HEG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEG1_HUMAN
• UniProt AC: Q9ULI3
• Protein Name: Protein HEG homolog 1
• Gene Name: HEG1
• Organism: Homo sapiens (Human).
• Sequence Length: 1381
• Subcellular Localization: Isoform 1: Cell membrane ; Single-pass type I membrane protein . Cell junction.; Isoform 2: Secreted .
• Protein Description: Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions..
• Protein Sequence: MASPRASRWPPPLLLLLLPLLLLPPAAPGTRDPPPSPARRALSLAPLAGAGLELQLERRPEREPPPTPPRERRGPATPGPSYRAPEPGAATQRGPSGRAPRGGSADAAWKHWPESNTEAHVENITFYQNQEDFSTVSSKEGVMVQTSGKSHAASDAPENLTLLAETADARGRSGSSSRTNFTILPVGYSLEIATALTSQSGNLASESLHLPSSSSEFDERIAAFQTKSGTASEMGTERAMGLSEEWTVHSQEATTSAWSPSFLPALEMGELTTPSRKRNSSGPDLSWLHFYRTAASSPLLDLSSSSESTEKLNNSTGLQSSSVSQTKTMHVATVFTDGGPRTLRSLTVSLGPVSKTEGFPKDSRIATTSSSVLLSPSAVESRRNSRVTGNPGDEEFIEPSTENEFGLTSLRWQNDSPTFGEHQLASSSEVQNGSPMSQTETVSRSVAPMRGGEITAHWLLTNSTTSADVTGSSASYPEGVNASVLTQFSDSTVQSGGSHTALGDRSYSESSSTSSSESLNSSAPRGERSIAGISYGQVRGTAIEQRTSSDHTDHTYLSSTFTKGERALLSITDNSSSSDIVESSTSYIKISNSSHSEYSSFFHAQTERSNISSYDGEYAQPSTESPVLHTSNLPSYTPTINMPNTSVVLDTDAEFVSDSSSSSSSSSSSSSSGPPLPLPSVSQSHHLFSSILPSTRASVHLLKSTSDASTPWSSSPSPLPVSLTTSTSAPLSVSQTTLPQSSSTPVLPRARETPVTSFQTSTMTSFMTMLHSSQTADLKSQSTPHQEKVITESKSPSLVSLPTESTKAVTTNSPLPPSLTESSTEQTLPATSTNLAQMSPTFTTTILKTSQPLMTTPGTLSSTASLVTGPIAVQTTAGKQLSLTHPEILVPQISTEGGISTERNRVIVDATTGLIPLTSVPTSAKEMTTKLGVTAEYSPASRSLGTSPSPQTTVVSTAEDLAPKSATFAVQSSTQSPTTVSSSASVNSCAVNPCLHNGECVADNTSRGYHCRCPPSWQGDDCSVDVNECLSNPCPSTAMCNNTQGSFICKCPVGYQLEKGICNLVRTFVTEFKLKRTFLNTTVEKHSDLQEVENEITKTLNMCFSALPSYIRSTVHASRESNAVVISLQTTFSLASNVTLFDLADRMQKCVNSCKSSAEVCQLLGSQRRIFRAGSLCKRKSPECDKDTSICTDLDGVALCQCKSGYFQFNKMDHSCRACEDGYRLENETCMSCPFGLGGLNCGNPYQLITVVIAAAGGGLLLILGIALIVTCCRKNKNDISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGSTKNLLQMTDVYYSPTSVRNPELERNGLYPAYTGLPGSRHSCIFPGQYNPSFISDESRRRDYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	O-linked_Glycosylation	SPARRALSLAPLAGA CHHHHHHHHHHHCCC	22.85	OGP
67	O-linked_Glycosylation	PEREPPPTPPRERRG CCCCCCCCCCHHHCC	52.26	22171320
67	Phosphorylation	PEREPPPTPPRERRG CCCCCCCCCCHHHCC	52.26	-
77	O-linked_Glycosylation	RERRGPATPGPSYRA HHHCCCCCCCCCCCC	31.73	55825983
81	O-linked_Glycosylation	GPATPGPSYRAPEPG CCCCCCCCCCCCCCC	32.92	55825987
91	O-linked_Glycosylation	APEPGAATQRGPSGR CCCCCCCCCCCCCCC	20.47	55835923
96	O-linked_Glycosylation	AATQRGPSGRAPRGG CCCCCCCCCCCCCCC	43.67	55835929
123	N-linked_Glycosylation	NTEAHVENITFYQNQ CCCEEEEEEEEEECH	37.20	UniProtKB CARBOHYD
138	Phosphorylation	EDFSTVSSKEGVMVQ HHCCCCCCCCCEEEE	30.32	29759185
146	O-linked_Glycosylation	KEGVMVQTSGKSHAA CCCEEEEECCCCCCC	28.21	55833561
147	O-linked_Glycosylation	EGVMVQTSGKSHAAS CCEEEEECCCCCCCC	27.42	55833565
150	O-linked_Glycosylation	MVQTSGKSHAASDAP EEEECCCCCCCCCCC	23.14	55832489
154	O-linked_Glycosylation	SGKSHAASDAPENLT CCCCCCCCCCCCCHH	34.78	OGP
159	N-linked_Glycosylation	AASDAPENLTLLAET CCCCCCCCHHEEEEC	36.95	16335952
161	O-linked_Glycosylation	SDAPENLTLLAETAD CCCCCCHHEEEECCC	31.16	OGP
179	Phosphorylation	RSGSSSRTNFTILPV CCCCCCCCCEEEECC	36.31	-
180	N-linked_Glycosylation	SGSSSRTNFTILPVG CCCCCCCCEEEECCC	30.84	UniProtKB CARBOHYD
182	Phosphorylation	SSSRTNFTILPVGYS CCCCCCEEEECCCEE	24.55	-
198	O-linked_Glycosylation	EIATALTSQSGNLAS HHHHHHHCCCCCCCC	24.17	OGP
205	O-linked_Glycosylation	SQSGNLASESLHLPS CCCCCCCCCCCCCCC	30.77	OGP
205	Phosphorylation	SQSGNLASESLHLPS CCCCCCCCCCCCCCC	30.77	29759185
212	Phosphorylation	SESLHLPSSSSEFDE CCCCCCCCCCCHHHH	49.57	29759185
213	Phosphorylation	ESLHLPSSSSEFDER CCCCCCCCCCHHHHH	35.62	29759185
214	Phosphorylation	SLHLPSSSSEFDERI CCCCCCCCCHHHHHH	37.92	29759185
215	Phosphorylation	LHLPSSSSEFDERIA CCCCCCCCHHHHHHH	44.20	27130503
226	O-linked_Glycosylation	ERIAAFQTKSGTASE HHHHHHHCCCCCHHH	22.26	55830955
230	Phosphorylation	AFQTKSGTASEMGTE HHHCCCCCHHHHHHH	33.82	29759185
236	Phosphorylation	GTASEMGTERAMGLS CCHHHHHHHHHCCCC	22.46	-
243	Phosphorylation	TERAMGLSEEWTVHS HHHHCCCCCCEEECC	27.95	29759185
250	Phosphorylation	SEEWTVHSQEATTSA CCCEEECCCCCCCCC	25.94	29759185
259	O-linked_Glycosylation	EATTSAWSPSFLPAL CCCCCCCCCHHHHHH	15.47	OGP
261	O-linked_Glycosylation	TTSAWSPSFLPALEM CCCCCCCHHHHHHHH	33.62	OGP
303	Phosphorylation	SSPLLDLSSSSESTE CCCCCCCCCCCHHHH	28.04	22199227
304	Phosphorylation	SPLLDLSSSSESTEK CCCCCCCCCCHHHHH	45.22	22199227
305	Phosphorylation	PLLDLSSSSESTEKL CCCCCCCCCHHHHHH	34.45	22199227
306	Phosphorylation	LLDLSSSSESTEKLN CCCCCCCCHHHHHHH	37.20	22199227
308	Phosphorylation	DLSSSSESTEKLNNS CCCCCCHHHHHHHCC	43.76	22199227
309	Phosphorylation	LSSSSESTEKLNNST CCCCCHHHHHHHCCC	32.84	22199227
314	N-linked_Glycosylation	ESTEKLNNSTGLQSS HHHHHHHCCCCCCCC	51.92	UniProtKB CARBOHYD
328	O-linked_Glycosylation	SSVSQTKTMHVATVF CCCCCCCEEEEEEEE	18.85	55828199
333	O-linked_Glycosylation	TKTMHVATVFTDGGP CCEEEEEEEECCCCC	18.31	55828205
336	O-linked_Glycosylation	MHVATVFTDGGPRTL EEEEEEECCCCCCEE	29.42	55828209
345	O-linked_Glycosylation	GGPRTLRSLTVSLGP CCCCEEEEEEEEECC	31.35	55828819
345	Phosphorylation	GGPRTLRSLTVSLGP CCCCEEEEEEEEECC	31.35	28787133
347	O-linked_Glycosylation	PRTLRSLTVSLGPVS CCEEEEEEEEECCCC	14.86	55828825
349	O-linked_Glycosylation	TLRSLTVSLGPVSKT EEEEEEEEECCCCCC	23.52	55828829
349	Phosphorylation	TLRSLTVSLGPVSKT EEEEEEEEECCCCCC	23.52	28787133
354	O-linked_Glycosylation	TVSLGPVSKTEGFPK EEEECCCCCCCCCCC	36.67	55828833
354	Phosphorylation	TVSLGPVSKTEGFPK EEEECCCCCCCCCCC	36.67	-
356	O-linked_Glycosylation	SLGPVSKTEGFPKDS EECCCCCCCCCCCCC	33.56	46225313
356	Phosphorylation	SLGPVSKTEGFPKDS EECCCCCCCCCCCCC	33.56	-
363	O-linked_Glycosylation	TEGFPKDSRIATTSS CCCCCCCCCEEECCC	31.54	55832793
363	Phosphorylation	TEGFPKDSRIATTSS CCCCCCCCCEEECCC	31.54	-
367	O-linked_Glycosylation	PKDSRIATTSSSVLL CCCCCEEECCCCEEE	25.49	55831511
367	Phosphorylation	PKDSRIATTSSSVLL CCCCCEEECCCCEEE	25.49	27273156
368	O-linked_Glycosylation	KDSRIATTSSSVLLS CCCCEEECCCCEEEC	20.00	55831515
368	Phosphorylation	KDSRIATTSSSVLLS CCCCEEECCCCEEEC	20.00	27273156
369	O-linked_Glycosylation	DSRIATTSSSVLLSP CCCEEECCCCEEECH	19.09	55831519
375	O-linked_Glycosylation	TSSSVLLSPSAVESR CCCCEEECHHHHHHH	16.79	55831523
377	O-linked_Glycosylation	SSVLLSPSAVESRRN CCEEECHHHHHHHHC	41.38	55831527
381	O-linked_Glycosylation	LSPSAVESRRNSRVT ECHHHHHHHHCCCCC	29.91	OGP
381	Phosphorylation	LSPSAVESRRNSRVT ECHHHHHHHHCCCCC	29.91	27273156
388	O-linked_Glycosylation	SRRNSRVTGNPGDEE HHHCCCCCCCCCCCC	30.08	OGP
400	O-linked_Glycosylation	DEEFIEPSTENEFGL CCCCCCCCCCCCCCC	35.25	OGP
400	Phosphorylation	DEEFIEPSTENEFGL CCCCCCCCCCCCCCC	35.25	29759185
401	O-linked_Glycosylation	EEFIEPSTENEFGLT CCCCCCCCCCCCCCC	54.25	OGP
401	Phosphorylation	EEFIEPSTENEFGLT CCCCCCCCCCCCCCC	54.25	29759185
428	Phosphorylation	EHQLASSSEVQNGSP CCCCCCCCCCCCCCC	39.01	29759185
462	N-linked_Glycosylation	TAHWLLTNSTTSADV EEEEEECCCCCCCCC	37.01	UniProtKB CARBOHYD
492	O-linked_Glycosylation	LTQFSDSTVQSGGSH EEECCCCCCCCCCCC	27.79	OGP
506	Phosphorylation	HTALGDRSYSESSST CCCCCCCCCCCCCCC	37.44	-
507	Phosphorylation	TALGDRSYSESSSTS CCCCCCCCCCCCCCC	19.83	-
508	Phosphorylation	ALGDRSYSESSSTSS CCCCCCCCCCCCCCC	32.05	27251275
510	Phosphorylation	GDRSYSESSSTSSSE CCCCCCCCCCCCCCC	24.53	29759185
512	Phosphorylation	RSYSESSSTSSSESL CCCCCCCCCCCCCHH	41.40	27251275
513	O-linked_Glycosylation	SYSESSSTSSSESLN CCCCCCCCCCCCHHC	34.28	OGP
513	Phosphorylation	SYSESSSTSSSESLN CCCCCCCCCCCCHHC	34.28	27251275
514	Phosphorylation	YSESSSTSSSESLNS CCCCCCCCCCCHHCC	33.54	29759185
515	Phosphorylation	SESSSTSSSESLNSS CCCCCCCCCCHHCCC	37.91	24505115
516	Phosphorylation	ESSSTSSSESLNSSA CCCCCCCCCHHCCCC	30.85	27251275
520	N-linked_Glycosylation	TSSSESLNSSAPRGE CCCCCHHCCCCCCCC	43.10	16335952
522	O-linked_Glycosylation	SSESLNSSAPRGERS CCCHHCCCCCCCCCC	41.02	OGP
522	Phosphorylation	SSESLNSSAPRGERS CCCHHCCCCCCCCCC	41.02	29759185
529	O-linked_Glycosylation	SAPRGERSIAGISYG CCCCCCCCCCCEEEE	16.70	55825671
529	Phosphorylation	SAPRGERSIAGISYG CCCCCCCCCCCEEEE	16.70	-
534	O-linked_Glycosylation	ERSIAGISYGQVRGT CCCCCCEEEEEEECC	23.46	55825675
547	O-linked_Glycosylation	GTAIEQRTSSDHTDH CCEEEEECCCCCCCC	32.07	55824093
548	O-linked_Glycosylation	TAIEQRTSSDHTDHT CEEEEECCCCCCCCE	35.64	55824099
549	O-linked_Glycosylation	AIEQRTSSDHTDHTY EEEEECCCCCCCCEE	32.57	55824105
552	O-linked_Glycosylation	QRTSSDHTDHTYLSS EECCCCCCCCEEEEC	34.17	55824111
555	O-linked_Glycosylation	SSDHTDHTYLSSTFT CCCCCCCEEEECCCC	29.03	55824117
558	O-linked_Glycosylation	HTDHTYLSSTFTKGE CCCCEEEECCCCCCC	19.54	55824121
559	O-linked_Glycosylation	TDHTYLSSTFTKGER CCCEEEECCCCCCCE	25.58	55824125
560	O-linked_Glycosylation	DHTYLSSTFTKGERA CCEEEECCCCCCCEE	31.76	55824131
562	O-linked_Glycosylation	TYLSSTFTKGERALL EEEECCCCCCCEEEE	37.92	55824137
572	Phosphorylation	ERALLSITDNSSSSD CEEEEEEECCCCCCC	26.25	30576142
576	Phosphorylation	LSITDNSSSSDIVES EEEECCCCCCCCEEC	39.87	30576142
610	N-linked_Glycosylation	HAQTERSNISSYDGE ECCCCCCCCCCCCCC	44.37	UniProtKB CARBOHYD
661	Phosphorylation	EFVSDSSSSSSSSSS EEECCCCCCCCCCCC	37.89	-
662	Phosphorylation	FVSDSSSSSSSSSSS EECCCCCCCCCCCCC	35.87	-
663	Phosphorylation	VSDSSSSSSSSSSSS ECCCCCCCCCCCCCC	35.87	-
664	Phosphorylation	SDSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
665	Phosphorylation	DSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
666	Phosphorylation	SSSSSSSSSSSSSSG CCCCCCCCCCCCCCC	35.87	-
670	Phosphorylation	SSSSSSSSSSGPPLP CCCCCCCCCCCCCCC	30.39	25332170
672	Phosphorylation	SSSSSSSSGPPLPLP CCCCCCCCCCCCCCC	58.21	25332170
680	O-linked_Glycosylation	GPPLPLPSVSQSHHL CCCCCCCCCCCCHHH	41.92	OGP
680	Phosphorylation	GPPLPLPSVSQSHHL CCCCCCCCCCCCHHH	41.92	25332170
684	Phosphorylation	PLPSVSQSHHLFSSI CCCCCCCCHHHHHHH	12.84	25332170
689	O-linked_Glycosylation	SQSHHLFSSILPSTR CCCHHHHHHHCCCCH	23.87	55823619
690	O-linked_Glycosylation	QSHHLFSSILPSTRA CCHHHHHHHCCCCHH	22.32	55823625
694	O-linked_Glycosylation	LFSSILPSTRASVHL HHHHHCCCCHHHEEE	27.38	55823631
694	Phosphorylation	LFSSILPSTRASVHL HHHHHCCCCHHHEEE	27.38	25332170
695	O-linked_Glycosylation	FSSILPSTRASVHLL HHHHCCCCHHHEEEE	28.45	55823637
715	O-linked_Glycosylation	ASTPWSSSPSPLPVS CCCCCCCCCCCCCEE	24.71	OGP
791	Phosphorylation	PHQEKVITESKSPSL CCCCEEECCCCCCCC	36.87	25247763
793	Phosphorylation	QEKVITESKSPSLVS CCEEECCCCCCCCEE	29.77	25247763
803	O-linked_Glycosylation	PSLVSLPTESTKAVT CCCEECCCCCCCCEE	48.11	55835423
818	Phosphorylation	TNSPLPPSLTESSTE CCCCCCCCCCCCCCC	46.08	-
875	Phosphorylation	TGPIAVQTTAGKQLS CCCEEEEECCCCCCC	16.41	-
876	Phosphorylation	GPIAVQTTAGKQLSL CCEEEEECCCCCCCC	19.13	-
911	Phosphorylation	NRVIVDATTGLIPLT CEEEEECCCCCEECC	19.55	-
922	Phosphorylation	IPLTSVPTSAKEMTT EECCCCCCCHHHHHH	38.88	-
934	O-linked_Glycosylation	MTTKLGVTAEYSPAS HHHHCCCCEEECCCH	16.39	55833683
938	O-linked_Glycosylation	LGVTAEYSPASRSLG CCCCEEECCCHHCCC	12.90	55833687
941	O-linked_Glycosylation	TAEYSPASRSLGTSP CEEECCCHHCCCCCC	26.28	55833693
952	O-linked_Glycosylation	GTSPSPQTTVVSTAE CCCCCCCCEEEECHH	25.58	OGP
956	O-linked_Glycosylation	SPQTTVVSTAEDLAP CCCCEEEECHHHHCC	19.98	OGP
1077	Phosphorylation	TEFKLKRTFLNTTVE HHHHHHHHHCCCCCC	30.77	29396449
1081	Phosphorylation	LKRTFLNTTVEKHSD HHHHHCCCCCCCCCC	34.07	29396449
1082	Phosphorylation	KRTFLNTTVEKHSDL HHHHCCCCCCCCCCH	26.12	23532336
1137	N-linked_Glycosylation	TTFSLASNVTLFDLA EEEECHHCEEHHHHH	25.78	UniProtKB CARBOHYD
1287	Phosphorylation	ISKLIFKSGDFQMSP HHHHHCCCCCCCCCC	32.61	23186163
1293	Phosphorylation	KSGDFQMSPYAEYPK CCCCCCCCCCCCCCC	12.18	25159151
1295	Phosphorylation	GDFQMSPYAEYPKNP CCCCCCCCCCCCCCC	12.54	29396449
1298	Phosphorylation	QMSPYAEYPKNPRSQ CCCCCCCCCCCCCCC	16.01	25884760
1300	Ubiquitination	SPYAEYPKNPRSQEW CCCCCCCCCCCCCHH	77.88	23000965
1319	Phosphorylation	IEMHENGSTKNLLQM HHHHHCCCCCCHHHC	48.03	30266825
1320	Phosphorylation	EMHENGSTKNLLQMT HHHHCCCCCCHHHCC	25.91	30266825
1327	Phosphorylation	TKNLLQMTDVYYSPT CCCHHHCCEEECCCC	14.89	22199227
1330	Phosphorylation	LLQMTDVYYSPTSVR HHHCCEEECCCCCCC	10.88	22199227
1331	Phosphorylation	LQMTDVYYSPTSVRN HHCCEEECCCCCCCC	14.18	25106551
1332	Phosphorylation	QMTDVYYSPTSVRNP HCCEEECCCCCCCCH	12.19	21815630
1334	Phosphorylation	TDVYYSPTSVRNPEL CEEECCCCCCCCHHH	33.63	26356563
1335	Phosphorylation	DVYYSPTSVRNPELE EEECCCCCCCCHHHH	23.59	26356563
1347	Phosphorylation	ELERNGLYPAYTGLP HHHHCCCCCCCCCCC	6.29	21945579
1350	Phosphorylation	RNGLYPAYTGLPGSR HCCCCCCCCCCCCCC	9.24	21945579
1351	Phosphorylation	NGLYPAYTGLPGSRH CCCCCCCCCCCCCCC	34.06	21945579
1356	Phosphorylation	AYTGLPGSRHSCIFP CCCCCCCCCCCCCCC	25.53	21945579
1359	Phosphorylation	GLPGSRHSCIFPGQY CCCCCCCCCCCCCCC	14.06	29255136
1366	Phosphorylation	SCIFPGQYNPSFISD CCCCCCCCCHHHCCC	34.65	27642862
1380	Phosphorylation	DESRRRDYF------ CHHHCCCCC------	14.91	-
1400	Ubiquitination	-------------------------- --------------------------		23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEG1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HEG1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-159 AND ASN-520, AND MASSSPECTROMETRY.
PubMed: 16335952

O-linked Glycosylation

"Human urinary glycoproteomics; attachment site specific analysis ofN-and O-linked glycosylations by CID and ECD.";
Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.;
Mol. Cell. Proteomics 0:0-0(2011).
Cited for: GLYCOSYLATION AT THR-67, STRUCTURE OF CARBOHYDRATES, AND MASSSPECTROMETRY.
PubMed: 22171320