KCD18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCD18_HUMAN
• UniProt AC: Q6PI47
• Protein Name: BTB/POZ domain-containing protein KCTD18
• Gene Name: KCTD18
• Organism: Homo sapiens (Human).
• Sequence Length: 426
• Protein Sequence: MEGHKAEEEVLDVLRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRDGRLFKYLLDYLHGEVQIPTDEQTRIALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYATKTDGTDAIEKQLGGRIHSKGIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLLGSLRHMAPIRKRRLITFNEADESVNYKTGPKPVRFLGPSTSTQIKVKNSASVTVSPASAIQTSAGATANRFQSGSRRKAAQRSAPSRATALVGTGAPGHPQASPGAASAENGGTHLPPAKVLLSDKKPTPQRVIKLKRTPLCATAPCLPSPTATRQANSLKPLPGEAARALGVRTENGKNKGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	SLCRFKDSMLASMFS HHHHCHHHHHHHHHC	19.11	24719451
43	Phosphorylation	SMLASMFSGRFPLKT HHHHHHHCCCCCCCC	22.03	28674151
115	Phosphorylation	ANEMETYSLRSNIEL HHHHHHCHHHHCHHH	25.40	24719451
147	Phosphorylation	PTVWVLHYLNTSGAS CEEEEEEEECCCCCC	9.48	-
150	Phosphorylation	WVLHYLNTSGASCES EEEEEECCCCCCCCC	26.41	-
151	Phosphorylation	VLHYLNTSGASCESR EEEEECCCCCCCCCE	31.15	-
158 (in isoform 3)	Ubiquitination	-	11.40	21890473
165	Phosphorylation	RIIGVYATKTDGTDA EEEEEEEEECCCCHH	19.45	27251275
175	Ubiquitination	DGTDAIEKQLGGRIH CCCHHHHHHHCCCCC	44.72	-
223	Phosphorylation	AWEGKGVSYWRVPHE HHCCCCCCCCCCCHH	27.87	-
224	Phosphorylation	WEGKGVSYWRVPHEL HCCCCCCCCCCCHHH	8.53	-
245	Phosphorylation	EERPLLGSLRHMAPI CCCCCCCCCCCCCCC	23.38	24719451
259	Phosphorylation	IRKRRLITFNEADES CCCCEEEEECCCCCC	25.62	27282143
284	Phosphorylation	RFLGPSTSTQIKVKN EEECCCCCCEEEEEC	23.74	28555341
294	Phosphorylation	IKVKNSASVTVSPAS EEEECCCCEEECHHH	20.38	29214152
296	Phosphorylation	VKNSASVTVSPASAI EECCCCEEECHHHHH	16.87	25627689
298	Phosphorylation	NSASVTVSPASAIQT CCCCEEECHHHHHHC	12.84	27050516
301	Phosphorylation	SVTVSPASAIQTSAG CEEECHHHHHHCCCC	29.32	29214152
337	Phosphorylation	RATALVGTGAPGHPQ CCCEEEECCCCCCCC	23.77	27251275
346	Phosphorylation	APGHPQASPGAASAE CCCCCCCCCCCCCCC	20.72	27251275
351	Phosphorylation	QASPGAASAENGGTH CCCCCCCCCCCCCCC	35.27	27251275
363	Ubiquitination	GTHLPPAKVLLSDKK CCCCCCHHEECCCCC	38.91	21890473
363 (in isoform 1)	Ubiquitination	-	38.91	21890473
367	Phosphorylation	PPAKVLLSDKKPTPQ CCHHEECCCCCCCCC	43.13	25159151
370	Ubiquitination	KVLLSDKKPTPQRVI HEECCCCCCCCCCEE	60.14	-
372	Phosphorylation	LLSDKKPTPQRVIKL ECCCCCCCCCCEEEC	40.72	26055452
387	Phosphorylation	KRTPLCATAPCLPSP CCCCCCCCCCCCCCC	30.09	27732954
393	Phosphorylation	ATAPCLPSPTATRQA CCCCCCCCCCHHCCC	23.18	25849741
395	Phosphorylation	APCLPSPTATRQANS CCCCCCCCHHCCCCC	45.02	27732954
397	Phosphorylation	CLPSPTATRQANSLK CCCCCCHHCCCCCCC	26.28	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCD18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCD18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCD18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.