYD
1333	N-linked_Glycosylation	RSHIVRGNHTQSALL CCHHCCCCHHHHHHH	25.19	UniProtKB CARBOHYD
1494	Phosphorylation	QAEVTARSLRLQWVP HHHHEECEEEEEECC	18.51	22210691
1618	Phosphorylation	LQGYRIYYRELEYEA CCCEEEEEEEEEEEC	8.67	27273156
1654	N-linked_Glycosylation	QSSFKTVNSSSTSTM CCCCCCCCCCCCCCC	41.21	UniProtKB CARBOHYD
1670	Phosphorylation	ELTHLKKYRRYEVIM HHHHHHHHCCCEEEE	9.95	-
1673	Phosphorylation	HLKKYRRYEVIMTAY HHHHHCCCEEEEEEE	12.92	-
1678	Phosphorylation	RRYEVIMTAYNIIGE CCCEEEEEEEHHHCC	18.18	-
1748	N-linked_Glycosylation	YWEADSQNETEKMKV EEECCCCCCCEEEEE	63.21	UniProtKB CARBOHYD
1767	N-linked_Glycosylation	EPVVRLKNLTSHTKY CCEEEEECCCCCCEE	53.82	UniProtKB CARBOHYD
1774	Phosphorylation	NLTSHTKYLVSISAF CCCCCCEEEEEEEEE	17.31	22210691
1777	Phosphorylation	SHTKYLVSISAFNAA CCCEEEEEEEEECCC	14.29	22210691
1779	Phosphorylation	TKYLVSISAFNAAGD CEEEEEEEEECCCCC	21.21	22210691
1819	N-linked_Glycosylation	EITSTTLNVSWGEPA ECCEEEEEECCCCCC	24.55	UniProtKB CARBOHYD
1893	N-linked_Glycosylation	YGPELQANITAGPAE ECCCEEEEEEECCCC	21.12	UniProtKB CARBOHYD
1905	Phosphorylation	PAEGSPGSPRDVLVT CCCCCCCCCCCEEEE	21.83	26091039
2083	Phosphorylation	TFSKKNGTRSPPRPS CCCCCCCCCCCCCCC	37.05	27174698
2085	Phosphorylation	SKKNGTRSPPRPSPG CCCCCCCCCCCCCCC	38.81	20363803
2090	Phosphorylation	TRSPPRPSPGGLHYS CCCCCCCCCCCCCCC	37.14	27732954
2096	Phosphorylation	PSPGGLHYSDEDICN CCCCCCCCCCHHHHH	23.90	26657352
2097	Phosphorylation	SPGGLHYSDEDICNK CCCCCCCCCHHHHHH	24.63	20363803
2113	Phosphorylation	NGAVLTESVSLKEKS CCEEEEECEECCCCC	16.27	25849741
2115	Phosphorylation	AVLTESVSLKEKSAD EEEEECEECCCCCCC	42.90	19664994
2117	Ubiquitination	LTESVSLKEKSADAS EEECEECCCCCCCCC	56.44	32142685
2120	Phosphorylation	SVSLKEKSADASESE CEECCCCCCCCCCCC	32.26	27732954
2124	Phosphorylation	KEKSADASESEATDS CCCCCCCCCCCCCCC	42.05	27732954
2126	Phosphorylation	KSADASESEATDSDY CCCCCCCCCCCCCCH	30.00	22210691
2129	Phosphorylation	DASESEATDSDYEDA CCCCCCCCCCCHHHH	31.80	27732954
2131	Phosphorylation	SESEATDSDYEDALP CCCCCCCCCHHHHCC	37.42	27732954
2133	Phosphorylation	SEATDSDYEDALPKH CCCCCCCHHHHCCCC	21.47	27732954
2151	Phosphorylation	NHYMSDPTYYNSWKR CCCCCCCHHHHHHHH	43.56	27732954
2152	Phosphorylation	HYMSDPTYYNSWKRR CCCCCCHHHHHHHHH	13.16	27732954
2153	Phosphorylation	YMSDPTYYNSWKRRA CCCCCHHHHHHHHHH	12.75	27732954
2155	Phosphorylation	SDPTYYNSWKRRAQG CCCHHHHHHHHHHCC	20.18	27732954
2170	Phosphorylation	RAPAPHRYEAVAGSE CCCCCCCEEECCCCC	12.76	27642862
2195	Phosphorylation	TQSAGGVYTPAGPGA ECCCCCEECCCCCCC	15.41	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDK1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SDK1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.