SPTN5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPTN5_HUMAN
• UniProt AC: Q9NRC6
• Protein Name: Spectrin beta chain, non-erythrocytic 5
• Gene Name: SPTBN5
• Organism: Homo sapiens (Human).
• Sequence Length: 3674
• Subcellular Localization: Cytoplasm, cytoskeleton. Detected prominently in the outer segments of photoreceptor rods and cones and in the basolateral membrane and cytosol of gastric epithelial cells.
• Protein Sequence: MAGQPHSPRELLGAAGHRSRRPSTELRVPPSPSLTMDSQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVHFLENSSRALAFLRAKVPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQGLGAQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGRQPSSSSWDSCRGNLQGSSLSLFLDERMAAEKVASIALLDLTGARCERLRGRHGRKHTFSLRLTSGAEILFAAPSEEQAESWWRALGSTAAQSLSPKLKAKPVSSLNECTTKDARPGCLLRSDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
178	Phosphorylation	GASAALLSTKEALLV CCCHHHHHCHHHHHH	37.98	24719451
191	Phosphorylation	LVWCQRKTASYTNVN HHHHCCCCCCCCCCC	24.03	28270605
193	Phosphorylation	WCQRKTASYTNVNIT HHCCCCCCCCCCCCH	37.41	28270605
194	Phosphorylation	CQRKTASYTNVNITD HCCCCCCCCCCCCHH	10.40	28270605
195	Phosphorylation	QRKTASYTNVNITDF CCCCCCCCCCCCHHC	30.14	28270605
200	Phosphorylation	SYTNVNITDFSRSWS CCCCCCCHHCCHHHC	26.28	28270605
203	Phosphorylation	NVNITDFSRSWSDGL CCCCHHCCHHHCCCC	28.37	28270605
277	Phosphorylation	IMTYVSLYYHYCSRL HHHHHHHHHHHHHHH	4.82	-
280	Phosphorylation	YVSLYYHYCSRLHQG HHHHHHHHHHHHCCC	3.97	22210691
282	Phosphorylation	SLYYHYCSRLHQGQT HHHHHHHHHHCCCHH	30.61	22210691
353	Phosphorylation	AAFTIFRTQEKPPRL HHHHHHCCCCCCCHH	30.26	20058876
440	Phosphorylation	HKAALRESFLKDAEQ HHHHHHHHHHHHHHH	29.46	24719451
766	Phosphorylation	SWLRERRSSLERASC HHHHHHHHHHHHHCC	45.56	28152594
767	Phosphorylation	WLRERRSSLERASCG HHHHHHHHHHHHCCC	32.22	28152594
916	Phosphorylation	QLWLEKQTVLLQRVQ HHHHHHHHHHHHHHC	24.96	-
936	Phosphorylation	LEVMQLKYENFLTAL CHHHHHHHHHHHHHH	25.38	-
969	Phosphorylation	QRYPGNSTQIQRQQE HHCCCCHHHHHHHHH	33.42	22817900
1277	Phosphorylation	HGEKLVQSQHPAAHT HHHHHHHCCCCCHHH	23.99	-
1284	Phosphorylation	SQHPAAHTVREQLQS CCCCCHHHHHHHHHH	19.28	-
1297	Phosphorylation	QSIQAQWTRLQGRSE HHHHHHHHHHCCCHH	14.93	-
1313	Phosphorylation	RRRQLLASLQLQEWK HHHHHHHHHHHHHHH	19.33	24043423
1346	Phosphorylation	HEPSGARRNILQTLK CCCCHHHHHHHHHHH	33.72	24719451
1381	Phosphorylation	QVGRELLSRRPCGQE HHHHHHHHCCCCCHH	38.58	24719451
1399	Phosphorylation	TRLQGLRSKWEALNR HHHHHHHHHHHHHHH	47.35	28270605
1444	Phosphorylation	QLEGALQSSETGQDL HHHHHHHCCHHHHHH	30.87	-
1445	Phosphorylation	LEGALQSSETGQDLR HHHHHHCCHHHHHHH	26.64	-
1447	Phosphorylation	GALQSSETGQDLRSS HHHHCCHHHHHHHHH	41.93	-
1480	Phosphorylation	AKMAALASMAHGMAA HHHHHHHHHHHHHHC	19.83	-
1488	Phosphorylation	MAHGMAASPAILEET HHHHHHCCHHHHHHH	12.82	-
1650	Phosphorylation	EEKRPLVSSRDYGRD HCCCCCCCCCCCCCC	27.60	24719451
1651	Phosphorylation	EKRPLVSSRDYGRDE CCCCCCCCCCCCCCH	22.99	-
1686	Phosphorylation	WSSMEELDQTAQTLT HHCHHHHHHHHHHHC	47.25	24719451
1694	Phosphorylation	QTAQTLTGPEVPEQQ HHHHHHCCCCCCHHH	21.34	24719451
1721	Phosphorylation	ALQELAATRDRELEG HHHHHHHCCCHHHHH	27.74	24719451
1729	Phosphorylation	RDRELEGTLRLHEFL CCHHHHHHHHHHHHH	10.18	24719451
2035	Phosphorylation	QDQRDQVYQTWARKQ HHHHHHHHHHHHHHH	8.45	29978859
2037	Phosphorylation	QRDQVYQTWARKQER HHHHHHHHHHHHHHH	11.91	29978859
2321	Phosphorylation	IRSISDLSLQLKNRD HHHHHHHHHHHCCCC	21.04	25247763
2398	Phosphorylation	DCGKDLESVQRLLRK HCCCCHHHHHHHHHH	30.74	26029660
2434	Phosphorylation	VGRLCQRSPEAAHGL HHHHHHHCHHHHHHC	10.95	22617229
2619	Acetylation	EPLLWKHKMLEWDLE CCHHHHCCCCCEEEE	41.26	7431283
2633	Phosphorylation	EVQAGKISALEATAR EECCCCHHHHHHHHH	30.22	29496963
2733	Phosphorylation	FQAELDASMHQQQEL HHHHHCHHHHHHHHH	19.23	27050516
2755	Phosphorylation	LQGGHPASEAIQERL HCCCCCHHHHHHHHH	31.82	-
2791	Methylation	QKACEALRLRRSMEE HHHHHHHHHHHHHHH	32.95	12020299
2842	Phosphorylation	AVDKKARQAEALLGQ HHHHHHHHHHHHHHH	48.71	24719451
2877	Phosphorylation	RLLQRFKSLREPLQE HHHHHHHHHHHHHHH	29.91	24719451
3052	Phosphorylation	KRDLEAFSPRIERLQ HHHHHHHHHHHHHHH	21.95	24719451
3073	Phosphorylation	ESRKNPESPKVLAQL HHCCCCCCHHHHHHH	31.14	24275569
3180	Phosphorylation	ERGAPRRYPHIQAQR HCCCCCCCCCHHHHH	10.63	-
3245	Phosphorylation	EDGGHSLSSVRTLQQ CCCCCCHHHHHHHHH	29.78	24719451
3554	Phosphorylation	LPGGRQPSSSSWDSC CCCCCCCCCCCHHHC	34.22	24043423
3555	Phosphorylation	PGGRQPSSSSWDSCR CCCCCCCCCCHHHCC	34.77	24043423
3556	Phosphorylation	GGRQPSSSSWDSCRG CCCCCCCCCHHHCCC	39.52	24043423
3557	Phosphorylation	GRQPSSSSWDSCRGN CCCCCCCCHHHCCCC	36.53	24043423
3560	Phosphorylation	PSSSSWDSCRGNLQG CCCCCHHHCCCCCCC	10.23	24043423
3568	Phosphorylation	CRGNLQGSSLSLFLD CCCCCCCCHHHHHHC	18.36	30377224
3569	Phosphorylation	RGNLQGSSLSLFLDE CCCCCCCHHHHHHCH	28.89	30377224
3571	Phosphorylation	NLQGSSLSLFLDERM CCCCCHHHHHHCHHH	21.01	30377224
3608	Phosphorylation	GRHGRKHTFSLRLTS CCCCCCCEEEEEECC	20.25	23403867
3626	Phosphorylation	ILFAAPSEEQAESWW EEEECCCHHHHHHHH	53.74	24719451
3643	Phosphorylation	LGSTAAQSLSPKLKA HCHHHHHHCCHHHCC	26.53	24719451
3645	Phosphorylation	STAAQSLSPKLKAKP HHHHHHCCHHHCCCC	25.82	24719451
3661	Phosphorylation	SSLNECTTKDARPGC CCCCCCCCCCCCCCC	38.29	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPTN5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPTN5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPTN5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPTN5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.